Recombinant Human FBLN5 Protein, GST-tagged

• Cat.No.: FBLN5-3876H
• Product Overview: Human FBLN5 full-length ORF (BAG52073.1, 1 a.a. - 448 a.a.) recombinant protein with GST tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 76.6 kDa
• AA Sequence: MPGIKRILTVTILALCLPSPGNAQA QCTNGFDLDRQSGQCLDIDECRTIP EACRGDMMCVNQNGGYLCIPRTNPV YRGPYSNPYSTPYSGPYPAAAPPLS APNYPTISRPLICRFGYQMDESNQC VDVDECATDSHQCNPTQICINTEGG YTCSCTDGYWLLEGQCLDIDECRYG YCQQLCANVPGSYSCTCNPGFTLNE DGRSCQDVNECATENPCVQTCVNTY GSFICRCDPGYELEEDGVHCSDMDE CSFSEFLCQHECVNQPGTYFCSCPP GYILLDDNRSCQDINECEHRNHTCN LQQTCYNLQGGFKCIDPIRCEEPYL RISDNRCMCPAENPGCRDQPFTILY RDMDVVSGRSVPADIFQMQATTRYP GAYYIFQIKSGNEGREFYMRQTGPI SATLVMTRPIKGPREIQLDLEMITV NTVINFRGSSVIRLRIYVSQYPF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: FBLN5 fibulin 5 [ Homo sapiens ]
• Official Symbol: FBLN5
• Synonyms: FBLN5; fibulin 5; Fibulin 5; Developmental Arteries And Neural Crest EGF-Like Protein; Urine P50 Protein; FIBL-5; DANCE; UP50; Testis Tissue Sperm-Binding Protein Li 75n; Fibulin-5; ARCL1A; HNARMD; ADCL2; ARMD3; EVEC; fibulin-5; developmental arteries and neural crest EGF-like protein; testis tissue sperm-binding protein Li 75n; urine p50 protein
• Gene ID: 10516
• mRNA Refseq: NM_006329
• Protein Refseq: NP_006320
• MIM: 604580
• UniProt ID: Q9UBX5