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FBLN5

  • Official Full Name

    fibulin 5

  • Overview

    The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
  • Synonyms

    FBLN5; fibulin 5;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • HA
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FBLN5-568H Active Recombinant Human FBLN5 Protein, His-tagged CHO His Gln24-Phe448
Human FBLN5-7898H Recombinant Human FBLN5 protein, His & T7-tagged E.coli His/T7 Leu99~Cys205 (Accession # Q9UBX5)
Human FBLN5-3876H Recombinant Human FBLN5 Protein, GST-tagged Wheat Germ GST
Human FBLN5-6317HCL Recombinant Human FBLN5 293 Cell Lysate HEK293 N/A
Human FBLN5-893H-B Recombinant Human FBLN5 Protein Pre-coupled Magnetic Beads HEK293
Human FBLN5-301573H Recombinant Human FBLN5 protein, GST-tagged E.coli GST Gly186-Phe448
Human FBLN5-3426H Recombinant Human FBLN5 Protein (Leu99-Cys205), N-His tagged E.coli N-His Leu99-Cys205
Human FBLN5-588HFL Recombinant Full Length Human FBLN5 Protein, C-Flag-tagged Mammalian cells Flag
Human FBLN5-3882H Active Recombinant Human Fibulin 5 Protein, HA-tagged HEK293 HA 24-448
Human FBLN5-4894HF Recombinant Full Length Human FBLN5 Protein, GST-tagged In Vitro Cell Free System GST 448 amino acids
Human FBLN5-893H Recombinant Human FBLN5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FBLN5-5703M Recombinant Mouse FBLN5 Protein Mammalian Cell His
Mouse Fbln5-7899M Recombinant Mouse Fbln5 protein, His-tagged E.coli His Ile327~Phe448 (Accession # Q9WVH9)
Mouse FBLN5-3133M-B Recombinant Mouse FBLN5 Protein Pre-coupled Magnetic Beads HEK293
Mouse FBLN5-3133M Recombinant Mouse FBLN5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Fbln5-2959M Recombinant Mouse Fbln5 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat FBLN5-2282R Recombinant Rat FBLN5 Protein Mammalian Cell His
Rat Fbln5-7900R Recombinant Rat Fbln5 protein, His-tagged E.coli His Tyr277~Phe448 (Accession # Q9WVH8)
Rat FBLN5-1939R-B Recombinant Rat FBLN5 Protein Pre-coupled Magnetic Beads HEK293
Rat FBLN5-1939R Recombinant Rat FBLN5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque FBLN5-1650R Recombinant Rhesus monkey FBLN5 Protein, His-tagged Mammalian Cell His
Rhesus Macaque FBLN5-1474R-B Recombinant Rhesus Macaque FBLN5 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque FBLN5-1474R Recombinant Rhesus Macaque FBLN5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish FBLN5-1504Z Recombinant Zebrafish FBLN5 Mammalian Cell His
Chicken FBLN5-4870C Recombinant Chicken FBLN5 Mammalian Cell His
  • FBLN5 Related Research Area

FBLN5 involved in several pathways and played different roles in them. We selected most pathways FBLN5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBLN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

FBLN5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by FBLN5 itself. We selected most functions FBLN5 had, and list some proteins which have the same functions with FBLN5. You can find most of the proteins on our site.

Function Related Protein

FBLN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBLN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBLN5.

  • Q&As
  • Reviews

Q&As (6)

Ask a question
Is there a relationship between the structure and function of FBLN5? 06/27/2023

The structure of FBLN5 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.

Does lack or overexpression of FBLN5 make a difference? 06/25/2022

FBLN5 deficiency may lead to uncontrolled fibrinogen activity, resulting in premature degradation of fibrin, affecting the process of blood coagulation and hemostasis. However, the overexpression of FBLN5 may over-inhibit the activity of plasminogen, resulting in abnormal blood coagulation and hemostasis.

What is the main function of FBLN5 in the blood? 06/15/2022

The main function of FBLN5 in the blood is to bind and regulate the action of fibrinogen, prevent excessive degradation of fibrin in the blood, maintain blood flow and normal clotting process.

What are the therapeutic strategies for FBLN5? 12/26/2021

Therapeutic strategies for FBLN5 may include supplementing or inhibiting its expression and regulating its interaction with other proteins. These methods may have potential application value in the treatment of coagulation disorders and thrombosis.

Does FBLN5 interact with other proteins? 12/25/2021

It can interact with a variety of other proteins, including fibrinogen and plasminogen. These interactions allow it to regulate the metabolism of fibrin and the blood clotting process.

Does FBLN5 play a role in cardiovascular disease? 01/20/2021

In cardiovascular disease, FBLN5 may influence disease development and prognosis by regulating fibrin metabolism and coagulation processes. It could be a potential target for the treatment of cardiovascular disease.

Customer Reviews (3)

Write a review
Reviews
07/11/2023

    FBLN5 has good stability in different environments and is not easy to degrade.

    05/29/2023

      FBLN5 is accurately positioned in the bands in Western blot, showing good specificity.

      09/23/2020

        Good stability in vivo.

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