Recombinant Human FGF19 Protein, His-tagged

• Cat.No.: FGF19-48H
• Product Overview: Recombinant Human FGF19 Protein (aa 25-216) is produced by HEK 293 cells expression system. This protein is fused with a His tag at the C-terminus.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Protein Length: aa 25-216
• Description: FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
• Form: Lyophilized from 0.2μm-filtered solution in 1x PBS.
• Molecular Mass: 22kDa (SDS-PAGE)
• Endotoxin: <0.06EU/μg purified protein (LAL test; Lonza).
• Purity: ≥90% (SDS-PAGE)
• Notes: Avoid freeze/thaw cycles.
• Stability: Stable for at least 1 year after receipt when stored at -20 centigrade.
  Working aliquots are stable for up to 3 months when stored at -20 centigrade.
• Storage: Short Term Storage at +4 centigrade.
  Long Term Storage at -20 centigrade.
• Reconstitution: 10µg vial: Reconstitute with 100 µl sterile water to a concentration of 0.1mg/ml.
  50µg vial: Reconstitute with 50 µl sterile water to a concentration of 1mg/ml.
  Add 1X PBS to the desired protein concentration.

Gene Information

• Gene Name: FGF19 fibroblast growth factor 19 [ Homo sapiens ]
• Official Symbol: FGF19
• Synonyms: FGF19; fibroblast growth factor 19; FGF-19
• Gene ID: 9965
• mRNA Refseq: NM_005117
• Protein Refseq: NP_005108
• MIM: 603891
• UniProt ID: O95750