• Official Full Name


  • Background

    This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.
  • Synonyms

    EFNA2; ephrin-A2; EPLG6; ELF 1; LERK6; EFNA 2; EFNA2_HUMAN; ELF1; Eph related receptor tyrosine kinase ligand 6; EPH-related receptor tyrosine kinase ligand 6; EphrinA2; HEK7 L; HEK7 ligand; HEK7-L; HEK7L; LERK-6; Ligand of eph related kinase 6; ELF-1;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Cell & Tissue Lysates
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Price
    Human EFNA2-978H Active Recombinant Human EFNA2 Protein, Fc Chimera Mammalian cells Fc
    Human EFNA2-28624TH Recombinant Human EFNA2 Wheat Germ N/A
    Human EFNA2-3098H Recombinant Human EFNA2 Protein, GST-tagged Wheat Germ GST
    Human EFNA2-1381H Recombinant Human EFNA2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EFNA2-3054H Recombinant Human EFNA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EFNA2-137HF Recombinant Full Length Human EFNA2 Protein In Vitro Cell Free System
    Human EFNA2-1407H Recombinant Human EFNA2 Protein, His-tagged E.coli N-His
    Human EFNA2-52H Recombinant Human EFNA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human EFNA2-4216HF Recombinant Full Length Human EFNA2 Protein, GST-tagged In Vitro Cell Free System GST
    Human EFNA2-52H-B Recombinant Human EFNA2 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Efna2-431M Active Recombinant Mouse Ephrin A2, His-tagged Mammalian cells His
    Mouse Efna2-4047M Active Recombinant Mouse Efna2 protein, His-tagged HEK293 His
    Mouse Efna2-4048M Recombinant Mouse Efna2, None tagged Human Cell N/A
    Mouse Efna2-1731M Recombinant Mouse Ephrin A2 Mammalian cells N/A
    Mouse EFNA2-2004MCL Recombinant Mouse EFNA2 cell lysate Human Cell N/A
    Mouse Efna2-2754M Recombinant Mouse Efna2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Efna2-2669M Recombinant Mouse Efna2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Efna2-2669M-B Recombinant Mouse Efna2 Protein Pre-coupled Magnetic Beads HEK293
    Rat Efna2-361R Active Recombinant Rat Efna2 Protein, Fc-tagged HEK293 Fc
    Chicken EFNA2-6541C Recombinant Chicken EFNA2 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • Efna2 Related Articles
    • Efna2 Related Research Area

    Efna2 involved in several pathways and played different roles in them. We selected most pathways Efna2 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efna2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental BiologyEFNA3B;SPRED3;FRS2A;NTN1A;ARPC2;CNKSR1;MED26;CLTB;PHB
    EPH-ephrin mediated repulsion of cellsEPHA2;EFNA1A;EFNA5;EFNB3B;EPHB4B;EPHB3A;EFNA1B;EFNA2;AP2B1
    EPHA-mediated growth cone collapseSHB;EPHA10;EFNA2A;EFNA5;EPHA4A;MYL9;KDR;EPHA2A;EPHA2
    PI3K-Akt signaling pathwayEFNA2;PRP2;EFNA4;COMP;CSF1;CSH2;PIK3AP1;CSH1;CDC37
    Rap1 signaling pathwayEFNA4;PFN4;CSF1;LOC608458;EFNA2;RGS14

    Efna2 has several biochemical functions, for example, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Efna2 itself. We selected most functions Efna2 had, and list some proteins which have the same functions with Efna2. You can find most of the proteins on our site.

    Function Related Protein
    ephrin receptor bindingCDK5;EFNA2;EFNA5B;EFNA3B;EFNA1A;EFNA5;SRC;EFNA2A;ANKS1B

    Efna2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efna2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efna2.

    Chn2; Epha1

    Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).
    Pentheroudakis, G; Kotoula, V; et al. Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. BMC CANCER 13:-(2013).
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