EIF2AK3

  • Official Full Name

    eukaryotic translation initiation factor 2-alpha kinase 3
  • Overview

    PERK (PKR-like ER kinase) is a single-pass type I ER membrane protein with a stress-sensing luminal domain connected by a transmembrane segment to a cytoplasmic-kinase domain.
  • Synonyms

    EIF2AK3;eukaryotic translation initiation factor 2-alpha kinase 3;PEK;PERK;hsPEK;pancreatic EIF2-alpha kinase;PRKR-like endoplasmic reticulum kinase;eukaryotic translation initiation factor 2 alpha kinase 3;WRS;DKFZp781H1925

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • E.coli
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • GST
  • His
  • T7
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
EIF2AK3-3150H Active Recombinant Human EIF2AK3 Protein, GST-tagged E.coli Human GST 536-1116 a.a.
EIF2AK3-1010H Recombinant Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3, GST-tagged E.coli Human GST 563-1115 a.a.
Eif2ak3-1392M Recombinant Mouse Eif2ak3 protein, His & T7-tagged E.coli Mouse His&T7 Met973~Asn1114
EIF2AK3-2045R Recombinant Rat EIF2AK3 Protein Mammalian Cells Rat His
EIF2AK3-30644TH Recombinant Human EIF2AK3 E.coli Human Non 554 amino acids
EIF2AK3-3151H Recombinant Human EIF2AK3 Protein, GST-tagged Wheat Germ Human GST
EIF2AK3-337H Recombinant Human EIF2AK3 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
EIF2AK3-6673HCL Recombinant Human EIF2AK3 293 Cell Lysate HEK293 Human Non
EIF2AK3-013H Recombinant Human eukaryotic translation initiation factor 2-alpha kinase 3 Protein, His tagged E.coli Human His 95-420aa
EIF2AK3-1020H Recombinant Human EIF2AK3 Protein, His-tagged E.coli Human His 536-1116 a.a.
EIF2AK3-1413H Recombinant Human EIF2AK3 Protein, His-tagged E.coli Human His Phe593-Phe1077
EIF2AK3-1702R Recombinant Rat EIF2AK3 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
EIF2AK3-1702R-B Recombinant Rat EIF2AK3 Protein Pre-coupled Magnetic Beads HEK293 Rat
EIF2AK3-186HFL Active Recombinant Full Length Human EIF2AK3 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
EIF2AK3-2744H Recombinant Human EIF2AK3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
Eif2ak3-2772M Recombinant Mouse Eif2ak3 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
EIF2AK3-819H Recombinant Human EIF2AK3 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
EIF2AK3-819H-B Recombinant Human EIF2AK3 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    EIF2AK3 involved in several pathways and played different roles in them. We selected most pathways EIF2AK3 participated on our site, such as Protein processing in endoplasmic reticulum,Non-alcoholic fatty liver disease (NAFLD),Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF2AK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease CAPN2,AKR1C1,BACE1,MAPK1,CALM2,GAPDH,ATP5C1,NDUFA8,TNF,NDUFA3
    Epstein-Barr virus infection PIK3R2,TRADD,ENTPD3,RIPK1,HDAC2,TRAF3,YWHAE,TBPL1,YWHAZ,SPN
    Protein processing in endoplasmic reticulum MAPK8A,ATXN3,SSR2,SSR4,NGLY1,SEC24B,HSPA1B,CAPN2B,BAX,HSPA5
    Non-alcoholic fatty liver disease (NAFLD) NDUFA9,MAP3K11,NR1H3,INS1,NDUFS2,NDUFB7,PRKAG3,MAPK9,SREBF1,NDUFA6
    Herpes simplex infection MYD88,OAS1B,HLA-DPB1,STAT1B,IFNA8,TRAF2,FAS,SFRS9,PTPN11,IFNA2
    Influenza A HSPA6,IFNAR1,PRSS3,TNFRSF10A,HLA-DPB1,MAPK10,MAP2K4,TLR7,EIF2AK4,OAS1
    Measles HSPA1B,TLR9,CCNE2,PIK3R3,IFNA2,HSPA6,IFNA5,OAS1B,CD3E; CD3D,CD3D
    Hepatitis C TYK2,PDPK1,IRF7,IFNB1,IFNA12,IFNA2,PPP2R2B,CLDN6,CLDN4,EIF2AK2

    Protein Function

    EIF2AK3 has several biochemical functions, for example, ATP binding,Hsp90 protein binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF2AK3 itself. We selected most functions EIF2AK3 had, and list some proteins which have the same functions with EIF2AK3. You can find most of the proteins on our site.

    Function Related Protein
    protein serine/threonine kinase activity GRK5,PRKCE,BCKDK,TGFBR1B,NEK12,MAP3K4,ADCK5,PRKACBB,MAP3K8,STK36
    Hsp90 protein binding PACRG,HDAC6,USP19,FKBP6,CSNK2A1,HIF1A,NASP,GBP1,STUB1,ERN1
    protein homodimerization activity GCH1,LRP6,DGAT2,APOC2,FZD1,NR4A2,FAM109A,SEPT12,SNF8,PVRL2
    identical protein binding VAMP2,CHEK2,RCAN1,GAPDH,SCHIP1,COL2A1,CHAF1A,ERBB2,SHANK3,AXIN1
    ATP binding SIK2,RAD51B,MAPK8,ABCD3B,CAMK2D,ABCB10,MST1R,SMC3,MTOR,GTF2F2B
    eukaryotic translation initiation factor 2alpha kinase activity EIF2AK2,ALPK2,EIF2AK1,EIF2AK4
    protein phosphatase binding PPP1R3C,VRK3,CDKN1B,KCNN4,MET,SHOC2,ROS1,AP3B1,PIK3R1,ERBB2
    protein binding TXNL4B,CALM2,BCL11A,TNFSF14,HLA-DRB3,PSKH1,AHNAK2,JPH2,CLSTN1,PRNP
    protein kinase activity CSF1RA,PLK5,MAP2K4,CAMK1GA,FYNB,WEE2,MAPK8B,LMTK2,RPS6KA3,CSNK2A2A

    Interacting Protein

    EIF2AK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF2AK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF2AK3.

    HSPA5;HSP90B1;aroE;BCL6

    Resources

    References

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