ESRRA
-
Official Full Name
estrogen-related receptor alpha -
Overview
The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013] -
Synonyms
ESRRA;estrogen-related receptor alpha;ERR1;ERRa;ESRL1;NR3B1;ERRalpha;steroid hormone receptor ERR1;ERR-alpha;estrogen receptor-like 1;estrogen-related nuclear receptor alpha;nuclear receptor subfamily 3 group B member 1
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mouse
- Mammalian Cells
- Sf9 Cells
- Yeast
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
ESRRA involved in several pathways and played different roles in them. We selected most pathways ESRRA participated on our site, such as Energy Metabolism,Fatty acid, triacylglycerol, and ketone body metabolism,Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with ESRRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mitochondrial Gene Expression | TFB2M,POLRMT,TFB1M,MTERFD1,PPRC1,PPARGC1B |
| Energy Metabolism | PPARGC1B,UCP2,MYBBP1A,MEF2B,UCP3,TFB1M,GABPA,TFB2M |
| Generic Transcription Pathway | ZNF544,ZNF43,ZNF443,ESRRGA,NR2E3,ZNF3,ZNF484,ZNF192,ZIK1,ZNF671 |
| Metabolism of lipids and lipoproteins | ALOX5B.2,MED19,MED8,FABP12,OSBP,BRSK2,MED18,ARSI,ACOT2,Agmo |
| Gene Expression | ZKSCAN3,ZNF549,BAZ2A,TP53RK,SKI,ZNF223,ZFP37,SSRP1,ZFP28,POLR3C |
| Mitochondrial biogenesis | POLG2,PPRC1,MTERF,C10orf2,POLRMT,PPARGC1B,TFB1M,TFB2M,GABPA,GABPB1 |
| Fatty acid, triacylglycerol, and ketone body metabolism | APOA5,MED25,CDK19,ECI1,MED15,MMAA,CDK8,GRHL1,MTF1,ACOT6 |
| Metabolism | SPRB,LPA,NUDT5,NUDT18,FAM213B,MTF1,ALDH9A1A.2,MED22,PROZA,PPM1K |
Protein Function
ESRRA has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ESRRA itself. We selected most functions ESRRA had, and list some proteins which have the same functions with ESRRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CCNK,NXT2,TNFAIP8L2,DGAT1,FAM129A,CDKN2A,CDH5,LRRC75A-AS1,NAPRT1,HNRNPK |
| sequence-specific DNA binding | DLX6A,GRHL2A,HOXB9A,HNF1B,DMRT3,RREB1,NEUROG2,HOXD3A,DLX4A,ENG2A |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | NOBOX,SALL1,GMEB2,MLXIPL,PITX3,NFATC4,ISL1,ZKSCAN3,MYOG,ONECUT2 |
| protein domain specific binding | NEDD4,DBNL,TWIST1,CALM1,STAMBP,CEP68,IGBP1,CAPG,ANGEL1,NEFL |
| steroid hormone receptor activity | NR2F5,NR0B1,OLFR78,NR2E3,RORCB,RXRG,RXRB,NR1D2,RARGB,RXRGB |
| DNA binding | ZNF19,POLR2J2,DTD1,NR4A1,RCAN1,SAFB2,SSH2B,ZNF280C,ZNF471,SMARCAD1 |
| zinc ion binding | BTR22,LHX2A,CAR13,TRIM6,ZDHHC23B,PGLYRP1,CPD,RNF19A,LHX8,SNAI1A |
| steroid binding | Ar,PGRMC1,PGR,ESRRB,CYP21A1,ESRRG,SERPINA6,FAM84B,ESR2,UGT1A1 |
| RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding | RORC,NR4A2,ESR2,NR1I3,NR5A5,STAT3,NR2F6A,NR5A1,VDRA,PPARAB |
Interacting Protein
ESRRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ESRRA here. Most of them are supplied by our site. Hope this information will be useful for your research of ESRRA.
TRRAP;FUS;ADH5;ATXN1;MAP2K5;q81ye8_bacan;recN;PIAS4;PNRC2;NXF1;mdm2_human_probe;pdk4_human_gene;Esrrb;KAT2A;KAT8
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References
- Harada, K; Kakuda, Y; et al. Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. JOURNAL OF CLINICAL PATHOLOGY 67:396-402(2014).
- Esch, AM; Thompson, NE; et al. Production and characterization of monoclonal antibodies to estrogen-related receptor alpha (ERR alpha) and use in immunoaffinity chromatography. PROTEIN EXPRESSION AND PURIFICATION 84:47-58(2012).
