Recombinant Human DDR2 Protein, GST-tagged

• Cat.No.: DDR2-2457H
• Product Overview: Human DDR2 full-length ORF ( NP_001014796.1, 1 a.a. - 855 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 123.1 kDa
• AA Sequence: MILIPRMLLVLFLLLPILSSAKAQV NPAICRYPLGMSGGQIPDEDITASS QWSESTAAKYGRLDSEEGDGAWCPE IPVEPDDLKEFLQIDLHTLHFITLV GTQGRHAGGHGIEFAPMYKINYSRD GTRWISWRNRHGKQVLDGNSNPYDI FLKDLEPPIVARFVRFIPVTDHSMN VCMRVELYGCVWLDGLVSYNAPAGQ QFVLPGGSIIYLNDSVYDGAVGYSM TEGLGQLTDGVSGLDDFTQTHEYHV WPGYDYVGWRNESATNGYIEIMFEF DRIRNFTTMKVHCNNMFAKGVKIFK EVQCYFRSEASEWEPNAISFPLVLD DVNPSARFVTVPLHHRMASAIKCQY HFADTWMMFSEITFQSDAAMYNNSE ALPTSPMAPTTYDPMLKVDDSNTRI LIGCLVAIIFILLAIIVIILWRQFW QKMLEKASRRMLDDEMTVSLSLPSD SSMFNNNRSSSPSEQGSNSTYDRIF PLRPDYQEPSRLIRKLPEFAPGEEE SGCSGVVKPVQPSGPEGVPHYAEAD IVNLQGVTGGNTYSVPAVTMDLLSG KDVAVEEFPRKLLTFKEKLGEGQFG EVHLCEVEGMEKFKDKDFALDVSAN QPVLVAVKMLRADANKNARNDFLKE IKIMSRLKDPNIIHLLAVCITDDPL CMITEYMENGDLNQFLSRHEPPNSS SSDVRTVSYTNLKFMATQIASGMKY LSSLNFVHRDLATRNCLVGKNYTIK IADFGMSRNLYSGDYYRIQGRAVLP IRWMSWESILLGKFTTASDVWAFGV TLWETFTFCQEQPYSQLSDEQVIEN TGEFFRDQGRQTYLPQPAICPDSVY KLMLSCWRRDTKNRPSFQEIHLLLL QQGDE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DDR2 discoidin domain receptor tyrosine kinase 2 [ Homo sapiens ]
• Official Symbol: DDR2
• Synonyms: DDR2; discoidin domain receptor tyrosine kinase 2; discoidin domain receptor family, member 2 , NTRKR3, TYRO10; discoidin domain-containing receptor 2; TKT; tyrosylprotein kinase; hydroxyaryl-protein kinase; discoidin domain receptor 2; tyrosine-protein kinase TYRO10; CD167 antigen-like family member B; cell migration-inducing protein 20; migration-inducing gene 16 protein; receptor protein-tyrosine kinase TKT; discoidin domain receptor family, member 2; neurotrophic tyrosine kinase receptor related 3; neurotrophic tyrosine kinase, receptor-related 3; discoidin domain-containing receptor tyrosine kinase 2; MIG20a; NTRKR3; TYRO10
• Gene ID: 4921
• mRNA Refseq: NM_001014796
• Protein Refseq: NP_001014796
• MIM: 191311
• UniProt ID: Q16832