FBLN5
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Official Full Name
fibulin 5
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Overview
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). -
Synonyms
FBLN5; fibulin 5;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- CHO
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- HA
- His
- Fc
- Avi
- T7
- Myc
- DDK
- Non
- Other Resource
FBLN5 involved in several pathways and played different roles in them. We selected most pathways FBLN5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with FBLN5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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FBLN5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by FBLN5 itself. We selected most functions FBLN5 had, and list some proteins which have the same functions with FBLN5. You can find most of the proteins on our site.
| Function | Related Protein |
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FBLN5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FBLN5 here. Most of them are supplied by our site. Hope this information will be useful for your research of FBLN5.
Research Area
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewFBLN5 has good stability in different environments and is not easy to degrade.
FBLN5 is accurately positioned in the bands in Western blot, showing good specificity.
Good stability in vivo.
Q&As (6)
Ask a questionThe structure of FBLN5 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.
FBLN5 deficiency may lead to uncontrolled fibrinogen activity, resulting in premature degradation of fibrin, affecting the process of blood coagulation and hemostasis. However, the overexpression of FBLN5 may over-inhibit the activity of plasminogen, resulting in abnormal blood coagulation and hemostasis.
The main function of FBLN5 in the blood is to bind and regulate the action of fibrinogen, prevent excessive degradation of fibrin in the blood, maintain blood flow and normal clotting process.
Therapeutic strategies for FBLN5 may include supplementing or inhibiting its expression and regulating its interaction with other proteins. These methods may have potential application value in the treatment of coagulation disorders and thrombosis.
It can interact with a variety of other proteins, including fibrinogen and plasminogen. These interactions allow it to regulate the metabolism of fibrin and the blood clotting process.
In cardiovascular disease, FBLN5 may influence disease development and prognosis by regulating fibrin metabolism and coagulation processes. It could be a potential target for the treatment of cardiovascular disease.
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