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CLIC2

  • Official Full Name

    chloride intracellular channel 2

  • Overview

    Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 2 is a member of the p64 family; the protein is detected in fetal liver and adult skeletal muscle tissue.This gene maps to the candidate region on chromosome X for incontinentia pigmenti.
  • Synonyms

    CLIC2; chloride intracellular channel 2; chloride intracellular channel protein 2; XAP121; CLIC 2b; CLIC2_HUMAN; CLIC2b; OTTHUMP00000196471; XAP 121; OTTHUMP00000024248;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Rat
  • Rattus norvegicus (Rat)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CLIC2-3512H Recombinant Human Chloride Intracellular Channel 2, His-tagged E.coli His
Human CLIC2-1478H Recombinant Human CLIC2 Protein, GST-tagged Wheat Germ GST
Human CLIC2-27817TH Recombinant Human CLIC2 N/A
Human CLIC2-27815TH Recombinant Human CLIC2, His-tagged E.coli His 247 amino acids
Human CLIC2-7447HCL Recombinant Human CLIC2 293 Cell Lysate HEK293 N/A
Human CLIC2-403HFL Active Recombinant Full Length Human CLIC2 Protein, C-Flag-tagged Mammalian cells Flag
Human CLIC2-3907H Recombinant Human CLIC2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CLIC2-616H Recombinant Human CLIC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CLIC2-2179HF Recombinant Full Length Human CLIC2 Protein, GST-tagged In Vitro Cell Free System GST 247 amino acids
Human CLIC2-616H-B Recombinant Human CLIC2 Protein Pre-coupled Magnetic Beads HEK293
Rat CLIC2-1449R Recombinant Rat CLIC2 Protein Mammalian Cell His
Rat CLIC2-1107R-B Recombinant Rat CLIC2 Protein Pre-coupled Magnetic Beads HEK293
Rat CLIC2-1107R Recombinant Rat CLIC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL35635HF Recombinant Full Length Human Chloride Intracellular Channel Protein 2(Clic2) Protein, His-Tagged E.coli expression system His Full Length (1-247)
Rattus norvegicus (Rat) RFL14454RF Recombinant Full Length Rat Chloride Intracellular Channel Protein 2(Clic2) Protein, His-Tagged E.coli expression system His Full Length (1-245)
Rhesus Macaque CLIC2-909R Recombinant Rhesus monkey CLIC2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CLIC2-734R Recombinant Rhesus Macaque CLIC2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CLIC2-734R-B Recombinant Rhesus Macaque CLIC2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CLIC2-682Z Recombinant Zebrafish CLIC2 Mammalian Cell His
Chicken CLIC2-2786C Recombinant Chicken CLIC2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CLIC2 involved in several pathways and played different roles in them. We selected most pathways CLIC2 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with CLIC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ion channel transportFXYD7;ATP7B;ANO4;CLCN6;FXYD6;ATP1A1A.3;BEST1;CLCNK;SLC9A10
Stimuli-sensing channelsUNC79;TTYH3;ANO5;SCNN1D;TSC22D3;TRPC4AP;TRPC5;ASIC1A;ANO4
Transmembrane transport of small moleculesAQP1A.2;SLC1A7B;SLC30A1B;TRPM1A;SLC30A1A;SLC35A2;SLC5A6A;SLC38A4;SLC9A9

CLIC2 has several biochemical functions, for example, chloride channel activity, glutathione peroxidase activity, NOT glutathione transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CLIC2 itself. We selected most functions CLIC2 had, and list some proteins which have the same functions with CLIC2. You can find most of the proteins on our site.

Function Related Protein
chloride channel activityCLCA4;GABRA2;SLC1A4;CLCA5;CLCN1;CLIC5A;CLCA1;CLCN5;CLCA3
glutathione peroxidase activityCLIC2;GSTK1;GRX2;GSTZ1;GPX7;PRDX6;GPX1A;GPX8;GPX2
NOT glutathione transferase activityCLIC1;CLIC2;ALOX5AP;CLIC5;CLIC3
protein bindingSMAD2;PEX3;COPE;FAM19A4;GET4;ADM;PER2;FAM120B;DNTT
voltage-gated ion channel activityCX35B;KCNV2B;KCNH5;CYBB;KCNJ1B;CLIC4;SCN4AB;TPCN1;KCNK10

CLIC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CLIC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CLIC2.

FN1

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