|Official Full Name||fibulin 5|
|Background||The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).|
|Synonyms||FBLN5; fibulin 5|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
fbln5 involved in several pathways and played different roles in them. We selected most pathways fbln5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with fbln5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
fbln5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by fbln5 itself. We selected most functions fbln5 had, and list some proteins which have the same functions with fbln5. You can find most of the proteins on our site.
fbln5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with fbln5 here. Most of them are supplied by our site. Hope this information will be useful for your research of fbln5.