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CD163

  • Official Full Name

    CD163 Molecule

  • Overview

    CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
  • Synonyms

    M130; MM130; scavenger receptor cysteine-rich type 1 protein M130; OTTHUMP00000238617; OTTHUMP00000238618; CD163 Molecule; OTTHUMP00000238619; OTTHUMP00000238620; hemoglobin scavenger receptor; macrophage-associated antigen; CD163;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chromatography Reagents
  • Human
  • Mouse
  • Pig
  • Pig (Su+H70:H146s scrofa)
  • Rat
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • Human cells
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Avi
  • Myc
  • DDK
  • DYKDDDDK
  • Flag
  • GST
  • His (Fc)
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD163-112H Active Recombinant Human CD163, His-tagged Mammalian cells His
Human CD163-510H Active Recombinant Human CD163, His-tagged Mammalian cells His
Human CD163-4272H Recombinant Human CD163, His-tagged E.coli His
Human CD163-27220TH Recombinant Human CD163 Wheat Germ N/A 91 amino acids
Human CD163-0726H Recombinant Human CD163 Protein, GST-Tagged Wheat Germ GST
Human CD163-10910H Recombinant Human CD163, GST-tagged E.coli GST 46-401a.a.
Human CD163-7683HCL Recombinant Human CD163 293 Cell Lysate HEK293 N/A
Human CD163-151H Recombinant Human CD163 Protein, DYKDDDDK-tagged Human cells DYKDDDDK
Human CD163-064H Recombinant Human CD163 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CD163-356H Recombinant Human CD163 protein, His-tagged HEK293 His 1004
Human CD163-034H Recombinant Human CD163 Protein, Ser42-Ser1045, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Ser42-Ser1045
Human CD163-654H Recombinant Human CD163 Protein, His-tagged E.coli N-His Leu719-Thr1029
Human CD163-1405H Recombinant Human CD163 Protein (Gly46-Gly401), N-His tagged E.coli N-His Gly46-Gly401
Human CD163-2625H Recombinant Human CD163 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD163-182H Recombinant Human CD163 Protein, C-His-tagged E.coli C-His
Human CD163-2625H-B Recombinant Human CD163 Protein Pre-coupled Magnetic Beads HEK293
Human CD163-5932M CD163 protein-coupled magnetic MicroBeads
Human CD163-1463HFL Recombinant Full Length Human CD163 Protein, C-Flag-tagged Mammalian cells Flag
Human CD163-5324H Recombinant Human CD163 Protein (Thr41-Ser1045), C-His tagged Mammalian cells C-His Thr41-Ser1045
Human CD163-125H Recombinant Human CD163 Protein, His-tagged HEK293 His 1156
Mouse Cd163-371M Active Recombinant Mouse Cd163, His-tagged Mammalian cells His
Mouse Cd163-1849M Recombinant Mouse Cd163 protein, His-tagged E.coli His Pro697~Gly972
Mouse Cd163-1436M-B Recombinant Mouse Cd163 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cd163-1436M Recombinant Mouse Cd163 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CD163-1022M Recombinant Mouse CD163 Protein (86-365 aa), His-tagged E.coli His 86-365 aa
Mouse CD163-1667M Recombinant Mouse CD163 Protein (86-365 aa), His-tagged Yeast His 86-365 aa
Rat Cd163-1850R Recombinant Rat Cd163 protein, His & T7-tagged E.coli His/T7 Pro693~Asp939 (Accession # D3Z9U2)
Pig (Su+H70:H146s scrofa) CD163-0009P Recombinant Pig CD163 Protein (Pro477-Ser577), C-His-tagged Baculovirus-Insect cells C-His Pro477-Ser577
Pig CD163-94P Recombinant Porcine CD163 E.coli N/A
Pig CD163-0008P Recombinant Pig CD163 Protein (Pro447-Ser577), C-His-tagged Baculovirus-Insect cells C-His Pro447-Ser577
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD163 involved in several pathways and played different roles in them. We selected most pathways CD163 participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD163 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Binding and Uptake of Ligands by Scavenger ReceptorsHSPH1;CD163;COL3A1;IGKV1-5;HPX;APOA1B;Alb;SCGB3A2;COL1A1
Scavenging of heme from plasmaHP;CD163;AMBP;LOC479668;HPX;NFX1
Vesicle-mediated transportCOPE;CLVS1;GJB7;PICALMB;GJB3;NECAP1;DTNBP1B;SH3D19;TRAPPC5

CD163 has several biochemical functions, for example, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD163 itself. We selected most functions CD163 had, and list some proteins which have the same functions with CD163. You can find most of the proteins on our site.

Function Related Protein
protein bindingMGST1;BRAT1;PPP1R8;DNAJC15;MYO9B;FCER2;NUDT16L1;VLDLR;HIST1H1E
scavenger receptor activityCD163;POLR1B;VTN;LOXL3B;TMPRSS4A;TMPRSS13B;ENPP1;PGBD1;VTNB

CD163 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD163 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD163.

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Research Area

Related articles

Ong, CB; Brandenberger, C; et al. Immunohistochemical Characterization and Morphometric Analysis of Macrophages in Rat Mammary Tumors. VETERINARY PATHOLOGY 52:414-418(2015).
Theate, I; van Baren, N; et al. Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues. CANCER IMMUNOLOGY RESEARCH 3:161-172(2015).
  • Q&As
  • Reviews

Q&As (5)

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How does CD163 contribute to the understanding of cardiovascular diseases? 03/17/2021

CD163 is implicated in the development and progression of cardiovascular diseases, serving as a marker for inflammation in atherosclerosis.

In what ways does CD163 contribute to the understanding of cancer progression? 07/30/2019

CD163 expression is studied in the context of cancer to evaluate its role in promoting or inhibiting tumor growth and metastasis.

How is CD163 involved in the pathogenesis of neurodegenerative diseases? 03/30/2017

CD163 is being investigated for its potential role in neurodegenerative diseases, where neuroinflammation is a key factor.

Are there diagnostic assays or imaging techniques that utilize CD163 as a molecular target? 11/10/2016

Some diagnostic assays and imaging techniques use CD163 as a molecular target to visualize and quantify inflammatory processes in vivo.

How is CD163 linked to autoimmune disorders such as lupus? 01/20/2016

CD163 expression is associated with the pathogenesis of autoimmune disorders, and its modulation is being explored for therapeutic purposes.

Customer Reviews (3)

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Reviews
01/25/2023

    The outstanding performance of CD163 protein in both ELISA and protein electron microscopy structure analysis positions it as a highly valuable asset in diverse research areas.

    09/09/2019

      Its ability to accurately detect proteins and visualize their structures offers a valuable toolkit for advancing scientific understanding and discoveries.

      01/13/2016

        Whether it is protein-protein interactions, enzymatic assays, or cellular studies, CD163 protein delivers consistent and accurate data, making it a valuable tool for researchers.

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