|Product Overview :||Recombinant Human FGF19 Protein (aa 25-216) is produced by HEK 293 cells expression system. This protein is fused with a His tag at the C-terminus.|
|Description :||FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.|
|Form :||Lyophilized from 0.2μm-filtered solution in 1x PBS.|
|Molecular Mass :||22kDa (SDS-PAGE)|
|Protein length :||aa 25-216|
|Endotoxin :||<0.06EU/μg purified protein (LAL test; Lonza).|
|Purity :||≥90% (SDS-PAGE)|
|Notes :||Avoid freeze/thaw cycles.|
|Stability :||Stable for at least 1 year after receipt when stored at -20 centigrade.
Working aliquots are stable for up to 3 months when stored at -20 centigrade.
|Storage :||Short Term Storage at +4 centigrade.
Long Term Storage at -20 centigrade.
|Reconstitution :||10µg vial: Reconstitute with 100 µl sterile water to a concentration of 0.1mg/ml.
50µg vial: Reconstitute with 50 µl sterile water to a concentration of 1mg/ml.
Add 1X PBS to the desired protein concentration.
|Gene Name :||FGF19 fibroblast growth factor 19 [ Homo sapiens ]|
|Official Symbol :||FGF19|
|Synonyms :||FGF19; fibroblast growth factor 19; FGF-19;|
|Gene ID :||9965|
|mRNA Refseq :||NM_005117|
|Protein Refseq :||NP_005108|
|UniProt ID :||O95750|