Creative BioMart to Present at BPS 2025 Annual Meeting | February 15-19, 2025

FCN2

  • Official Full Name

    ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)

  • Overview

    The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • Synonyms

    FCN2; ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); ficolin-2; collagen/fibrinogen domain containing protein 2; EBP 37; FCNL; ficolin B; ficolin 2; hucolin; L ficolin; P35; serum lectin p35; 37 kDa elastin-binding protein; Ficolin beta; OTTHUMP00000022518; RP11-263F14.2; L-ficolin; ficolin-B; ficolin-beta; collagen/fibrinogen domain-containing protein 2; EBP-37;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • GST
  • His
  • Fc
  • Avi
  • Myc
  • DDK
  • Non
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

FCN2 involved in several pathways and played different roles in them. We selected most pathways FCN2 participated on our site, such as Complement cascade, Creation of C4 and C2 activators, Ficolins bind to repetitive carbohydrate structures on the target cell surface, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Complement cascadeIgG3;CFHL1;FCN2;CRP;CFD;FCN3;IGKC;CFHL3;HBL3
Creation of C4 and C2 activatorsFCN3;IgG3;IGKV1-5;HBL3;FCN1;IGLC2;MASP2;FCN2;CRP
Ficolins bind to repetitive carbohydrate structures on the target cell surfaceFCN2;MASP2;FCN3;FCN1
Immune SystemLAT2;WSB1;CD200;IRF2;IFI6;LILRA2;CLEC4D;TPP2;MYO1C
Initial triggering of complementBFB;CFD;HBL3;CRP;FCN2;MASP2;FCN3;FCN1;GZMM
Innate Immune SystemRCA2.1;LGALS3;SUGT1;FAM49BA;NLRP3;CD300LB;Txn1;ABI1B;BTR18
Lectin pathway of complement activationHBL3;FCN3;FCN1;FCN2

FCN2 has several biochemical functions, for example, antigen binding, calcium-dependent protein binding, mannan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FCN2 itself. We selected most functions FCN2 had, and list some proteins which have the same functions with FCN2. You can find most of the proteins on our site.

Function Related Protein
antigen bindingIGHM;IGLL1;LCK;SLAMF1;Ighg2b;IgG3;Ighg2a;IGKC;TOPORS
calcium-dependent protein bindingSEC31A;CD209A;CALM3;STMN2;CCDC167;FCN2;SLC9A1;ANXA3;SYT1
mannan bindingFCN2;REG4
protein bindingAP2A1;NECAB3;TEKT5;EOMESA;EHD2;MOB1A;ST6GAL1;Arid4b;CYBRD1
proteoglycan bindingCECR1;UBE4A;CTSB;CTSL1;CTSK;SLIT2;COL5A1;CTSS;THBS1

FCN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FCN2.

LRP1; CRP; q9wmx2-pro_0000037550

Research Area

Related articles

Metzger, ML; Michelfelder, I; et al. Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 179:256-264(2015).
Osthoff, M; Irungu, E; et al. Mannose-binding lectin and ficolin-2 do not influence humoral immune response to hepatitis B vaccine. VACCINE 32:4772-4777(2014).
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