|Official Full Name||ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)|
|Background||ErbB3 is a member of the EGFR/erbB receptor tyrosine kinase family. ErbB3 lacks intrinsic kinase activity due to an amino acid substitution within the ATP binding site. Upon heterodimerization with the other erbB family members, erbB3 becomes phosphorylated at multiple tyrosine residues that represent docking sites for downstream signaling proteins, e.g. PI3K, grb7 and shc. The erbB3 cytoplasmic domain contains 6 docking sites for PI3K. Thus, erbB3 is a potent activator of the PI3K/PKB signaling pathway.|
|Synonyms||ERBB3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); LCCS2, lethal congenital contracture syndrome 2; receptor tyrosine-protein kinase erbB-3; HER3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; MGC88033;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
erbb3 involved in several pathways and played different roles in them. We selected most pathways erbb3 participated on our site, such as ErbB signaling pathway, Calcium signaling pathway, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with erbb3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|ErbB signaling pathway||ERBB4A; PIK3R3B; HRASB; NRG2; RAF1A; AKT2; PRKCA; GRB2A; AKT3A; MAP2K7|
|Calcium signaling pathway||PDE1A; PPIF; GRIN1A; ITPKB; P2RX3B; PDE1C; SPHK1; PPP3CCA; PRKACAB; HTR2C|
|Endocytosis||IL2RG; ARRB1; CYTH2; ARF5; HSPA1B; PML; CHMP2BB; ARPC5A; KIF5C; ARR3B|
|Proteoglycans in cancer||WNT2B; IL12B; ITGB5; HRAS; Casp3; KRAS; NRAS; ERBB3; CAMK2G; SDC2|
|MicroRNAs in cancer||TIMP3; TPM1; SOS1; KRAS; PDCD4; NOTCH4; MET; IRS2; ATM; GLS|
erbb3 has several biochemical functions, for example, ATP binding, growth factor binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by erbb3 itself. We selected most functions erbb3 had, and list some proteins which have the same functions with erbb3. You can find most of the proteins on our site.
|ATP binding||ACTB2; KLHL8; CTPS2; CDK19; HK3; LARS2; MCM6; TK2; TRIT1; PHKG2|
|growth factor binding||LIFR; NKD2; IGFBP2B; TEK; KDR; FLT4; ACVR2B; GHRHR; REG3B; LTBP2|
|identical protein binding||CLDN2; BAX; HSP90AA1; SOD2; DCP1A; SERPINA1A; PVRL2; COL1A2; RABAC1; PRMT1|
|protein binding||SMARCA4; KL; SOX13; KBTBD7; STT3A; UBA5; GAN; ROPN1; ABCF1; PRKCE|
|protein heterodimerization activity||SLC51A; PIK3R1; MEF2C; DRD1; SYT14; NFE2L2A; SRY; CYBA; BCL2; GCLC|
|protein homodimerization activity||DARS2; PARK7; APOBEC3G; FOXP2; PRDM6; PEX11A; PDCD10; TFRC; SPPL3; ENG|
|protein tyrosine kinase activator activity||AFAP1L2; NRG1; ABI1; ABI3A; GHRL; ABI1A; PAK2; ERBB3; CD24; GAS6|
|NOT protein tyrosine kinase activity||ERBB3; TWF1; RYK; KLHL8|
|transmembrane signaling receptor activity||LGR6; GHRHRA; CLDN4; CLEC4A; SELE; TLR7; TNFRSF11A; CELSR3; TLR3; CD5|
erbb3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with erbb3 here. Most of them are supplied by our site. Hope this information will be useful for your research of erbb3.