ERBB3

  • Official Full Name

    ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

  • Overview

    ErbB3 is a member of the EGFR/erbB receptor tyrosine kinase family. ErbB3 lacks intrinsic kinase activity due to an amino acid substitution within the ATP binding site. Upon heterodimerization with the other erbB family members, erbB3 becomes phosphorylated at multiple tyrosine residues that represent docking sites for downstream signaling proteins, e.g. PI3K, grb7 and shc. The erbB3 cytoplasmic domain contains 6 docking sites for PI3K. Thus, erbB3 is a potent activator of the PI3K/PKB signaling pathway.
  • Synonyms

    ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Monkey
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • 6×His
  • Fc
  • hFc
  • His
  • Avi
  • mFc
  • DDDDK
  • DDK
  • DDK|His
  • Flag
  • GST
  • His (Fc)
  • His(C
  • ter)
  • LEVLFQ
  • Myc
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Strep
  • Tag Free
  • Thyrodoxin|His
  • Twin
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ERBB3-621H Active Recombinant Human ERBB3, Fc-tagged, Biotinylated Human Cell Fc
Human ERBB3-2396H Recombinant Human ERBB3 protein(Met1-Thr643), His&Avi-tagged, Biotinylated HEK293 C-His&Avi Met1-Thr643
Human ERBB3-056H Active Recombinant Human ERBB3 Protein, His & GST-tagged Insect Cells His/GST Pro 730-Ser 1065
Human ERBB3-45H Active Recombinant Human ERBB3 protein, Twin-Strep-tagged HEK293 Twin-Strep Ser20-Thr643
Human ERBB3-7276H Active Recombinant Human ERBB3 protein(Pro 730-Ser 1065), His&GST-tagged Insect Cells N-His&GST Pro 730-Ser 1065
Human ERBB3-197H Recombinant Human ERBB3 Protein HEK293 N/A Ser20~Thr643
Human ERBB3-232H Recombinant Human ERBB3, C13&N15-labeled HEK293 N/A
Human ERBB3-127H Recombinant Human ERBB3 Protein, DDK/His-tagged HEK293 DDK/His Ser20 - Thr643
Human ERBB3-209H Active Recombinant Human ERBB3(Met1-Thr643), His-tagged HEK293 C-His Met1-Thr643
Human ERBB3-3448H Recombinant Human ERBB3 Protein, GST-tagged Wheat Germ GST
Human ERBB3-105H Recombinant Human ERBB3, His-tagged Insect Cell His
Human ERBB3-128H Recombinant Human ERBB3 Protein, DDK-tagged Insect Cell DDK
Human ERBB3-26847TH Recombinant Human ERBB3, His-tagged E.coli His
Human ERBB3-44H Recombinant Human ERBB3 protein(Met1-Thr643), hFc-tagged HEK293 C-hFc Met1-Thr643
Human ERBB3-196H Recombinant Human ERBB3, His-tagged, C13&N15 Labeled HEK293 His
Human ERBB3-23H Active Recombinant Human ERBB3 Protein E.coli N/A
Human ERBB3-207H Recombinant Human ERBB3 Protein(Ser20-Thr643), His-Avi-tagged, FITC-Labeled HEK293 C-His-Avi Ser20-Thr643
Human ERBB3-1613H Recombinant Human ERBB3 Mammalian cells N/A
Human ERBB3-283H Active Recombinant Human ERBB3 protein, His-tagged, Biotinylated HEK293 His Ser20-Thr643
Human ERBB3-2514H Recombinant Human V-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian) HEK293 N/A
Human ERBB3-5193H Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Thyrodoxin Tagged and His Tagged Human Thyrodoxin/His
Human ERBB3-1216H Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), His-tagged E.coli His
Human ERBB3-430HCL Recombinant Human ERBB3 cell lysate Insect Cell N/A
Human ERBB3-939HCL Recombinant Human ERBB3 cell lysate Human Cell N/A
Human ERBB3-2117H Recombinant Human ERBB3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ERBB3-209HAF647 Recombinant Human ERBB3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 635
Human ERBB3-084H Recombinant Human ERBB3 protein, His-Avi-tagged HEK293 His-Avi It contains Ser 20 - Thr 643.
Human ERBB3-68H Recombinant Human ERBB3 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter) Ser20-Thr643
Human ERBB3-938H Recombinant Human ERBB3 protein, hFc-tagged, Biotinylated HEK293 hFc Met1-Thr643
Human ERBB3-209HF Active Recombinant Human ERBB3 protein, His-tagged, FITC-Labeled HEK293 His Ser20-Thr643
Human ERBB3-1765H Recombinant Human ERBB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ErbB3-1398H Active Recombinant Human ErbB3 protein, Fc-tagged HEK293 Fc Ser20-Thr643
Human ERBB3-197HAF488 Recombinant Human ERBB3 Protein, DDDDK-tagged, Alexa Fluor 488 conjugated HEK293 DDDDK 630
Human ErbB3-275HF Recombinant Human ERBB3 Protein, Fc-tagged, FITC conjugated HEK293 Fc 858
Human ERBB3-1933H Recombinant Human ERBB3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ERBB3-28H Active Recombinant Human ERBB3 Protein (Ser20-Gly538), C-6×His tagged HEK293 C-6×His Ser20-Gly538
Human ErbB3-275HAF555 Recombinant Human ERBB3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 858
Human ERBB3-4523HF Recombinant Full Length Human ERBB3 Protein, GST-tagged In Vitro Cell Free System GST 331 amino acids
Human ERBB3-209HAF555 Recombinant Human ERBB3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 635
Human ERBB3-4089H Recombinant Human ERBB3 Protein (Met1-Thr643), C-His tagged Mammalian cells C-His Met1-Thr643
Human ERBB3-44HAF555 Recombinant Human ERBB3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 862
Human ERBB3-123E Active Recombinant Human ERBB3 Fragment Protein (171 aa) E.coli 171
Human ERBB3-197HAF647 Recombinant Human ERBB3 Protein, DDDDK-tagged, Alexa Fluor 647 conjugated HEK293 DDDDK 630
Human ERBB3-284H Recombinant Human ERBB3 Protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ser 20 - Thr 643
Human ERBB3-7276HAF555 Recombinant Human ERBB3 Protein, His/GST-tagged, Alexa Fluor 555 conjugated Insect Cell His/GST 573
Human ERBB3-383H Recombinant Human ERBB3 Protein, His-tagged E.coli His Leu709~Thr966
Human ERBB3-44HAF488 Recombinant Human ERBB3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 862
Human ERBB3-43H Active Recombinant Human ERBB3(Met1-Thr643), mFc-tagged HEK293 C-mFc Met1-Thr643
Human ErbB3-275HAF647 Recombinant Human ERBB3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 858
Human ERBB3-209HAF488 Recombinant Human ERBB3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 635
Human ERBB3-197HF Recombinant Human ERBB3 Protein, DDDDK-tagged, FITC conjugated HEK293 DDDDK 630
Human ErbB3-275HAF488 Recombinant Human ERBB3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 858
Human ERBB3-44HAF647 Recombinant Human ERBB3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 862
Human ERBB3-7276HAF488 Recombinant Human ERBB3 Protein, His/GST-tagged, Alexa Fluor 488 conjugated Insect Cell His/GST 573
Human ERBB3-235H Recombinant Human ERBB3 Protein, His-tagged, Biotinylated HEK293 His 1342
Human ERBB3-197HAF555 Recombinant Human ERBB3 Protein, DDDDK-tagged, Alexa Fluor 555 conjugated HEK293 DDDDK 630
Human ERBB3-7276HAF647 Recombinant Human ERBB3 Protein, His/GST-tagged, Alexa Fluor 647 conjugated Insect Cell His/GST 573
Human ERBB3-236H Recombinant Human ERBB3 Protein, His-tagged HEK293 His 1342
Human ERBB3-237H Recombinant Human ERBB3 Protein, Fc-tagged HEK293 Fc 1342
Human ERBB3-238H Recombinant Human ERBB3 Protein, Strep-tagged HEK293 Strep 1342
Human ERBB3-44HF Recombinant Human ERBB3 Protein, Fc-tagged, FITC conjugated HEK293 Fc 862
Human ERBB3-2614H Recombinant Human ERBB3 Protein (Ser20-Cys331), C-Fc tagged Mammalian cells C-Fc Ser20-Cys331
Human ERBB3-858H-B Recombinant Human ERBB3 Protein Pre-coupled Magnetic Beads HEK293
Human ERBB3-02HM Recombinant Human ERBB3 Protein (E928G), His tagged Insect Cell
Human ERBB3-7276HF Recombinant Human ERBB3 Protein, His/GST-tagged, FITC conjugated Insect Cell His/GST 573
Human ERBB3-2615H Recombinant Human ERBB3 Protein (Met1-Thr643), C-Fc tagged Mammalian cells C-Fc Met1-Thr643
Human ERBB3-411HFL Recombinant Full Length Human ERBB3 Protein, C-Flag-tagged Mammalian cells Flag
Human ERBB3-114H Recombinant Human ERBB3 Protein, ECD, Tag Free, Biotinylated CHO Tag Free ECD
Human ERBB3-858H Recombinant Human ERBB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Erbb3-470M Active Recombinant Mouse V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Fc-tagged Mammalian cells Fc
Mouse ERBB3-38M Recombinant Mouse ERBB3 Protein, His-tagged Insect Cell His
Mouse Erbb3-2515M Recombinant Mouse Erbb3 protein(Met1-His641), His-tagged HEK293 C-His Met1-His641
Mouse ERBB3-1765MCL Recombinant Mouse ERBB3 cell lysate Human Cell N/A
Mouse Erbb3-43M Recombinant Mouse Erbb3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Erbb3-2515MAF555 Recombinant Mouse Erbb3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 633
Mouse Erbb3-2515MAF647 Recombinant Mouse Erbb3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 633
Mouse Erbb3-43M-B Recombinant Mouse Erbb3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Erbb3-384M Recombinant Mouse Erbb3 Protein, His-tagged E.coli His Leu707~Thr964
Mouse Erbb3-2515MAF488 Recombinant Mouse Erbb3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 633
Mouse Erbb3-970M Recombinant Mouse Erbb3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ErbB3-1411M Active Recombinant Mouse ErbB3 protein, His-tagged HEK293 His Ser20-His641
Mouse Erbb3-7201M Recombinant Mouse Erbb3 Protein, His-tagged Insect Cell His 20-641
Mouse Erbb3-2515MF Recombinant Mouse Erbb3 Protein, His-tagged, FITC conjugated HEK293 His 633
Rat Erbb3-7437R Recombinant Rat Erbb3 protein(Met1-His641), His-tagged HEK293 C-His Met1-His641
Rat ERBB3-2133R Recombinant Rat ERBB3 Protein Mammalian Cell His
Rat Erbb3-7436R Active Recombinant Rat Erbb3 protein, hFc-tagged HEK293 hFc Met1-His641
Rat ERBB3-1415RCL Recombinant Rat ERBB3 cell lysate Human Cell N/A
Rat Erbb3-7436RAF488 Recombinant Rat Erbb3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 863
Rat Erbb3-7436RAF555 Recombinant Rat Erbb3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 863
Rat ERBB3-1790R Recombinant Rat ERBB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Erbb3-7437RAF647 Recombinant Rat Erbb3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 633
Rat Erbb3-7437RAF488 Recombinant Rat Erbb3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 633
Rat Erbb3-7437RAF555 Recombinant Rat Erbb3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 633
Rat ERBB3-1790R-B Recombinant Rat ERBB3 Protein Pre-coupled Magnetic Beads HEK293
Rat Erbb3-7436RF Recombinant Rat Erbb3 Protein, Fc-tagged, FITC conjugated HEK293 Fc 863
Rat Erbb3-7437RF Recombinant Rat Erbb3 Protein, His-tagged, FITC conjugated HEK293 His 633
Rat Erbb3-7436RAF647 Recombinant Rat Erbb3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 863
Monkey ERBB3-1180RAF647 Active Recombinant Monkey ERBB3 Protein, Alexa Fluor 647 conjugated HEK293 LEVLFQ 631
Monkey ERBB3-1180RAF555 Active Recombinant Monkey ERBB3 Protein, Alexa Fluor 555 conjugated HEK293 LEVLFQ 631
Monkey ERBB3-1178RAF555 Active Recombinant Monkey ERBB3 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 865
Monkey ERBB3-1178RAF488 Active Recombinant Monkey ERBB3 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 865
Monkey ERBB3-1179RAF555 Active Recombinant Monkey ERBB3 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 635
Monkey ERBB3-1179RAF488 Active Recombinant Monkey ERBB3 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 635
Monkey ERBB3-1178RAF647 Active Recombinant Monkey ERBB3 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 865
Monkey ERBB3-1180RAF488 Active Recombinant Monkey ERBB3 Protein, Alexa Fluor 488 conjugated HEK293 LEVLFQ 631
Monkey ERBB3-1179RAF647 Active Recombinant Monkey ERBB3 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 635
Monkey ERBB3-1178RF Active Recombinant Monkey ERBB3 Protein, Fc-tagged, FITC conjugated HEK293 Fc 865
Monkey ERBB3-1179RF Active Recombinant Monkey ERBB3 Protein, His-tagged, FITC conjugated HEK293 His 635
Monkey ERBB3-1180RF Active Recombinant Monkey ERBB3 Protein, FITC conjugated HEK293 LEVLFQ 631
Rhesus ERBB3-1178R Active Recombinant Rhesus ERBB3 protein, hFc-tagged HEK293 hFc Met1-Thr643
Rhesus ERBB3-1179R Active Recombinant Rhesus ERBB3 protein(Met1-Thr643), His-tagged HEK293 C-His Met1-Thr643
Rhesus Macaque ERBB3-1180R Active Recombinant Rhesus ERBB3 Protein HEK293 N/A
Rhesus Macaque ERBB3-1721RCL Recombinant Rhesus ERBB3 cell lysate Human Cell N/A
Chicken ERBB3-3461C Recombinant Chicken ERBB3 Mammalian Cell His
  • Background
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  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
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ERBB3-7.jpg

Fig1. Schematic representation of the structural changes and activation of ErbB/HER receptors.

What is ERBB3 protein?

ERBB3 (erb-b2 receptor tyrosine kinase 3) is a protein coding gene which situated on the long arm of chromosome 12 at locus 12q13. ERBB3, also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but no active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. The ERBB3 protein is consisted of 1342 amino acids and its molecular mass is approximately 148 kDa.

What is the function of ERBB3 protein?

The main function of ERBB3 is to promote cell growth, survival, and differentiation through the activation of various intracellular signaling cascades. Upon binding of ligands such as heregulins (HRG), neuregulins (NRG), and other EGF family members, ERBB3 forms heterodimers with ERBB2 or other EGFR family members. This interaction leads to the activation of several downstream signaling pathways, including the PI3K-AKT and MAPK-ERK pathways. And it is involved in the regulation of myeloid cell differentiation.

ERBB3 related Signaling pathways

Some of the major signaling pathways associated with ERBB3 include: PI3K-AKT pathway, MAPK pathway. ERBB3 can activate the Janus kinases (JAKs) and subsequent signaling through the signal transducer and activator of transcription (STAT) proteins. ERBB3 can also form heterodimers with other ErbB family members such as ERBB1 (EGFR), ERBB2 (HER2), and ERBB4 (HER4) to activate more downstream signaling pathways.

ERBB3 Related Diseases

Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. Additionally, ERBB3 has been implicated in the regulation of neuronal and cardiac development. What's more, Lethal congenital contractural syndrome type 2 (LCCS2) is caused by a mutation in ERBB3 (Her3)that affect the function of the phosphatidylinositol-3-kinase /Akt pathway. A germline ERBB3 variant is also a candidate for predisposition to erythroid MDS/erythroleukemia. Another report found that dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans.

Bioapplications of ERBB3

Drug development targeting ERBB3 has become an important therapeutic strategy. For example, Trastuzumab (Herceptin), a monoclonal antibody drug that targets ERBB3, has been widely used in the treatment of HER2-positive breast cancer. In addition, the expression level of ERBB3 can be used as an important indicator for tumor diagnosis and prognosis evaluation. Manipulating ERBB3 signaling pathways can enhance or inhibit stem cell differentiation, which has applications in regenerative medicine and disease modeling.

High Purity

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ERBB3-2.jpg

Fig2. ELISA (ERBB3-084H)

Case Study 1: Yanyan Liu, 2023

ERBB3-3.jpg

Fig1. ROC analysis for the ability of ERBB3 to diagnose individuals with high LNM potentials of THCA. The expression level of ERBB3 has been examined in relation to different N stages.

Case Study 2: Tiia J Honkanen, 2023

ERBB3-4.jpg

Fig2. HER3 expression by western blot in H2228, H3122, and DFCI032 cell lines.

ERBB3 involved in several pathways and played different roles in them. We selected most pathways ERBB3 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ERBB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayRPS6KB2;BADB;ERBB2;CAMK2B;RAF1;CAMK2G1;GRB2B;PRKCG;ELK1
Calcium signaling pathwayADRa1A;CHRM1;PRKCA;CHRM3;SPHK2;ADRB3A;PLCB2;GNA11B;SLC8A1
EndocytosisSMAD3A;MHC1UEA;CHMP5B;ARRB2;VPS28;VPS25;VPS35;CXCR4B;CLTCB
Proteoglycans in cancerTRP53;MAPK1;MAP2K1;PDPK1;PXN;PIK3R2;ITPR3;MAPK13;RRAS
MicroRNAs in cancerMET;Casp3;ST14;TRIM71;RAF1;VIM;PIK3R2;IRS1;MDM4

ERBB3 has several biochemical functions, for example, ATP binding, growth factor binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ERBB3 itself. We selected most functions ERBB3 had, and list some proteins which have the same functions with ERBB3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingTSSK4;PTK7A;PRKACBB;TEX14;MYH9;NLRP4E;SMC5;ACSS1;BCS1L
growth factor bindingRPL37;A2M;NKD2;TEK;LIFR;ACVR2A;FGFBP2;HTRA1B;FLT4
identical protein bindingNOD1;DNM1L;RIPK1;RB1;SETX;MICU1;THBS1;TTC32;HCFC1
protein bindingPPFIA1;C1orf216;MAP4K5;MLF2;FAM46A;CNOT7;RRP7A;EIF2B1;GNE
protein heterodimerization activitySYT14;DMBX1;APOA2;NFYB;IL12A;TAL1;PANX2;TLX1;ATF1
protein homodimerization activitySIAH1A;CHMP4A;PVRL1B;PDGFA;SYT10;BHLHE40;DPP4;GDNF;ACTN1
protein tyrosine kinase activator activityAFAP1L2;GHRL;Cd24a;ABI1A;NRG1;ABI1;CD24;ABI1B;ABI3A
NOT protein tyrosine kinase activityERBB3;RYK;KLHL8;TWF1
transmembrane signaling receptor activityTNFRSF10C;IGSF6;GLP1R;CLEC2H;CD3D;LEPR;GPR113;TNFRSF8;OR4F29

ERBB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ERBB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ERBB3.

ERBB2

Research Area

Related articles

Huang, Z; Choi, BK; et al. The E3 ubiquitin ligase NEDD4 negatively regulates HER3/ErbB3 level and signaling. ONCOGENE 34:1105-1115(2015).
Nevoltris, D; Lombard, B; et al. Conformational Nanobodies Reveal Tethered Epidermal Growth Factor Receptor Involved in EGFR/ErbB2 Predimers. ACS NANO 9:1388-1399(2015).
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Q&As (5)

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What are the potential side effects of targeting ERBB3 in cancer therapy? 03/08/2023

Potential side effects may include skin rash, diarrhea, and cardiovascular issues, as seen with other drugs targeting the EGFR family.

How does ERBB3 contribute to resistance to certain cancer therapies? 01/29/2023

ERBB3 activation has been associated with resistance to some targeted therapies, such as EGFR inhibitors, making it a challenging target in cancer treatment.

How does ERBB3 interact with other receptors in the EGFR family? 11/07/2022

ERBB3 can form heterodimers with other EGFR family members, such as EGFR and HER2, leading to the activation of downstream signaling pathways.

Can ERBB3 be used as a biomarker for prognosis in cancer patients? 10/26/2022

Yes, elevated ERBB3 expression has been linked to poor prognosis in certain cancers, serving as a potential biomarker for patient outcomes.

In which types of cancers is ERBB3 commonly overexpressed? 10/19/2020

ERBB3 overexpression is frequently observed in breast, ovarian, and gastric cancers, among others.

Customer Reviews (3)

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10/28/2021

    Their expert team has been instrumental in addressing any challenges or concerns I have encountered during my experiments.

    08/11/2021

      Their prompt and comprehensive assistance has proven invaluable in overcoming obstacles and optimizing my experimental protocols.

      03/03/2020

        The ERBB3 protein boasts remarkable stability, allowing for extended storage without compromising its integrity or performance.

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