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Official Full Name claudin 3
Background The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Synonyms CLDN3; claudin 3; C7orf1, CPETR2; claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; HRVP1; RVP1; ventral prostate.1 like protein; CPE-R 2; CPE-receptor 2; ventral prostate.1-like protein; ventral prostate.1 protein homolog
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLDN3-11293H Recombinant Human CLDN3 protein, His-tagged E. coli His
    Human CLDN3-11295H Recombinant Human CLDN3, GST-tagged E.coli GST
    Human CLDN3-1442H Recombinant Human CLDN3 Protein, GST-tagged Wheat Germ GST
    Human CLDN3-27271TH Recombinant Human CLDN3 Wheat Germ N/A
    Human CLDN3-7463HCL Recombinant Human CLDN3 293 Cell Lysate HEK293 N/A
    Mouse Cldn3-1427M Recombinant Mouse Cldn3 protein, His-tagged E.coli His
    Rat CLDN3-1435R Recombinant Rat CLDN3 Protein Mammalian Cell His
    Rhesus Macaque CLDN3-895R Recombinant Rhesus monkey CLDN3 Protein, His-tagged Mammalian Cell His
    Chicken CLDN3-5776C Recombinant Chicken CLDN3 Mammalian Cell His

    cldn3 involved in several pathways and played different roles in them. We selected most pathways cldn3 participated on our site, such as Cell adhesion molecules (CAMs), Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with cldn3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) HLA-DMA; CLDN3; CADM3; ITGB1B.2; ITGB7; PVR; CLDN8; F11R; SELPLG; CLDN18
    Cell junction organization LIMS1; CDH11; FERMT2; CDH10A; CDH9; CDH18; ANG; CADM2B; CDH4; CDH10
    Cell-Cell communication DCC; CLDN7; FBLIM1; PVRL2L; CDH10A; F11R.2; CD151; CLDN3; CDH11; KIRREL2
    Cell-cell junction organization CTNND1; PVRL2L; CADM2B; JUP; CLDN16; CADM2A; CDH18A; CDH7; CDH9; INADL
    Leukocyte transendothelial migration CLDN20; NCF2; NOX1; ITGAL; RASSF5; JAM2; RAC1; RAP1A; MMP9; NCF4
    Tight junction PRKCG; AKT2; CLDNJ; MYL2B; PPP2R1B; MYH1A; CLDN11; MYL10; CLDN15LB; F11R.1
    Tight junction interactions CLDN23; CLDN7; CLDN3; CLDN16; CLDN4; CLDN20; INADL

    cldn3 has several biochemical functions, for example, identical protein binding, structural molecule activity, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cldn3 itself. We selected most functions cldn3 had, and list some proteins which have the same functions with cldn3. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding KRTAP10-5; HOOK1; ITGB3; SDCBP; VWA1; CCDC91; MBIP; CCL3; EDC3; KDM6A
    structural molecule activity TUBA1A; MAP7D1B; CLDN11A; COL18A1; LMNB2; TUBG2; FGG; SPRR1A; GNL1; CKI
    transmembrane signaling receptor activity GP6; LILRA1; Cd79a, Cd79b; OR2A4; GHRHRL; NFAM1; TLR2-1; VIPR1B; BCAM; IL1R1

    cldn3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cldn3 here. Most of them are supplied by our site. Hope this information will be useful for your research of cldn3.

    Ricardo, S; Gerhard, R; et al. Claudin expression in breast cancer: High or low, what to expect?. HISTOLOGY AND HISTOPATHOLOGY 27:1283-1295(2012).
    Meng, J; Greenlee, AR; et al. Sertoli Cell-Specific Deletion of the Androgen Receptor Compromises Testicular Immune Privilege in Mice. BIOLOGY OF REPRODUCTION 85:254-260(2011).

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