Recombinant Human CD163 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: CD163-064H
• Product Overview: CD163 MS Standard C13 and N15-labeled recombinant protein (NP_004235) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc&DDK
• Molecular Mass: 125.4 kDa
• AA Sequence: MSKLRMVLLEDSGSADFRRHFVNLS PFTITVVLLLSACFVTSSLGGTDKE LRLVDGENKCSGRVEVKVQEEWGTV CNNGWSMEAVSVICNQLGCPTAIKA PGWANSSAGSGRIWMDHVSCRGNES ALWDCKHDGWGKHSNCTHQQDAGVT CSDGSNLEMRLTRGGNMCSGRIEIK FQGRWGTVCDDNFNIDHASVICRQL ECGSAVSFSGSSNFGEGSGPIWFDD LICNGNESALWNCKHQGWGKHNCDH AEDAGVICSKGADLSLRLVDGVTEC SGRLEVRFQGEWGTICDDGWDSYDA AVACKQLGCPTAVTAIGRVNASKGF GHIWLDSVSCQGHEPAVWQCKHHEW GKHYCNHNEDAGVTCSDGSDLELRL RGGGSRCAGTVEVEIQRLLGKVCDR GWGLKEADVVCRQLGCGSALKTSYQ VYSKIQATNTWLFLSSCNGNETSLW DCKNWQWGGLTCDHYEEAKITCSAH REPRLVGGDIPCSGRVEVKHGDTWG SICDSDFSLEAASVLCRELQCGTVV SILGGAHFGEGNGQIWAEEFQCEGH ESHLSLCPVAPRPEGTCSHSRDVGV VCSRYTEIRLVNGKTPCEGRVELKT LGAWGSLCNSHWDIEDAHVLCQQLK CGVALSTPGGARFGKGNGQIWRHMF HCTGTEQHMGDCPVTALGASLCPSE QVASVICSGNQSQTLSSCNSSSLGP TRPTIPEESAVACIESGQLRLVNGG GRCAGRVEIYHEGSWGTICDDSWDL SDAHVVCRQLGCGEAINATGSAHFG EGTGPIWLDEMKCNGKESRIWQCHS HGWGQQNCRHKEDAGVICSEFMSLR LTSEASREACAGRLEVFYNGAWGTV GKSSMSETTVGVVCRQLGCADKGKI NPASLDKAMSIPMWVDNVQCPKGPD TLWQCPSSPWEKRLASPSEETWITC DNKIRLQEGPTSCSGRVEIWHGGSW GTVCDDSWDLDDAQVVCQQLGCGPA LKAFKEAEFGQGTGPIWLNEVKCKG NESSLWDCPARRWGHSECGHKEDAA VNCTDISVQKTPQKATTGRSSRQSS FIAVGILGVVLLAIFVALFFLTKKR RQRQRLAVSSRGENLVHQIQYREMN SCLNADDLDLMNSSENSHESADFSA AELISVSKFLPISGMEKEAILSHTE KENGNLSGPTRTRPLEQKLISEEDL AANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CD163 CD163 molecule [ Homo sapiens (human) ]
• Official Symbol: CD163
• Synonyms: CD163; CD163 molecule; M130; MM130; SCARI1; scavenger receptor cysteine-rich type 1 protein M130; hemoglobin scavenger receptor; macrophage-associated antigen
• Gene ID: 9332
• mRNA Refseq: NM_004244
• Protein Refseq: NP_004235
• MIM: 605545
• UniProt ID: Q86VB7

Reviews

01/25/2023

The outstanding performance of CD163 protein in both ELISA and protein electron microscopy structure analysis positions it as a highly valuable asset in diverse research areas.

09/09/2019

Its ability to accurately detect proteins and visualize their structures offers a valuable toolkit for advancing scientific understanding and discoveries.

01/13/2016

Whether it is protein-protein interactions, enzymatic assays, or cellular studies, CD163 protein delivers consistent and accurate data, making it a valuable tool for researchers.

Q&As

How does CD163 contribute to the understanding of cardiovascular diseases?

CD163 is implicated in the development and progression of cardiovascular diseases, serving as a marker for inflammation in atherosclerosis.

In what ways does CD163 contribute to the understanding of cancer progression?

CD163 expression is studied in the context of cancer to evaluate its role in promoting or inhibiting tumor growth and metastasis.

How is CD163 involved in the pathogenesis of neurodegenerative diseases?

CD163 is being investigated for its potential role in neurodegenerative diseases, where neuroinflammation is a key factor.

Are there diagnostic assays or imaging techniques that utilize CD163 as a molecular target?

Some diagnostic assays and imaging techniques use CD163 as a molecular target to visualize and quantify inflammatory processes in vivo.

How is CD163 linked to autoimmune disorders such as lupus?

CD163 expression is associated with the pathogenesis of autoimmune disorders, and its modulation is being explored for therapeutic purposes.