EIF5

  • Official Full Name

    eukaryotic translation initiation factor 5
  • Overview

    Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of;bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S initiation complex. The resulting;functional 80S ribosomal initiation complex is then active in peptidyl transfer and chain elongations (summary by Si;et al., 1996 (PubMed 8663286)).
  • Synonyms

    EIF5;eukaryotic translation initiation factor 5;eIF-5;EIF-5A

Recombinant Proteins

  • Chicken
  • Rat
  • Human
  • Zebrafish
  • Mouse
  • Mammalian Cells
  • Wheat Germ
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
  • SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
EIF5-1627C Recombinant Chicken EIF5 Mammalian Cells Chicken His
EIF5-2069R Recombinant Rat EIF5 Protein Mammalian Cells Rat His
EIF5-27177TH Recombinant Human EIF5 protein, GST-tagged Wheat Germ Human GST 1-431 a.a.
EIF5-8633H Recombinant Human EIF5 protein(Met1-Asp150), GST-tagged E.coli Human GST Met1-Asp150
EIF5-9994Z Recombinant Zebrafish EIF5 Mammalian Cells Zebrafish His
EIF5-6642HCL Recombinant Human EIF5 293 Cell Lysate HEK293 Human Non
EIF5-1726R Recombinant Rat EIF5 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
EIF5-1726R-B Recombinant Rat EIF5 Protein Pre-coupled Magnetic Beads HEK293 Rat
Eif5-2791M Recombinant Mouse Eif5 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
EIF5-3395H Recombinant Human EIF5 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
EIF5-478H Recombinant Human EIF5 Protein (1-431 aa), His-SUMO-tagged E.coli Human His&SUMO 1-431 aa
EIF5-6913HF Recombinant Full Length Human EIF5 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 431 amino acids

    Involved Pathway

    EIF5 involved in several pathways and played different roles in them. We selected most pathways EIF5 participated on our site, such as Cap-dependent Translation Initiation,Eukaryotic Translation Initiation,GTP hydrolysis and joining of the 60S ribosomal subunit, which may be useful for your reference. Also, other proteins which involved in the same pathway with EIF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Eukaryotic Translation Initiation EIF2S1A,EIF4A1,EIF2B1,EIF1AX,EIF4H,EIF2S3,EIF4EB,EIF4B,EIF2S1,EIF3K
    Cap-dependent Translation Initiation EIF1AXA,EIF2B1,EIF2S1A,EIF2S1,EIF4E,EIF4A2,EIF2S3,RPL35,EIF4EB,EIF4EBP1
    RNA transport NUP107,EIF1AY,SUMO3A,EIF2S3Y,SIP1,EIF3A,EIF2B4,ELAC1,EEF1A2,SNUPN
    Translation APEH,EEF1D,EEF1A2,EIF2B1,EEF1B2,EEF1G
    Gene Expression ZNF23,MED31,COBRA1,EIF2C3,CSTF2,ZNF180,ZNF92,LAGE3,LSM10,SKIA
    GTP hydrolysis and joining of the 60S ribosomal subunit EIF3K,EIF1AXA,EIF2S3,RPL35,EIF4H,EIF4B,EIF4A1,EIF1AX,EIF2S1,EIF4A2
    Metabolism of proteins IGFBP6,ADAMTS18,GALNTL2,CPN1,NAT8,DCP2,PCSK1,CPB2,BCS1L,TUBA1B
    Ribosomal scanning and start codon recognition EIF4H

    Protein Function

    EIF5 has several biochemical functions, for example, GTP binding,GTPase activity,poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EIF5 itself. We selected most functions EIF5 had, and list some proteins which have the same functions with EIF5. You can find most of the proteins on our site.

    Function Related Protein
    poly(A) RNA binding PRR3,RPL37A,PRPF40A,RPL27A,PRMT1,CPSF6,MAGOH2,FNDC3B,TTC6,CDK5R2
    protein binding GLI2,DUSP15,LOC149950,NFE2L1,BIRC2,TFIP11,MYO5B,GPR158,SCEL,RAB6A
    GTP binding NOA1,AGAP2,SPAG1,RAB18B,GPN2,RAB1,RHOAA,RAB34,TRIM66,RAB38
    translation initiation factor activity EIF6,EIF3E,EIF3J,EIF4G1,EIF4H,EIF3EB,EIF2S3Y,AGO2,EIF4G2,MTIF3
    GTPase activity NKIRAS1,TRIM23,RAB43,IFT22,DNAJC27,RAB1B,GNA11A,GNA15.1,GNAT3,RAB40C
    translation factor activity, RNA binding CPEB1A,EIF4A1,ABCF1,CPEB1,CPEB2,EIF4H,CPEB1B,EEF1A2,EIF4E2,CPEB3

    Interacting Protein

    EIF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EIF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of EIF5.

    DUSP12;EIF1AX;IKBKE;HSPB1;PUM1;ptrB;NRGN;DDX3X;FN1

    Resources

    References

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