Recombinant Human ERBB3 Protein, His-Avi-tagged, Biotinylated
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|Product Overview :||Biotinylated Human ErbB3, His,Avitag is expressed from human 293 cells (HEK293). It contains AA Ser 20 - Thr 643 (Accession # P21860-1).|
|Description :||ErbB3,also known as Her3 (human epidermal growth factor receptor 3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain. It therefore can bind the ligand but cannot mediate the intracellular signal transduction through protein phosphorylation. However, it does form heterodimers with ErbB2 or other EGFR members responsible for tyrosine phosphorylation to give a receptor complex and initiate the related pathway, which lead to cell proliferation or differentiation. Overexpression of this protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.|
|Predicted N Terminal :||Ser 20|
|Form :||Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.|
|Molecular Mass :||The protein has a calculated MW of 72.4 kDa. The protein migrates as 95-105 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.|
|Protein length :||Ser 20 - Thr 643|
|Endotoxin :||Less than 1.0 EU per μg by the LAL method.|
|Purity :||>95% as determined by reduced SDS-PAGE.|
|Storage :||For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
|Reconstitution :||It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.|
Immobilized Biotinylated Human ErbB3, His, Avitag at 1 μg/mL (100 μL/well) on Streptavidin precoated (0.5 μg/well) plate, can bind Human NRG1 Beta 1, Fc Tag with a linear range of 0.5-8 ng/mL.
|Gene Name :||ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) [ Homo sapiens ]|
|Official Symbol :||ERBB3|
|Synonyms :||ERBB3; HER3; LCCS2; MDA-BF-1; MGC88033; c-erbB3; erbB3-S; p180-ErbB3; p45-sErbB3; p85-sErbB3|
|Gene ID :||2065|
|mRNA Refseq :||NM_001005915|
|Protein Refseq :||NP_001005915|
|UniProt ID :||P21860|
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