Recombinant Full Length Human FBLN5 Protein, C-Flag-tagged

• Cat.No.: FBLN5-588HFL
• Product Overview: Recombinant Full Length Human FBLN5 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 47.8 kDa
• AA Sequence: MPGIKRILTVTILALCLPSPGNAQA QCTNGFDLDRQSGQCLDIDECRTIP EACRGDMMCVNQNGGYLCIP RTNPVYRGPYSNPYSTPYSGPYPAA APPLSAPNYPTISRPLICRFGYQMD ESNQCVDVDECATDSHQCNP TQICINTEGGYTCSCTDGYWLLEGQ CLDIDECRYGYCQQLCANVPGSYSC TCNPGFTLNEDGRSCQDVNE CATENPCVQTCVNTYGSFICRCDPG YELEEDGVHCSDMDECSFSEFLCQH ECVNQPGTYFCSCPPGYILL DDNRSCQDINECEHRNHTCNLQQTC YNLQGGFKCIDPIRCEEPYLRISDN RCMCPAENPGCRDQPFTILY RDMDVVSGRSVPADIFQMQATTRYP GAYYIFQIKSGNEGREFYMRQTGPI SATLVMTRPIKGPREIQLDL
  EMITVNTVINFRGSSVIRLRIYVSQ YPFTRTRPLEQKLISEEDLAANDIL DYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Secreted Protein

Gene Information

• Gene Name: FBLN5 fibulin 5 [ Homo sapiens (human) ]
• Official Symbol: FBLN5
• Synonyms: EVEC; UP50; ADCL2; ARMD3; CMT1H; DANCE; ARCL1A; FIBL-5; HNARMD
• Gene ID: 10516
• mRNA Refseq: NM_006329.4
• Protein Refseq: NP_006320.2
• MIM: 604580
• UniProt ID: Q9UBX5