| Description : |
The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
110.4 kDa |
| Protein Length : |
1156 |
| AA Sequence : |
MSKLRMVLLEDSGSADFRRHFVNLS PFTITVVLLLSACFVTSSLGGTDKE LRLVDGENKCSGRVEVKVQEEWGTV CNNGWSMEAVSVICNQLGCPTAIKA PGWANSSAGSGRIWMDHVSCRGNES ALWDCKHDGWGKHSNCTHQQDAGVT CSDGSNLEMRLTRGGNMCSGRIEIK FQGRWGTVCDDNFNIDHASVICRQL ECGSAVSFSGSSNFGEGSGPIWFDD LICNGNESALWNCKHQGWGKHNCDH AEDAGVICSKGADLSLRLVDGVTEC SGRLEVRFQGEWGTICDDGWDSYDA AVACKQLGCPTAVTAIGRVNASKGF GHIWLDSVSCQGHEPAIWQCKHHEW GKHYCNHNEDAGVTCSDGSDLELRL RGGGSRCAGTVEVEIQRLLGKVCDR GWGLKEADVVCRQLGCGSALKTSYQ VYSKIQATNTWLFLSSCNGNETSLW DCKNWQWGGLTCDHYEEAKITCSAH REPRLVGGDIPCSGRVEVKHGDTWG SICDSDFSLEAASVLCRELQCGTVV SILGGAHFGEGNGQIWAEEFQCEGH ESHLSLCPVAPRPEGTCSHSRDVGV VCSRYTEIRLVNGKTPCEGRVELKT LGAWGSLCNSHWDIEDAHVLCQQLK CGVALSTPGGARFGKGNGQIWRHMF HCTGTEQHMGDCPVTALGASLCPSE QVASVICSGNQSQTLSSCNSSSLGP TRPTIPEESAVACIESGQLRLVNGG GRCAGRVEIYHEGSWGTICDDSWDL SDAHVVCRQLGCGEAINATGSAHFG EGTGPIWLDEMKCNGKESRIWQCHS HGWGQQNCRHKEDAGVICSEFMSLR LTSEASREACAGRLEVFYNGAWGTV GKSSMSETTVGVVCRQLGCADKGKI NPASLDKAMSIPMWVDNVQCPKGPD TLWQCPSSPWEKRLASPSEETWITC DNKIRLQEGPTSCSGRVEIWHGGSW GTVCDDSWDLDDAQVVCQQLGCGPA LKAFKEAEFGQGTGPIWLNEVKCKG NESSLWDCPARRWGHSECGHKEDAA VNCTDISVQKTPQKATTGRSSRQSS FIAVGILGVVLLAIFVALFFLTKKR RQRQRLAVSSRGENLVHQIQYREMN SCLNADDLDLMNSSENSHESADFSA AELISVSKFLPISGMEKEAILSHTE KENGNL |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
