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Recombinant Human CLK1 Protein, GST-tagged

Cat.No. : CLK1-1491H
Product Overview : Human CLK1 full-length ORF ( NP_004062.2, 1 a.a. - 484 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 83.7 kDa
AA Sequence : MRHSKRTYCPDWDDKDWDYGKWRSS SSHKRRKRSHSSAQENKRCKYNHSK MCDSHYLESRSINEKDYHSRRYIDE YRNDYTQGCEPGHRQRDHESRYQNH SSKSSGRSGRSSYKSKHRIHHSTSH RRSHGKSHRRKRTRSVEDDEEGHLI CQSGDVLSARYEIVDTLGEGAFGKV VECIDHKAGGRHVAVKIVKNVDRYC EAARSEIQVLEHLNTTDPNSTFRCV QMLEWFEHHGHICIVFELLGLSTYD FIKENGFLPFRLDHIRKMAYQICKS VNFLHSNKLTHTDLKPENILFVQSD YTEAYNPKIKRDERTLINPDIKVVD FGSATYDDEHHSTLVSTRHYRAPEV ILALGWSQPCDVWSIGCILIEYYLG FTVFPTHDSKEHLAMMERILGPLPK HMIQKTRKRKYFHHDRLDWDEHSSA GRYVSRRCKPLKEFMLSQDVEHERL FDLIQKMLEYDPAKRITLREALKHP FFDLLKKSI
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CLK1 CDC-like kinase 1 [ Homo sapiens ]
Official Symbol : CLK1
Synonyms : CLK1; CDC-like kinase 1; dual specificity protein kinase CLK1; CDC28/CDC2-like kinase; protein tyrosine kinase STY; CLK; STY; CLK/STY;
Gene ID : 1195
mRNA Refseq : NM_001162407
Protein Refseq : NP_001155879
MIM : 601951
UniProt ID : P49759

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is CLK1 expression regulated in normal physiological conditions? 10/18/2020

CLK1 expression is tightly regulated at transcriptional and post-translational levels, ensuring its proper function in normal cellular processes.

How is CLK1 activity measured in research settings? 06/09/2020

Researchers often measure CLK1 activity through in vitro kinase assays or by monitoring its phosphorylation targets in cellular or tissue samples.

Can targeting CLK1 have implications for neurodegenerative diseases? 06/09/2018

Yes, studies suggest that CLK1 inhibitors may have therapeutic potential for neurodegenerative disorders by modulating RNA splicing.

Are there any known CLK1 mutations associated with diseases? 09/16/2017

Some studies suggest that CLK1 mutations may be associated with certain diseases, but further research is needed to establish clear links.

Are there any CLK1 inhibitors under development for cancer treatment? 01/21/2016

Yes, several CLK1 inhibitors are in preclinical and clinical development as potential anticancer agents.

Customer Reviews (3)

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Reviews
01/31/2021

    The manufacturer's commitment to customer satisfaction extends beyond technical support. They offer a comprehensive range of related products and resources to aid researchers in their trials.

    01/22/2019

      From troubleshooting to optimizing experimental protocols, the manufacturer provides diligent support to ensure the success of the trial.

      09/28/2018

        The CLK1 protein offers several advantageous features that make it an ideal choice for researchers conducting trials.

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