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Official Full Name cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
Background The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
Synonyms CDKN2C; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); p18; INK4C; p18-INK4C; cyclin-dependent kinase 4 inhibitor C; p18-INK6; CDK6 inhibitor p18; cyclin-dependent inhibitor; cyclin-dependent kinase 6 inhibitor p18;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CDKN2C-1065H Recombinant Human CDKN2C Protein, GST-Tagged Wheat Germ GST
    Human CDKN2C-117H Recombinant Human CDKN2C protein, T7-tagged E.coli T7
    Human CDKN2C-1294H Recombinant Human CDKN2C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CDKN2C-1377H Recombinant Human Cyclin-Dependent Kinase Inhibitor 2C (p18, inhibits CDK4), His-tagged E.coli His
    Human CDKN2C-1475H Recombinant Human CDKN2C, GST-tagged E.coli GST
    Human CDKN2C-30048TH Recombinant Human CDKN2C, His-tagged E.coli His
    Human CDKN2C-30049TH Recombinant Human CDKN2C, T7 -tagged E.coli T7
    Human CDKN2C-30052TH Recombinant Human CDKN2C E.coli N/A
    Human CDKN2C-3049H Recombinant Human CDKN2C, T7-tagged E.coli T7
    Human CDKN2C-4708H Recombinant Human CDKN2C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human Cdkn2c-6983H Recombinant Human p18INK4C, GST-tagged E.coli GST
    Human CDKN2C-7612HCL Recombinant Human CDKN2C 293 Cell Lysate HEK293 N/A
    Mouse Cdkn2c-871M Recombinant Mouse Cdkn2c Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rhesus Macaque CDKN2C-796R Recombinant Rhesus monkey CDKN2C Protein, His-tagged Mammalian Cell His
    Zebrafish CDKN2C-7899Z Recombinant Zebrafish CDKN2C Mammalian Cell His

    cdkn2c involved in several pathways and played different roles in them. We selected most pathways cdkn2c participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, Cellular Senescence, which may be useful for your reference. Also, other proteins which involved in the same pathway with cdkn2c were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell Cycle GORASP2; RBL2; TBC1D8; LIN9; CSNK1E; MAD1L1; GADD45A; CEP164; RB1; BUB1
    Cellular Senescence HIST1H1C; CBX8A; RBB4L; IGFBP7; CBX8B; AGO3; LMNB1; KAT5; EED; MINK1
    Cellular responses to stress ATG7; CBX4; HSBP1A; DNAJC2; BMI1A; HTATIP; CDKN2B; NUP50; ULK1A; RNF2
    Cyclin D associated events in G1 CDKN2B; CDKN2C; CDK7; E2F4; PIANP; CKS1B; CDKN2D
    E2F transcription factor network E2F6; CEBPA; CES1; RYBP; HBP1; E2F4; YY1; TRIM28; PRMT5; CES5A

    cdkn2c has several biochemical functions, for example, cyclin-dependent protein serine/threonine kinase inhibitor activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cdkn2c itself. We selected most functions cdkn2c had, and list some proteins which have the same functions with cdkn2c. You can find most of the proteins on our site.

    Function Related Protein
    cyclin-dependent protein serine/threonine kinase inhibitor activity HEXIM2; CDKN1B; KAT2B; CDKN2A; CDKN1BB; CDKN2C; CDKN2D; CDKN1A; HEXIM1; INCA1
    protein binding ITGA4; ABLIM3; ANO6; VDAC1; CLK2; FAM76B; DNA2; BLMH; TNK1; MR1
    protein kinase binding PRKAB1; MAP3K5; CADPS; PPP1R12C; CDK5RAP3; RHOD; PPP1CB; SMAD1; CD226; TCTN2

    cdkn2c has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdkn2c here. Most of them are supplied by our site. Hope this information will be useful for your research of cdkn2c.

    CDK4; CDK6; AHCYL1

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