Recombinant Human FBLN5 Protein (Leu99-Cys205), N-His tagged

• Cat.No.: FBLN5-3426H
• Product Overview: Recombinant human FBLN5 (Leu99-Cys205) protein fused with the N-His tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
• Source: E. coli
• Species: Human
• Tag: N-His
• Molecular Mass: 14.15 kDa
• Protein Length: Leu99-Cys205
• Purity: >90 % as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02 % NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: FBLN5 fibulin 5 [ Homo sapiens (human) ]
• Official Symbol: FBLN5
• Synonyms: FBLN5; fibulin 5; EVEC; UP50; ADCL2; ARMD3; CMT1H; DANCE; ARCL1A; FIBL-5; HNARMD; fibulin-5; developmental arteries and neural crest EGF-like protein; embryonic vascular EGF-like repeat-containing protein; testis tissue sperm-binding protein Li 75n; urine p50 protein
• Gene ID: 10516
• mRNA Refseq: NM_006329
• Protein Refseq: NP_006320
• MIM: 604580
• UniProt ID: Q9UBX5