Recombinant Human FGF19 Protein, His-tagged

Cat.No. : FGF19-48H
Product Overview : Recombinant Human FGF19 Protein (aa 25-216) is produced by HEK 293 cells expression system. This protein is fused with a His tag at the C-terminus.
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Description : FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
Source : HEK293
Species : Human
Tag : His
Form : Lyophilized from 0.2μm-filtered solution in 1x PBS.
Molecular Mass : 22kDa (SDS-PAGE)
Protein length : aa 25-216
Endotoxin : <0.06EU/μg purified protein (LAL test; Lonza).
Purity : ≥90% (SDS-PAGE)
Notes : Avoid freeze/thaw cycles.
Stability : Stable for at least 1 year after receipt when stored at -20 centigrade.
Working aliquots are stable for up to 3 months when stored at -20 centigrade.
Storage : Short Term Storage at +4 centigrade.
Long Term Storage at -20 centigrade.
Reconstitution : 10µg vial: Reconstitute with 100 µl sterile water to a concentration of 0.1mg/ml.
50µg vial: Reconstitute with 50 µl sterile water to a concentration of 1mg/ml.
Add 1X PBS to the desired protein concentration.
Gene Name : FGF19 fibroblast growth factor 19 [ Homo sapiens ]
Official Symbol : FGF19
Synonyms : FGF19; fibroblast growth factor 19; FGF-19;
Gene ID : 9965
mRNA Refseq : NM_005117
Protein Refseq : NP_005108
MIM : 603891
UniProt ID : O95750

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is FGF19 gene expression regulated, and what factors influence its secretion and activity in various tissues? 09/12/2021

FGF19 expression is regulated by bile acids and other factors. Its secretion and activity are influenced by nutrient availability, signaling pathways, and interactions with bile acid receptors.

Can you discuss the potential therapeutic applications of targeting FGF19 in metabolic disorders, and what challenges exist in developing such interventions? 05/20/2020

Targeting FGF19 holds therapeutic potential for metabolic disorders. Challenges include achieving tissue-specific effects and understanding the long-term consequences of manipulating FGF19 signaling.

Can you explain the role of FGF19 in the enterohepatic circulation of bile acids and its implications for metabolic health? 04/05/2019

FGF19 regulates bile acid synthesis in the liver and influences the enterohepatic circulation, impacting metabolic health by modulating lipid and glucose metabolism.

What is the role of FGF19 in the regulation of gut hormone secretion, and how does this contribute to its effects on metabolic processes? 02/02/2019

FGF19 influences gut hormone secretion, including the release of glucagon-like peptide-1 (GLP-1). This regulation contributes to its metabolic effects, such as enhanced insulin sensitivity and reduced food intake.

What is the significance of FGF19 in metabolic diseases, and how does dysregulation contribute to conditions like obesity and non-alcoholic fatty liver disease (NAFLD)? 12/29/2018

Dysregulation of FGF19 is implicated in metabolic diseases, including obesity and NAFLD. Altered FGF19 signaling may contribute to aberrant bile acid and lipid metabolism in these conditions.

Customer Reviews (3)

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Reviews
01/14/2022

    Top-notch protein quality! It's our go-to for reliable and reproducible results.

    09/08/2020

      This product simplifies our research. It's a reliable tool that we can count on.

      05/11/2018

        If you're in the lab, you need this product. It streamlines processes and is a lab necessity.

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