Efna2 Protein


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Official Full Name ephrin-A2
Background This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm.
Synonyms EFNA2; ephrin-A2; EPLG6; ELF 1; LERK6; EFNA 2; EFNA2_HUMAN; ELF1; Eph related receptor tyrosine kinase ligand 6; EPH-related receptor tyrosine kinase ligand 6; EphrinA2; HEK7 L; HEK7 ligand; HEK7-L; HEK7L; LERK-6; Ligand of eph related kinase 6; ELF-1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EFNA2-1381H Recombinant Human EFNA2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EFNA2-28624TH Recombinant Human EFNA2 Wheat Germ N/A
    Human EFNA2-3054H Recombinant Human EFNA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EFNA2-3098H Recombinant Human EFNA2 Protein, GST-tagged Wheat Germ GST
    Human EFNA2-978H Recombinant Human EFNA2 Protein, Fc Chimera Mammalian cells Fc
    Mouse Efna2-1731M Recombinant Mouse Ephrin A2 Mammalian cells N/A
    Mouse EFNA2-2004MCL Recombinant Mouse EFNA2 cell lysate Human Cell N/A
    Mouse Efna2-2754M Recombinant Mouse Efna2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Efna2-4047M Recombinant Mouse Efna2, His tagged Human Cell His
    Mouse Efna2-4048M Recombinant Mouse Efna2, None tagged Human Cell N/A
    Mouse Efna2-431M Recombinant Mouse Ephrin A2, His-tagged Mammalian cells His
    Rat Efna2-361R Recombinant Rat Efna2 Protein, Fc-tagged HEK293 Fc
    Chicken EFNA2-6541C Recombinant Chicken EFNA2 Mammalian Cell His

    Efna2 involved in several pathways and played different roles in them. We selected most pathways Efna2 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efna2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance KALRN; CFL2; ARPC2; SPTA1; PEA15; KCNQ3; NCK1; ROCK2; DCC; COL4A3
    Developmental Biology CSNK2A2; NADL1.1; CARM1; PLXNC1; SCN3B; FOXD3; EFNB3B; CAP2; MED18; DLG3
    EPH-Ephrin signaling EPHA2A; EPHA10; AP2B1; EPHB3A; ARPC1A; ACTR2; AP2S1; MYL12B; ARPC3; EPHA4A
    EPH-ephrin mediated repulsion of cells EPHA10; EFNB1; EFNB3; EFNA3B; EFNA1A; EFNA1B; EPHB4B; EFNA1; EPHB3A; AP2A2
    EPHA forward signaling BLK; ARHGEF15; EFNA1; EFNA2; EFNA3; EPHA2; CRKL; EFNA5
    EPHA-mediated growth cone collapse EFNA2A; EFNA3; EPHA2; SHB; EPHA2A; MYL9; EPHA10; KDR; EFNA1; EFNA1A
    PI3K-Akt signaling pathway EFNA3; CSH; CSH2; CHAD; CDC37; LAMC3; LOC608458; CSF1R; PRP2; CSF3R
    Rap1 signaling pathway EFNA2; LOC608458; RGS14; PFN4; EFNA4; CSF1

    Efna2 has several biochemical functions, for example, ephrin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Efna2 itself. We selected most functions Efna2 had, and list some proteins which have the same functions with Efna2. You can find most of the proteins on our site.

    Function Related Protein
    ephrin receptor binding EFNB2; CRK; EFNA3; FYN; SHC1; EFNA1B; EFNA2; SIPA1L1; NTRK1; EFNA1

    Efna2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efna2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efna2.

    Chn2; Epha1

    Strimpakos, A; Pentheroudakis, G; et al. The Prognostic Role of Ephrin A2 and Endothelial Growth Factor Receptor Pathway Mediators in Patients With Advanced Colorectal Cancer Treated With Cetuximab. CLINICAL COLORECTAL CANCER 12:267-274(2013).
    Pentheroudakis, G; Kotoula, V; et al. Biomarkers of benefit from cetuximab-based therapy in metastatic colorectal cancer: interaction of EGFR ligand expression with RAS/RAF, PIK3CA genotypes. BMC CANCER 13:-(2013).

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