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Official Full Name eukaryotic translation initiation factor 2-alpha kinase 3
Background PERK (PKR-like ER kinase) is a single-pass type I ER membrane protein with a stress-sensing luminal domain connected by a transmembrane segment to a cytoplasmic-kinase domain.
Synonyms EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3; PEK; PERK; hsPEK; pancreatic EIF2-alpha kinase; PRKR-like endoplasmic reticulum kinase; eukaryotic translation initiation factor 2 alpha kinase 3; WRS; DKFZp781H1925
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human EIF2AK3-1010H Recombinant Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3, GST-tagged E.coli GST
    Human EIF2AK3-1020H Recombinant Human EIF2AK3 Protein, His-tagged E.coli His
    Human EIF2AK3-2744H Recombinant Human EIF2AK3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human EIF2AK3-30644TH Recombinant Human EIF2AK3 E.coli N/A
    Human EIF2AK3-3150H Recombinant Human EIF2AK3 Protein, GST-tagged E.coli GST
    Human EIF2AK3-3151H Recombinant Human EIF2AK3 Protein, GST-tagged Wheat Germ GST
    Human EIF2AK3-337H Recombinant Human EIF2AK3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human EIF2AK3-6673HCL Recombinant Human EIF2AK3 293 Cell Lysate HEK293 N/A
    Mouse Eif2ak3-1392M Recombinant Mouse Eif2ak3 protein, His & T7-tagged E.coli His/T7
    Mouse Eif2ak3-2772M Recombinant Mouse Eif2ak3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat EIF2AK3-2045R Recombinant Rat EIF2AK3 Protein Mammalian Cell His

    eif2ak3 involved in several pathways and played different roles in them. We selected most pathways eif2ak3 participated on our site, such as Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with eif2ak3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein processing in endoplasmic reticulum MBTPS2; BCAP31; HSPA5; UBE2E2; SAR1AB; SAR1B; STT3A; UBE2J2; CUL1B; ATF4
    Non-alcoholic fatty liver disease (NAFLD) TNFRSF1A; NDUFA6; NDUFC1; MAP3K11; COX7A1; UQCR11; COX7B; COX7A2; RXRA; IL-8
    Alzheimers disease NDUFS2; COX8A; COX5B; COX7A1; COX6A2; ATP5B; NDUFB5; LPL; NOS1; NDUFC2-KCTD14
    Hepatitis C NFKB1; OAS2; EIF2AK2; BRAF; MAPK12; OAS3; NR1H3; CLDN10; IFNA6; CLDN15
    Measles IFNA1; OAS3; FYN; MAVS; TNFRSF10B; NFKBIB; IFNA4; DOK1; SH2D1A; Ifna11
    Influenza A CXCL8; LOC780933; PYCARD; MX1; PIK3CB; DDX39B; NLRX1; PIK3R2; PRKCA; NXT2
    Herpes simplex infection SRSF2B; C3A.2; CASP3A; IRF3; TNFB; BLB2; MHC1UXA2; CLOCKB; HLA-DMA; BF2
    Epstein-Barr virus infection HLA-DRB4; PIK3CD; POLR2K; POLR2H; TP53; YWHAH; MAP2K6; MAPK11; MAPK13; TAB2

    eif2ak3 has several biochemical functions, for example, ATP binding, Hsp90 protein binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by eif2ak3 itself. We selected most functions eif2ak3 had, and list some proteins which have the same functions with eif2ak3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding RPS6KA6; MYO5A; DDX56; AAK1; RAD51L1; SGK2A; PET112L; KCNJ10; MSH5; APAF1
    Hsp90 protein binding CDC37; NASP; HDAC6; PPEF2; AHR; NPAS2; STUB1; ARNTL; FKBP6; ERBB2
    enzyme binding ATF7; PPP1R3D; STUB1; EIF2AK3; ZFHX3; PLSCR4; CLSTN2; CBS; PARP4; UBE2I
    eukaryotic translation initiation factor 2alpha kinase activity EIF2AK2; EIF2AK3; EIF2AK4; ALPK2; EIF2AK1
    identical protein binding HCFC1; YWHAZ; C1S; SMURF2; WAS; DRD2; ATL3; CBX3; DPP9; MAP3K13
    protein binding MRPL44; APPL1; MKI67; ECM1; RIMS2; KDM5A; PLXNB2; SEMA4D; GRM1; UBE2L6
    protein homodimerization activity CASQ2; ASNS; ENPP1; XPNPEP1; KLRB1B; CDSN; ACTN3; NRF1; GABPB2; ERBB4
    protein kinase activity NEK10; MAP3K11; EPHA1; TNNI3K; KDRL; DYRK3; PRKCHB; MAP3K2; PDK4; RPS6KAL
    protein phosphatase binding TRAF2; LCK; JAK3; ITPR1; VCP; AP3B1; STAT3; FGF19; DRD1; JAK1
    protein serine/threonine kinase activity HIPK1; SGK2B; ZNF143B; BMPR1AB; ULK4; STK4; WNK1; LIMK1; OXSR1B; SGK2

    eif2ak3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with eif2ak3 here. Most of them are supplied by our site. Hope this information will be useful for your research of eif2ak3.

    HSPA5; HSP90B1; aroE; BCL6

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