Recombinant Full Length Human CD163 Protein, C-Flag-tagged

• Cat.No.: CD163-1463HFL
• Product Overview: Recombinant Full Length Human CD163 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 125.3 kDa
• AA Sequence: MSKLRMVLLEDSGSADFRRHFVNLS PFTITVVLLLSACFVTSSLGGTDKE LRLVDGENKCSGRVEVKVQ EEWGTVCNNGWSMEAVSVICNQLGC PTAIKAPGWANSSAGSGRIWMDHVS CRGNESALWDCKHDGWGKH SNCTHQQDAGVTCSDGSNLEMRLTR GGNMCSGRIEIKFQGRWGTVCDDNF NIDHASVICRQLECGSAVS FSGSSNFGEGSGPIWFDDLICNGNE SALWNCKHQGWGKHNCDHAEDAGVI CSKGADLSLRLVDGVTECS GRLEVRFQGEWGTICDDGWDSYDAA VACKQLGCPTAVTAIGRVNASKGFG HIWLDSVSCQGHEPAVWQC KHHEWGKHYCNHNEDAGVTCSDGSD LELRLRGGGSRCAGTVEVEIQRLLG KVCDRGWGLKEADVVCRQL GCGSALKTSYQVYSKIQATNTWLFL SSCNGNETSLWDCKNWQWGGLTCDH YEEAKITCSAHREPRLVGG DIPCSGRVEVKHGDTWGSICDSDFS LEAASVLCRELQCGTVVSILGGAHF GEGNGQIWAEEFQCEGHES HLSLCPVAPRPEGTCSHSRDVGVVC SRYTEIRLVNGKTPCEGRVELKTLG AWGSLCNSHWDIEDAHVLC QQLKCGVALSTPGGARFGKGNGQIW RHMFHCTGTEQHMGDCPVTALGASL CPSEQVASVICSGNQSQTL SSCNSSSLGPTRPTIPEESAVACIE SGQLRLVNGGGRCAGRVEIYHEGSW GTICDDSWDLSDAHVVCRQ LGCGEAINATGSAHFGEGTGPIWLD EMKCNGKESRIWQCHSHGWGQQNCR HKEDAGVICSEFMSLRLTS EASREACAGRLEVFYNGAWGTVGKS SMSETTVGVVCRQLGCADKGKINPA SLDKAMSIPMWVDNVQCPK GPDTLWQCPSSPWEKRLASPSEETW ITCDNKIRLQEGPTSCSGRVEIWHG GSWGTVCDDSWDLDDAQVV CQQLGCGPALKAFKEAEFGQGTGPI WLNEVKCKGNESSLWDCPARRWGHS ECGHKEDAAVNCTDISVQK TPQKATTGRSSRQSSFIAVGILGVV LLAIFVALFFLTKKRRQRQRLAVSS RGENLVHQIQYREMNSCLN
  ADDLDLMNSSENSHESADFSAAELI SVSKFLPISGMEKEAILSHTEKENG NLSGPTRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane

Gene Information

• Gene Name: CD163 CD163 molecule [ Homo sapiens (human) ]
• Official Symbol: CD163
• Synonyms: M130; MM130; SCARI1
• Gene ID: 9332
• mRNA Refseq: NM_004244.6
• Protein Refseq: NP_004235.4
• MIM: 605545
• UniProt ID: Q86VB7