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Recombinant Human CLDN3 Protein, GST-tagged

Cat.No. : CLDN3-1442H
Product Overview : Human CLDN3 full-length ORF ( AAH16056, 1 a.a. - 220 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 49.94 kDa
AA Sequence : MSMGLEITGTALAVLGWLGTIVCCA LPMWRVSAFIGSNIITSQNIWEGLW MNCVVQSTGQMQCKVYDSLLALPQD LQAARALIVVAILLAAFGLLVALVG AQCTNCVQDDTAKAKITIVAGVLFL LAALLTLVPVSWSANTIIRDFYNPV VPEAQKREMGAGLYVGWAAAALQLL GGALLCCSCPPREKKYTATKVVYSA PRSTGPGASLGTGYDRKDYV
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CLDN3 claudin 3 [ Homo sapiens ]
Official Symbol : CLDN3
Synonyms : CLDN3; claudin 3; C7orf1, CPETR2; claudin-3; Clostridium perfringens enterotoxin receptor 2; CPE R2; CPE receptor 2; HRVP1; RVP1; ventral prostate.1 like protein; CPE-R 2; CPE-receptor 2; ventral prostate.1-like protein; ventral prostate.1 protein homolog; C7orf1; CPE-R2; CPETR2;
Gene ID : 1365
mRNA Refseq : NM_001306
Protein Refseq : NP_001297
MIM : 602910
UniProt ID : O15551

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Is CLDN3 a potential target for drug delivery to specific tissues? 05/06/2021

Researchers are exploring the use of CLDN3 as a target for drug delivery systems, aiming to enhance the specificity of drug delivery to tissues expressing high levels of CLDN3.

How does CLDN3 impact the permeability of the intestinal epithelium? 01/15/2021

CLDN3 is involved in the tight junctions of intestinal epithelial cells, influencing the permeability of the intestinal barrier and playing a role in conditions like IBD.

In which other diseases or conditions is CLDN3 being investigated? 04/16/2019

CLDN3 is under investigation in various conditions, including infectious diseases, where its role in tight junctions may have implications for host-pathogen interactions.

Can CLDN3 be involved in inflammatory bowel diseases (IBD)? 02/02/2018

Yes, CLDN3 is implicated in the pathogenesis of inflammatory bowel diseases, and its expression levels are being studied as potential markers for disease severity.

How is CLDN3 linked to neurodegenerative diseases? 10/26/2016

Altered expression of CLDN3 in the blood-brain barrier is associated with certain neurodegenerative diseases, making it a subject of interest for researchers studying these conditions.

Customer Reviews (3)

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Reviews
04/24/2019

    The manufacturer's deep understanding of the protein and its applications enables them to promptly and effectively address any issues that may arise during my trials.

    06/30/2018

      It minimizes the risk of protein degradation and maximizes the effectiveness of the protein in various applications, such as cell signaling pathways or metabolic studies.

      12/12/2017

        This stability is particularly advantageous for long-term studies or experiments involving extended incubation periods.

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