Efna2
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Official Full Name
ephrin-A2 -
Overview
This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. -
Synonyms
EFNA2;ephrin-A2;EPLG6;ELF 1;LERK6;EFNA 2;EFNA2_HUMAN;ELF1;Eph related receptor tyrosine kinase ligand 6;EPH-related receptor tyrosine kinase ligand 6;EphrinA2;HEK7 L;HEK7 ligand;HEK7-L;HEK7L;LERK-6;Ligand of eph related kinase 6;ELF-1
Recombinant Proteins
- Mouse
- Human
- Chicken
- Rat
- HEK293
- Mammalian Cells
- Wheat Germ
- Human Cells
- In Vitro Cell Free System
- E.coli
- His
- Non
- Fc
- GST
- DDK
- Myc
- Avi
Involved Pathway
Efna2 involved in several pathways and played different roles in them. We selected most pathways Efna2 participated on our site, such as Axon guidance,Developmental Biology,EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efna2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Developmental Biology | SPAG9,SREBF2,SPRED2,CLASP1,TRPC7,NRP1A,MYOG,LEFTY1,RHOC,CDON |
| EPH-Ephrin signaling | EFNA3,EFNB1,KALRNB,KALRN,EFNB3,KDR,EPHB4B,EFNA3B,EPHA10,MYL12A |
| EPHA-mediated growth cone collapse | KDR,EFNA4,EFNA1,MYL12B,EFNA1A,MYL9,EFNA3B,EFNA1B,EPHA10,EPHA2 |
| EPH-ephrin mediated repulsion of cells | EPHA10,EFNB2,EPHA2,EFNB2A,EFNA1B,EFNB3,AP2A2,EPHB4B,EPHA4A,EFNA3 |
| EPHA forward signaling | EFNA1,BLK,ARHGEF15,CRKL,EPHA2,EFNA5,EFNA3 |
| Rap1 signaling pathway | PFN4,RGS14,LOC608458,EFNA4,CSF1 |
| PI3K-Akt signaling pathway | LOC608458,CDC37,CSH,PIK3AP1,COMP,CSF3R,SGK2,CHAD,CSF1R,EFNA4 |
| Axon guidance | JAK1,Unc5b,EPHA4A,ROCK1,TRIO,CNKSR1,FGF8B,ARHGEF28,FES,DPYSL2B |
Protein Function
Efna2 has several biochemical functions, for example, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Efna2 itself. We selected most functions Efna2 had, and list some proteins which have the same functions with Efna2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ephrin receptor binding | EFNB1,EFNB3B,EFNA5,EFNB2B,EFNA4,CDK5R1,CBL,EPHA7,SDCBP,EFNA1B |
Interacting Protein
Efna2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efna2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efna2.
Chn2;Epha1
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References
- Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).
- Pentheroudakis, G; Kotoula, V; et al. Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. BMC CANCER 13:-(2013).
