Recombinant Human V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), His-tagged

• Cat.No.: ERBB3-1216H
• Product Overview: Recombinant HumanTyrosine Kinase ERBB3 (extracellular domain) is a single, nonglycosylated, fusionpolypeptide chain containing Thyrodoxin Tag and His tag. The protein consistsof 190 amino acids (Met1- Cys190).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: ERBB3 is an enzyme that in humans is encoded by theERBB3 gene. This gene encodes a member of theepidermal growth factor receptor (EGFR) family of receptor tyrosine kinases.This membrane-bound protein has a neuregulin binding domain but not an activekinase domain. It therefore can bind this ligand but not convey the signalinto the cell through protein phosphorylation.
• Form: Liquid. Each mg ofprotein contains 1 mg aluminum hydroxide + 10 mM arginine + 10 mM sodiumchloride + 20 mM sodium phosphate buffer + 5 mM potassium phosphate.
• Molecular Weight: 34 kDa
• Concentration: 1 mg/ml
• Purity: > 95.0% asdetermined by RP-HPLC and SDS-PAGE analyses.
• Endotoxin Level: < 0.1 ng/ug ofERBB3.
• Biological Activity: Determined by itsability to postpone tumor emerge time of spontaneous breast cancer in FVB/Ntransgenic mice and inhibit the development of tumor and growth of in situ transplantedbreast cancer in FVB/N transgenic mice.
• Amino Acid Sequence: MRANDALQVLGLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM GNLEIVLTGH NADLSFLQWIREVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDTIDWRDIVRDR DAEIVVKDNG RSCPPCHEVC
• Storage: Storeat -20°C to -80°C with a carrier protein (0.1% HSA orBSA) as a stabilizer for long term storage. Please note that the addition ofany carrier protein into this product may produce unwanted endotoxin. Thisdepends upon the particular application employed. Avoid repeated freeze-thawcycles.
• OfficialSymbol: ERBB3

Gene Information

• Gene Name: ERBB3 v-erb-b2 erythroblasticleukemia viral oncogene homolog 3 (avian) [ Homo sapiens ]
• Synonyms: ERBB3; v-erb-b2erythroblastic leukemia viral oncogene homolog 3 (avian); HER3; LCCS2;ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; MGC88033; c-erbB-3; p180-ErbB3;p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3;OTTHUMP00000243039; OTTHUMP00000243040; OTTHUMP00000243072;OTTHUMP00000243359; OTTHUMP00000243360; proto-oncogene-like protein c-ErbB-3;tyrosine kinase-type cell surface receptor HER3
• Gene ID: 2065
• mRNA Refseq: NM_001982
• Protein Refseq: NP_001973
• MIM: 190151
• UniProt ID: P21860
• Chromosome Location: 12q13
• Pathway: Calcium signalingpathway; Endocytosis; ErbB receptor signaling network; ErbB signalingpathway; ErbB2/ErbB3 signaling events; Heart Development; IL-6 SignalingPathway; a6b1 and a6b4 Integrin signaling
• Function: ATP binding; growthfactor binding; nucleotide binding; protein binding; proteinheterodimerization activity; protein tyrosine kinase activator activity; NOTprotein tyrosine kinase activity; receptor activity; receptor signalingprotein tyrosine kinase activity; transmembrane receptor protein tyrosinekinase activity; transmembrane signaling receptor activity