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Official Full Name CDC-like kinase 1
Background This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms CLK1; CDC-like kinase 1; dual specificity protein kinase CLK1; STY; CDC like kinase 1; CLK; CLK/STY; CLK1_HUMAN; OTTHUMP00000163673; OTTHUMP00000206165; OTTHUMP00000206166; CDC28/CDC2-like kinase; protein tyrosine kinase STY
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLK1-1490H Recombinant Human CLK1 Protein, GST-His-tagged Insect Cell GST/His
    Human CLK1-1491H Recombinant Human CLK1 Protein, GST-tagged Wheat Germ GST
    Human CLK1-27274TH Recombinant Human CLK1 Wheat Germ N/A
    Human CLK1-284H Recombinant Human CDC-like Kinase 1, GST-tagged, Active Sf9 Insect Cell GST
    Human CLK1-567H Recombinant Human CLK1 Mammalian Cell His
    Human CLK1-676H Recombinant Human CDC-like Kinase 1, GST-tagged E.coli GST
    Human CLK1-7441HCL Recombinant Human CLK1 293 Cell Lysate HEK293 N/A
    Mouse CLK1-3585M Recombinant Mouse CLK1 Protein Mammalian Cell His
    Rhesus Macaque CLK1-912R Recombinant Rhesus monkey CLK1 Protein, His-tagged Mammalian Cell His
    Kit-1571 CLK1 Kinase Binding Assay Kit N/A

    clk1 involved in several pathways and played different roles in them. We selected most pathways clk1 participated on our site, such as Legionellosis, mRNA processing, which may be useful for your reference. Also, other proteins which involved in the same pathway with clk1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Legionellosis IL18; NFKB1; ITGB2L; TLR2; SAR1A; TLR5; C3; ITGAM; HSPA2; HSPA1B
    mRNA processing RNASET2B; ADAM5; VPRBP; LOC100862398; ZFML; FAM120B; CLK4; CELF2; RBM4B; CELF4

    clk1 has several biochemical functions, for example, ATP binding, non-membrane spanning protein tyrosine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by clk1 itself. We selected most functions clk1 had, and list some proteins which have the same functions with clk1. You can find most of the proteins on our site.

    Function Related Protein
    non-membrane spanning protein tyrosine kinase activity LYN; CSK; WEE2; PKDCC; PTK2AB; FES; SYK; PTK2B; TNK2B; TNK1
    protein binding ADAM33; FGF10; DLL1; FOXO3B; EEF1B2; CIB2; TMEM8B; OTX1; SIAH1A; PTPN14
    protein serine/threonine kinase activity ACVR2B; VRK2; GRK7A; DCKL1B; DYRK1B; KALRN; PINK1; PAK3; MAPK8; SYK
    protein serine/threonine/tyrosine kinase activity AURKB; AURKA; DYRK3; AKT1; CLK3; TNK2; TESK2; RPS6KA2; RPS6KB1; AURKC

    clk1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with clk1 here. Most of them are supplied by our site. Hope this information will be useful for your research of clk1.

    PDE9A; KRTAP10-7; PTPN1; N/A; SRPK2; SRPK1; PSEN2; YWHAG; PRMT5; ltp_ebvg; ezrA; PIAS4; GOLM1; q8xa11_eco57; DOCK9

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