CYCS
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Official Full Name
cytochrome c, somatic
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Overview
This gene encodes a small heme protein that functions as a central component of the electron transport chain in;mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons;from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of;apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous;processed pseudogenes of this gene are found throughout the human genome. -
Synonyms
CYCS; cytochrome c, somatic; cytochrome c; HCS; CYC; THC4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Bovine
- Chicken
- Equine
- Human
- Mouse
- Rat
- Bovine Heart
- E. coli
- E.coli
- HEK293
- HEK293T
- Horse Heart
- In Vitro Cell Free System
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|MBP
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
CYCS involved in several pathways and played different roles in them. We selected most pathways CYCS participated on our site, such as Sulfur metabolism, Metabolic pathways, p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYCS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Sulfur metabolism | SUOX;PAPSS2;MPST;cysH;BPNT1;PAPSS2A;PAPSS2B;ETHE1;CYCS |
Metabolic pathways | AGXT2L1;ACOT1;TK1;DHRS4L2;CYP17A1;HSD17B4;HPD;CCBL2;ITPA |
p signaling pathway | Casp3;CCND2;CCNE1;SHISA5;PTEN;PPM1DB;APAF1;CCNE2;RPRMA |
Apoptosis | PKP1;NFKBIAB;PRKACB;FASLG;FAS;IKBKB;CRADD;DIABLO;TNFSF10 |
Non-alcoholic fatty liver disease (NAFLD) | NDUFA12;NDUFA2;UQCRH;LEP;NDUFS2;NDUFS1;CASP7;COX4I2;Casp3 |
Alzheimers disease | ATP5O;NDUFB4;COX4I1;ATP5F1;Atp5g2;ITPR2;NDUFS3;UQCRC2;NDUFAB1 |
Parkinsons disease | SDHC;UBE2L3;DRD1A;NDUFA2;CYCS;UQCRFS1;NDUFB8;mt-Atp8;NDUFB7 |
Amyotrophic lateral sclerosis (ALS) | CAT;PPP3CB;NEFL;MAP3K5;TRP53;SOD1;Casp3;BCL2;DERL1 |
Huntingtons disease | EP300;NDUFB10;NDUFA13;POLR2F;NDUFC1;NDUFV3;POLR2K;TAF4B;REST |
Legionellosis | PYCARD;HSPA8;CASP7;IL-8;IL12B;NFKB2;HSPA6;CXCL2;SAR1A |
Toxoplasmosis | MYD88;IL10RB;GNAI2;TNFRSF1A;ITGB1;ALOX5;XIAP;STAT3;HSPA2 |
Tuberculosis | RFX5;HSPA9;STAT1;NFYB;PPP3R2;IFNA14;IL12A;PPP3CA;SRC |
Hepatitis B | MAPK8;PRKCG;RELA;TICAM2;CREB5;IFNA5;ATF4;PIK3CB;IRF7 |
Influenza A | MYD88;BLB2;IFNA21;DNAJC3;MAVS;SOCS3;MAPK11;PRSS3;MAP2K1 |
Herpes simplex infection | PPP1CB;HLA-DQA2;IKBKB;PER1A;HLA-A;OAS2;TRAF1;Fasl;TNFSF14 |
Pathways in cancer | FGFR1;RELA;FGF17;PLD1;CKS2;VEGFB;GSTP1;GLI3;AGTR1B |
Colorectal cancer | TCF7L2;BAX;APC2;MAPK10;PIK3R3;TGFB2;CCND1;APPL1;RALGDS |
Small cell lung cancer | BIRC7;NOS2;RB1;NFKB1;TRAF1;BCL2L1;LAMC2;CCNE1;PTGS2 |
Viral myocarditis | CD28;ITGB2L;ABL1;HLA-DQB1;HLA-G;CD80;HLA-E;HLA-DRB4;HLA-DMB |
CYCS has several biochemical functions, for example, electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity, heme binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYCS itself. We selected most functions CYCS had, and list some proteins which have the same functions with CYCS. You can find most of the proteins on our site.
Function | Related Protein |
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electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity | |
heme binding | NOS1;CYP2C54;CYP2K18;CYP8B1;DGCR8;CYP46A1.4;TDO2;HEBP1;CYP2J6 |
metal ion binding | ACLYA;LONRF1L;FGD4;MAZ;TOE1;DNTT;CACNA2D3;EXTL3;IDS |
protein binding | STXBP3;PLEKHF1;ZCCHC12;ADH1A;RPL22;ENSA;GDF7;EIF3E;BCL11B |
contributes_to protein serine/threonine phosphatase activity | PPP2CB;CYCS |
CYCS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYCS here. Most of them are supplied by our site. Hope this information will be useful for your research of CYCS.
APAF1; TRAF6; KRT40; CYC12; MT-CO1; GH1; EPB41; MCC; HLA-B; VHL; CASP9
- Q&As
- Reviews
Q&As (7)
Ask a questionBcl-2 family proteins regulate CYCS release, balancing pro- and anti-apoptotic signals.
In apoptosis, CYCS activates caspases after being released into the cytosol.
It transports electrons in the mitochondrial respiratory chain, aiding ATP production.
Dysregulated CYCS activity can lead to impaired cellular energy production or excessive cell death.
CYCS is crucial for electron transport in mitochondria and inducing apoptosis.
Alterations in CYCS are linked to various diseases, including neurodegenerative conditions and cancer.
Therapeutic strategies may aim to modulate CYCS activity, influencing apoptosis in diseases like cancer.
Customer Reviews (3)
Write a reviewExcellent for cell experiments.
Good concentration, easy handling.
Quick shipping, great condition.
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