| Description : |
CD163 is a transmembrane scavenger receptor expressed on the macrophage surface. It has 9 B-type SRCR extracellular domains mediating serum haptoglobin clearing/endocytosis, pathogen binding and signal transduction, and calcium binding. CD163 is used as a surface marker of M2 type macrophages, including M2 type tumor associated macrophages (TAMs), which facilitate cancer progression by secreting cytokines to promote angiogenesis, immunosuppression and metastasis. Inflammatory stimulation and stress signal can induce extracellular domain shedding of CD163 to generate soluble CD163 (sCD163). The increased sCD163 level in serum is associated with low-grade inflammation in disease conditions. |
| Source : |
E. coli |
| Species : |
Human |
| Tag : |
C-His |
| Molecular Mass : |
~89 kDa |
| AA Sequence : |
SSLGGTDKELRLVDGENKCSGRVEV KVQEEWGTVCNNGWSMEAVSVICNQ LGCPTAIKAPGWANSSAGSGRIWMD HVSCRGNESALWDCKHDGWGKHSNC THQQDAGVTCSDGSNLEMRLTRGGN MCSGRIEIKFQGRWGTVCDDNFNID HASVICRQLECGSAVSFSGSSNFGE GSGPIWFDDLICNGNESALWNCKHQ GWGKHNCDHAEDAGVICSKGADLSL RLVDGVTECSGRLEVRFQGEWGTIC DDGWDSYDAAVACKQLGCPTAVTAI GRVNASKGFGHIWLDSVSCQGHEPA IWQCKHHEWGKHYCNHNEDAGVTCS DGSDLELRLRGGGSRCAGTVEVEIQ RLLGKVCDRGWGLKEADVVCRQLGC GSALKTSYQVYSKIQATNTWLFLSS CNGNETSLWDCKNWQWGGLTCDHYE EAKITCSAHREPRLVGGDIPCSGRV EVKHGDTWGSICDSDFSLEAASVLC RELQCGTVVSILGGAHFGEGNGQIW AEEFQCEGHESHLSLCPVAPRPEGT CSHSRDVGVVCSRYTEIRLVNGKTP CEGRVELKTLGAWGSLCNSHWDIED AHVLCQQLKCGVALSTPGGARFGKG NGQIWRHMFHCTGTEQHMGDCPVTA LGASLCPSEQVASVICSGNQSQTLS SCNSSSLGPTRPTIPEESAVACIES GQLRLVNGGGRCAGRVEIYHEGSWG TICDDSWDLSDAHVVCRQLGCGEAI NATGSAHFGEGTGPIWLDEMKCNGK ESRIWQCHSHGWGQQNCRHKEDAGV ICSEFMSLRLTSEASREACAGRLEV FYNGAWGTV |
| Purity : |
Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE). |
| Notes : |
For research use only, not for use in diagnostic procedure. |
| Storage : |
Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles. |
| Concentration : |
≥0.5 mg/mL |
| Storage Buffer : |
PBS, 4M Urea, pH7.4 |
