ddr2
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  • Official Full Name
  • discoidin domain receptor tyrosine kinase 2
  • Background
  • Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5 UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
  • Synonyms
  • DDR2; discoidin domain receptor tyrosine kinase 2; TKT; MIG20a; NTRKR3; TYRO10; discoidin domain-containing receptor 2; tyrosylprotein kinase; hydroxyaryl-protein kinase; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; cell migration-inducing protein 20; migration-inducing gene 16 protein; receptor protein-tyrosine kinase TKT; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; discoidin domain-containing receptor tyrosine kinase 2;
Cat.#:DDR2-2049HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDR2 Protein, His-tagged
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Cat.#:DDR2-205HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDR2 Protein, MYC/DDK-tagged
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Cat.#:DDR2-2456HTag:GST/His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human DDR2 Protein, GST-His-tagged
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Cat.#:DDR2-2457HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DDR2 Protein, GST-tagged
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Cat.#:DDR2-136HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDR2, Fc tagged
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Cat.#:DDR2-137HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDR2, None tagged
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Cat.#:DDR2-28310THTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DDR2
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Cat.#:DDR2-352HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDR2, His tagged
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Cat.#:DDR2-40HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human DDR2 protein, Flag-tagged, Biotinylated
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Cat.#:DDR2-5685HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DDR2 protein, His & T7-tagged
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Cat.#:DDR2-7277HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DDR2, His & GST tagged
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Cat.#:DDR2-759HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human DDR2 Protein, DDK/His-tagged
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Cat.#:DDR2-760HTag:DDK
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human DDR2 Protein, DDK-tagged
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Cat.#:DDR2-820HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DDR2, GST-tagged
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Cat.#:Ddr2-745MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Ddr2 Protein, Fc Chimera
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Cat.#:Ddr2-773MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ddr2, His tagged
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Cat.#:Ddr2-8782RTag:Fc
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ddr2, Fc tagged
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Cat.#:Ddr2-8783RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Ddr2, His tagged
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Cat.#:DDR2-119CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DDR2, Fc tagged
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Cat.#:DDR2-120CTag:His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DDR2, His tagged
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Cat.#:DDR2-121RTag:Fc
Source (Host):HEK293Species:Rhesus macaque
Product nameRecombinant Rhesus macaque DDR2, Fc-tagged
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Cat.#:DDR2-294HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DDR2, GST-tagged, Active
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Cat.#:DDR2-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DDR2 cell lysate
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Cat.#:DDR2-1033HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human DDR2 cell lysate
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Cat.#:DDR2-2172MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse DDR2 cell lysate
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Cat.#:DDR2-1296RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat DDR2 cell lysate
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Cat.#:DDR2-1017CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus DDR2 cell lysate
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Involved Pathway

Ddr2 involved in several pathways and played different roles in them. We selected most pathways Ddr2 participated on our site, such as Endochondral Ossification, Extracellular matrix organization, Non-integrin membrane-ECM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ddr2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endochondral Ossification
CST5; SOX6; COL2A1; ADAMTS5; ADAMTS4; SERPINH1; PTHLHA; FRZB; DDR2; IFT88
Extracellular matrix organization
COL6A2; CAPNS1; CMA1; FMOD; COL28A1; CTSK; COL19A1; MMP20; COL25A1; PTPRS
Non-integrin membrane-ECM interactions
TTR; DDR1; LAMC3; DDR2; TRAPPC4; DMD

Protein Function

Ddr2 has several biochemical functions, for example, ATP binding, collagen binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ddr2 itself. We selected most functions Ddr2 had, and list some proteins which have the same functions with Ddr2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DYRK1A; FBXO18; PCCA; CHUK; RAF1B; TAE1; MAP2K2; KIF5B; BMPR1BA; TNIKA
Function collagen binding
Related Protein PODN; COMP; SMAD4; MRC2; MTAP1A; NID1; ITGA10; SPARC; PCOLCE; CCBE1
Function protein binding
Related Protein DNER; GSE1; MPDU1; SCNM1; SPACA3; USP33; KRTAP8-1; SATB1; DDOST; HHIP
Function protein tyrosine kinase collagen receptor activity
Related Protein DDR2; DDR1
Function transmembrane receptor protein tyrosine kinase activity
Related Protein CADM2B; INSRR; FLT4; INSRA; ROR1; RET; TEK; RYK; ERBB3A; FGFR1A

Interacting Protein

Ddr2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ddr2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ddr2.
COL11A2; HSP90AB1; SHC1; imatinib; N/A; SRC; CBLB; CDC37; CHORDC1; GOLT1B

Ddr2 Related Articles

Thunnissen, E; van der Oord, K; et al. Prognostic and predictive biomarkers in lung cancer. A review. VIRCHOWS ARCHIV 464:347-358(2014).
Carafoli, F; Hohenester, E; et al. Collagen recognition and transmembrane signalling by discoidin domain receptors. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1834:2187-2194(2013).