Recombinant Human ERBB3 Protein, His-tagged
Cat.No. : | ERBB3-02H |
Product Overview : | Recombinant Human ERBB3 Protein, fused to His-tag, was expressed in Insect cell. |
- Specification
- Gene Information
- Related Products
- Download
Description : | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. |
Source : | Insect cell |
Species : | Human |
Tag : | His |
Molecular Mass : | 42.5 kDa |
AA Sequence : | MLLVNQSHQGFNKEHTSKMVSAIVL YVLLAAAAHSAFAHHHHHHGESIEP LDPSEKANKVLARIFKETELRKLKV LGSGVFGTVHKGVWIPEGESIKIPV CIKVIEDKSGRQSFQAVTDHMLAIG SLDHAHIVRLLGLCPGSSLQLVTQY LPLGSLLDHVRQHRGALGPQLLLNW GVQIAKGMYYLEEHGMVHRNLAARN VLLKSPSQVQVADFGVADLLPPDDK QLLYSEAKTPIKWMALESIHFGKYT HQSDVWSYGVTVWELMTFGAEPYAG LRLAEVPDLLEKGGRLAQPQICTID VYMVMVKCWMIDENIRPTFKELANE FTRMARDPPRYLVIKRESGPGIAPG PEPHGLTNKKLEEVELEPELDLDLD LEAEED |
Gene Name : | ERBB3 erb-b2 receptor tyrosine kinase 3 [ Homo sapiens (human) ] |
Official Symbol : | ERBB3 |
Synonyms : | HER3; FERLK; LCCS2; VSCN1; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3 |
Gene ID : | 2065 |
mRNA Refseq : | NM_001982.4 |
Protein Refseq : | NP_001973.2 |
MIM : | 190151 |
UniProt ID : | P21860 |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (0)
Ask a questionAsk a Question for All HER3 Products
Required fields are marked with *
My Review for All HER3 Products
Required fields are marked with *
0
Inquiry Basket