Recombinant Human CDC-like Kinase 1, GST-tagged

• Cat.No.: CLK1-676H
• Product Overview: Recombinant human CDC-Like Kinase 1 catalytic domain (aa 129-484) with GST tag was expressed inE. coli.MW = 70.1 kDa.

Specification

• Cat. No.: CLK1-676H
• Description: CLK/STY is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins involves in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK/STY, which could phosphorylates the specific SR proteins, such as ASF/SF2, may directly regulates the activity and compartmentalization of SR splicing factors.
• Source: E. coli.
• Formulation: Liquid in 50 mM Tris, pH 7.5 + 150 mM NaCl + 0.05 mM EDTA + 0.05% Triton X-100 + 2mM DTT + 50% glycerol.
• Specific Activity: 79 nmole of phosphate transferred to myelin basic protein (MBP) per minute per mg of total protein at 30°C. Activity determined at a final protein concentration of 8.33 µg/ml.
• Storage & Stability: Stable for 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: CLK1 CDC-like kinase 1 [ Homo sapiens ]
• Synonyms: CLK1; CDC-like kinase 1; CLK; STY; CLK/STY; CDC28/CDC2-like kinase; protein tyrosine kinase STY; dual specificity protein kinase CLK1; EC 2.7.12.1
• Gene ID: 1195
• mRNA Refseq: NM_001162407
• Protein Refseq: NP_001155879
• MIM: 601951
• UniProt ID: P49759
• Chromosome Location: 2q33
• Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase activity