Efnb2
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Official Full Name
Ephrin-B2
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Overview
Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. -
Synonyms
EPHB2; EPH receptor B2; DRT; EK5; ERK; CAPB; Hek5; PCBC; EPHT3; Tyro5; MGC87492; ephrin type-B receptor 2; EPH-like kinase 5; eph tyrosine kinase 3; elk-related tyrosine kinase; protein-tyrosine kinase HEK5; tyrosine-protein kinase TYRO5; renal carcinoma antigen NY-REN-47; tyrosine-protein kinase receptor EPH-3; developmentally-regulated Eph-related tyrosine kinase; EphB2; EC=2.7.10.1; Developmentally-regulated Eph-related tyrosine kinase; CAPB; PCBC; EFN B2; EFNB 2; EFNB2; Eph related receptor tyrosine kinase ligand 5; EPH-related receptor tyrosine kinase ligand 5; Ephrin-B2; EphrinB2; EPLG 5; EPLG5; Htk L; HTK ligand; HTK-L; HTKL; LERK 5; LERK-5; LERK5; Ligand of eph related kinase 5 antibody; MGC126226; MGC126227; MGC126228; OTTMUSP00000024973; Htk-L; ELF-2; NLERK-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canine
- Chicken
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- E.coli
- E.coli expression system
- HEK293
- HEK293E
- HEK293F
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- hFc
- His
- Fc
- GST
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
Efnb2 involved in several pathways and played different roles in them. We selected most pathways Efnb2 participated on our site, such as Axon guidance, Developmental Biology, EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with Efnb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | EFNB3;NFATC3;GDNF;SPTBN2;CLTB;JAK3;RASGRP4;SPNA2;ACTR2B |
| Developmental Biology | MEF2AA;ADAM23;CNTN1;MED21;DOCK1;SALL4;EZRA;ARPC1A;CDON |
| EPH-Ephrin signaling | ACTR2;EFNB3B;EPHB4B;EFNA3B;ARPC4;AP2S1;AP2A2;ACTR3;EFNA1 |
| EPH-ephrin mediated repulsion of cells | AP2B1;AP2A2;EFNB2;EFNB2A;EFNA1;EFNA4;EFNA2A;EFNA2;CLTB |
| EPHB forward signaling | EFNB1;EFNB3;ITSN1;EFNA5;GRB7;EFNB2 |
| EPHB-mediated forward signaling | ARPC4;EPHB4B;ARPC5;EFNB1;EFNB2A;ARPC3;ARPC1B;ACTR3;ARPC1A |
| Ephrin B reverse signaling | EFNB2;PTPN13;EFNB1 |
| Ephrin signaling | EPHB3A;EFNB3;EFNB1;EFNB2;SDCBP;EPHB4A;EPHB4B;EFNB3B;EFNB2A |
Efnb2 has several biochemical functions, for example, ephrin receptor binding, protein binding, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Efnb2 itself. We selected most functions Efnb2 had, and list some proteins which have the same functions with Efnb2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ephrin receptor binding | SHC1;PIK3CG;CDK5;EFNA3B;EFNA3;EFNB2B;CBL;CRK;EFNA2 |
| protein binding | FIGNL1;KAT5;HOOK3;INHBB;TRIP4;PEX14;FAM192A;MRM1;PHF10 |
| virus receptor activity | ICAM1;CD80;ITGB7;EFNB3;ITGB5;SLC52A2;PVRL1;SLC20A2;CR2 |
Efnb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Efnb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Efnb2.
NCK2
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewDuring the experiment, the technician helped me solve the problems in a timely and accurate manner.
The EFNB2 proteins purchased from your company is suitable for WB.
Received high quality protein products and obtained satisfactory experimental results.
Q&As (6)
Ask a questionEphB6 overexpression up-regulates the expression of its ligand EFNB2.
EFNB2 is associated with breast, colon, bladder, cervical and other cancers.
EFNB2 is involved in tissue plasticity, tumorigenesis, and other biological processes.
EFNB2 is widely expressed in tumor vasculature.
EFNB2 promotes BUC cell proliferation by inhibiting apoptosis in BUC cells.
EFNB2 is one of the physiological ligands of EphB6 that functions by binding to EphB6.
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