Recombinant Human CD163, His-tagged
Cat.No. : | CD163-4272H |
Product Overview : | CD163 Porcine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 805 amino acids and having a molecular mass of 87kDa. The CD163 is fused to an 8 amino acid His Tag at C-terminus and purified by proprietary chromatographic techniques. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a member of the scavenger receptor cysteine-rich (SRCR) superfamily, and is exclusively expressed in monocytes and macrophages. It functions as an acute phase-regulated receptor involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, and may thereby protect tissues from free hemoglobin-mediated oxidative damage. This protein may also function as an innate immune sensor for bacteria and inducer of local inflammation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Source : | E.Coli |
Species : | Human |
Tag : | His |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. The protein was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4, containing 4M Urea. |
Molecular Mass : | 87 kDa |
AA Sequence : | MDKLRMVLHE NSGSADLKLR VVDGVTECSG RLEVKFQGEW GTICDDGWDS DDAAVACKQL GCPTAVTAIG RVNASEGTGH IWLDSVSCHG HESALWQCRH HEWGKHYCNH NEDAGVTCSD GSDLELRLKG GGSHCAGTVE VEIQKLVGKV CDRSWGLKEA DVVCRQLGCG SALKTSYQVY SKTKATNTWL FVSSCNGNET SLWDCKNWQW GGLSCDHYDE AKITCSAHRK PRLVGGDIPC SGRVEVQHGD TWGTVCDSDF SLEAASVLCR ELQCGTVVSL LGGAHFGEGS GQIWAEEFQC EGHESHLSLC PVAPRPDGTC SHSRDVGVVC SRYTQIRLVN GKTPCEGRVE LNILGSWGSL CNSHWDMEDA HVLCQQLKCG VALSIPGGAP FGKGSEQVWR HMFHCTGTEK HMGDCSVTAL GASLCSSGQV ASVICSGNQS QTLSPCNSSS SDPSSSIISE ENGVACIGSG QLRLVDGGGR CAGRVEVYHE GSWGTICDDS WDLNDAHVVC KQLSCGWAIN ATGSAHFGEG TGPIWLDEIN CNGKESHIWQ CHSHGWGRHN CRHKEDAGVI CSEFMSLRLI SENSRETCAG RLEVFYNGAW GSVGKNSMSP ATVGVVCRQL GCADRGDISP ASSDKTVSRH MWVDNVQCPK GPDTLWQCPS SPWKKRLASP SEETWITCAN KIRLQEGNTN CSGRVEIWYG GSWGTVCDDS WDLEDAQVVC RQLGCGSALE AGKEAAFGQG TGPIWLNEVK CKGNETSLWD CPARSWGHSD CGHKEDAAVT CSEIAKSRES LHATGRSHHH HHHHH. |
Purity : | Greater than 95.0% as determined by HPLC and SDS-PAGE. |
Usage : | The products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. |
Stability : | Lyophilized CD163 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD163 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
Reconstitution : | It is recommended to reconstitute the lyophilized CD163 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
Gene Name : | CD163 CD163 molecule [ Homo sapiens ] |
Official Symbol : | CD163 |
Synonyms : | CD163; CD163 molecule; M130; MM130; scavenger receptor cysteine-rich type 1 protein M130; CD163 antigen; OTTHUMP00000238617; OTTHUMP00000238618; OTTHUMP00000238619; OTTHUMP00000238620; hemoglobin scavenger receptor; macrophage-associated antigen; Scavenger receptor cysteine-rich type 1 protein M130; Hemoglobin scavenger receptor |
Gene ID : | 9332 |
mRNA Refseq : | NM_004244 |
Protein Refseq : | NP_004235 |
MIM : | 605545 |
UniProt ID : | Q86VB7 |
Chromosome Location : | 12p13.3 |
Pathway : | Binding and Uptake of Ligands by Scavenger Receptors; Scavenging of heme from plasma |
Function : | protein binding; scavenger receptor activity |
Products Types
◆ Recombinant Protein | ||
Cd163-1436M | Recombinant Mouse Cd163 Protein, His (Fc)-Avi-tagged | +Inquiry |
CD163-125H | Recombinant Human CD163 Protein, His-tagged | +Inquiry |
CD163-0726H | Recombinant Human CD163 Protein, GST-Tagged | +Inquiry |
CD163-654H | Recombinant Human CD163 Protein, His-tagged | +Inquiry |
CD163-1667M | Recombinant Mouse CD163 Protein (86-365 aa), His-tagged | +Inquiry |
◆ Lysates | ||
CD163-7683HCL | Recombinant Human CD163 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionCD163 is implicated in the development and progression of cardiovascular diseases, serving as a marker for inflammation in atherosclerosis.
CD163 expression is studied in the context of cancer to evaluate its role in promoting or inhibiting tumor growth and metastasis.
CD163 is being investigated for its potential role in neurodegenerative diseases, where neuroinflammation is a key factor.
Some diagnostic assays and imaging techniques use CD163 as a molecular target to visualize and quantify inflammatory processes in vivo.
CD163 expression is associated with the pathogenesis of autoimmune disorders, and its modulation is being explored for therapeutic purposes.
Customer Reviews (3)
Write a reviewThe outstanding performance of CD163 protein in both ELISA and protein electron microscopy structure analysis positions it as a highly valuable asset in diverse research areas.
Its ability to accurately detect proteins and visualize their structures offers a valuable toolkit for advancing scientific understanding and discoveries.
Whether it is protein-protein interactions, enzymatic assays, or cellular studies, CD163 protein delivers consistent and accurate data, making it a valuable tool for researchers.
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