erbb3

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erbb3

Official Full Name ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Background ErbB3 is a member of the EGFR/erbB receptor tyrosine kinase family. ErbB3 lacks intrinsic kinase activity due to an amino acid substitution within the ATP binding site. Upon heterodimerization with the other erbB family members, erbB3 becomes phosphorylated at multiple tyrosine residues that represent docking sites for downstream signaling proteins, e.g. PI3K, grb7 and shc. The erbB3 cytoplasmic domain contains 6 docking sites for PI3K. Thus, erbB3 is a potent activator of the PI3K/PKB signaling pathway.
Synonyms ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • NSO
    • Wheat Germ
    • Tag :
    • DDK
    • His
    • Fc
    • GST
    • His-Avi
    • Myc/DDK
    • Myc
    • N/A
    • Thyrodoxin
    • Twin-Strep
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ERBB3-23H Recombinant Human ERBB3 Protein E.coli N/A
    Human ERBB3-084H Recombinant Human ERBB3 protein, His-Avi-tagged HEK293 His-Avi
    Human ERBB3-1765H Recombinant Human ERBB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ERBB3-1933H Recombinant Human ERBB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ERBB3-284H Recombinant Human ERBB3 Protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Mouse Erbb3-7201M Recombinant Mouse Erbb3 Protein, His-tagged Insect Cell His
    Mouse Erbb3-970M Recombinant Mouse Erbb3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ERBB3-105H Recombinant Human ERBB3, His-tagged Insect Cell His
    Human ERBB3-1216H Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), His-tagged E.coli His
    Human ERBB3-127H Recombinant Human ERBB3 Protein, DDK/His-tagged HEK293 DDK/His
    Human ERBB3-128H Recombinant Human ERBB3 Protein, DDK-tagged Insect Cell DDK
    Human ERBB3-1613H Recombinant Human ERBB3 NSO N/A
    Human ERBB3-196H Recombinant Human ERBB3, His-tagged, C13&N15 Labeled HEK293 His
    Human ERBB3-197H Recombinant Human ERBB3 Protein HEK293 N/A
    Human ERBB3-207H Recombinant Human ERBB3, His-tagged HEK293 His
    Human ERBB3-209H Recombinant Human ERBB3, His tagged Human Cell His
    Human ERBB3-2117H Recombinant Human ERBB3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ERBB3-232H Recombinant Human ERBB3, C13&N15-labeled HEK293 N/A
    Human ERBB3-2514H Recombinant Human V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian) HEK293 N/A
    Human ERBB3-26847TH Recombinant Human ERBB3, His-tagged E.coli His
    Human ERBB3-283H Recombinant Human ERBB3, His-tagged, Biotinylated HEK293 His
    Human ERBB3-3448H Recombinant Human ERBB3 Protein, GST-tagged Wheat Germ GST
    Human ERBB3-383H Recombinant Human ERBB3 Protein, His-tagged E.coli His
    Human ERBB3-430HCL Recombinant Human ERBB3 cell lysate Insect Cell N/A
    Human ERBB3-44H Recombinant Human ERBB3, Fc tagged Human Cell Fc
    Human ERBB3-45H Recombinant Human ERBB3 Protein, Twin-Strep tagged HEK293 Twin-Strep
    Human ERBB3-5193H Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged Human Thyrodoxin/His
    Human ERBB3-621H Recombinant Human ERBB3, Fc-tagged, Biotinylated Human Cell Fc
    Human ERBB3-7276H Recombinant Human ERBB3, His & GST tagged Insect Cell His/GST
    Human ERBB3-939HCL Recombinant Human ERBB3 cell lysate Human Cell N/A
    Mouse ERBB3-1765MCL Recombinant Mouse ERBB3 cell lysate Human Cell N/A
    Mouse Erbb3-2515M Recombinant Mouse Erbb3, His tagged Human Cell His
    Mouse Erbb3-384M Recombinant Mouse Erbb3 Protein, His-tagged E.coli His
    Mouse ERBB3-38M Recombinant Mouse ERBB3 Protein, His-tagged Insect Cell His
    Mouse Erbb3-470M Recombinant Mouse V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Fc-tagged NS0 Fc
    Rat ERBB3-1415RCL Recombinant Rat ERBB3 cell lysate Human Cell N/A
    Rat ERBB3-2133R Recombinant Rat ERBB3 Protein Mammalian Cell His
    Rat Erbb3-7436R Recombinant Rat Erbb3, Fc tagged Human Cell Fc
    Rat Erbb3-7437R Recombinant Rat Erbb3, His tagged Human Cell His
    Rhesus Macaque ERBB3-1178R Recombinant Rhesus ERBB3 Protein, Fc-tagged HEK293 Fc
    Rhesus Macaque ERBB3-1179R Recombinant Rhesus ERBB3 Protein, His-tagged HEK293 His
    Rhesus Macaque ERBB3-1180R Recombinant Rhesus ERBB3 Protein HEK293 N/A
    Rhesus Macaque ERBB3-1721RCL Recombinant Rhesus ERBB3 cell lysate Human Cell N/A
    Chicken ERBB3-3461C Recombinant Chicken ERBB3 Mammalian Cell His

    erbb3 involved in several pathways and played different roles in them. We selected most pathways erbb3 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with erbb3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathway ERBB4A; PIK3R3B; HRASB; NRG2; RAF1A; AKT2; PRKCA; GRB2A; AKT3A; MAP2K7
    Calcium signaling pathway PDE1A; PPIF; GRIN1A; ITPKB; P2RX3B; PDE1C; SPHK1; PPP3CCA; PRKACAB; HTR2C
    Endocytosis IL2RG; ARRB1; CYTH2; ARF5; HSPA1B; PML; CHMP2BB; ARPC5A; KIF5C; ARR3B
    Proteoglycans in cancer WNT2B; IL12B; ITGB5; HRAS; Casp3; KRAS; NRAS; ERBB3; CAMK2G; SDC2
    MicroRNAs in cancer TIMP3; TPM1; SOS1; KRAS; PDCD4; NOTCH4; MET; IRS2; ATM; GLS

    erbb3 has several biochemical functions, for example, ATP binding, growth factor binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by erbb3 itself. We selected most functions erbb3 had, and list some proteins which have the same functions with erbb3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ACTB2; KLHL8; CTPS2; CDK19; HK3; LARS2; MCM6; TK2; TRIT1; PHKG2
    growth factor binding LIFR; NKD2; IGFBP2B; TEK; KDR; FLT4; ACVR2B; GHRHR; REG3B; LTBP2
    identical protein binding CLDN2; BAX; HSP90AA1; SOD2; DCP1A; SERPINA1A; PVRL2; COL1A2; RABAC1; PRMT1
    protein binding SMARCA4; KL; SOX13; KBTBD7; STT3A; UBA5; GAN; ROPN1; ABCF1; PRKCE
    protein heterodimerization activity SLC51A; PIK3R1; MEF2C; DRD1; SYT14; NFE2L2A; SRY; CYBA; BCL2; GCLC
    protein homodimerization activity DARS2; PARK7; APOBEC3G; FOXP2; PRDM6; PEX11A; PDCD10; TFRC; SPPL3; ENG
    protein tyrosine kinase activator activity AFAP1L2; NRG1; ABI1; ABI3A; GHRL; ABI1A; PAK2; ERBB3; CD24; GAS6
    NOT protein tyrosine kinase activity ERBB3; TWF1; RYK; KLHL8
    transmembrane signaling receptor activity LGR6; GHRHRA; CLDN4; CLEC4A; SELE; TLR7; TNFRSF11A; CELSR3; TLR3; CD5

    erbb3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with erbb3 here. Most of them are supplied by our site. Hope this information will be useful for your research of erbb3.

    ERBB2

    Huang, Z; Choi, BK; et al. The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling. ONCOGENE 34:1105-1115(2015).
    Nevoltris, D; Lombard, B; et al. Conformational Nanobodies Reveal Tethered Epidermal Growth Factor Receptor Involved in EGFR/ErbB2 Predimers. ACS NANO 9:1388-1399(2015).

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