Efna2
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Official Full Name
ephrin-A2
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Overview
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. -
Synonyms
EFNA2; ephrin-A2; EPLG6; ELF 1; LERK6; EFNA 2; EFNA2_HUMAN; ELF1; Eph related receptor tyrosine kinase ligand 6; EPH-related receptor tyrosine kinase ligand 6; EphrinA2; HEK7 L; HEK7 ligand; HEK7-L; HEK7L; LERK-6; Ligand of eph related kinase 6; ELF-1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Fc
- GST
- His
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Efna2 involved in several pathways and played different roles in them. We selected most pathways Efna2 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efna2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | NRP2;EZRA;SEMA6D;GNAI2;ROBO2;EPHB3A;LIMK1;AGRN;SEMA4B |
| Developmental Biology | COL6A1;PCSK6;RGMB;EPHB4A;PAQR3A;KBTBD7;AP2S1;INSM1B;SEMA4D |
| EPH-Ephrin signaling | ACTR2;EPHA10;ARPC1A;ARPC3;EPHA4A;ARHGEF28;AP2B1;EFNA3B;EFNA1B |
| EPH-ephrin mediated repulsion of cells | EFNB2;EFNA1B;AP2A2;EFNB1;EFNB2A;EFNA3;EFNA4;AP2B1;EFNA2A |
| EPHA forward signaling | EFNA1;CRKL;EFNA2;EFNA3;EPHA2;EFNA5;BLK;ARHGEF15 |
| EPHA-mediated growth cone collapse | EFNA2;EPHA4A;EFNA1A;EFNA3B;EFNA1B;EFNA4;EPHA10;EPHA2;EFNA1 |
| PI3K-Akt signaling pathway | CSH1;CSH2;PIK3AP1;CDC37;EFNA4;CSF1R;PRP2;COMP;LAMC3 |
| Rap1 signaling pathway | RGS14;LOC608458;EFNA4;EFNA2;CSF1;PFN4 |
Efna2 has several biochemical functions, for example, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Efna2 itself. We selected most functions Efna2 had, and list some proteins which have the same functions with Efna2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ephrin receptor binding | PIK3CG;EFNA5B;EFNB1;EPHA4;EFNB2A;NTRK3;EFNA1B;SHC1;Anks1 |
Efna2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efna2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efna2.
Chn2; Epha1
Research Area
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