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Recombinant Rat Fgf19 protein, His-tagged

Cat.No. : Fgf19-1815R
Product Overview : Recombinant Rat Fgf19 aa. (Gly25~Lys218) fused with N-terminal His tag was produced in E. coli cells.
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  • Gene Information
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Description : Member of the fibroblast growth factor (FGF) family; implicated in activities including embryonic development, cell growth, morphogenesis, tissue growth, and tumor growth and invasion.
Source : E. coli
Species : Rat
Tag : His
Form : Freeze-dried powder
Molecular Mass : 24kDa as determined by SDS-PAGE reducing conditions.
Protein length : Gly25~Lys218
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Applications : SDS-PAGE; WB; ELISA; IP; CoIP; Reporter Assays; Purification; Amine Reactive Labeling.
Stability : The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Concentration : 200μg/mL
Storage buffer : PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
Reconstitution : Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Isoelectric Point : 6.6
Gene Name : Fgf19 fibroblast growth factor 19 [ Rattus norvegicus (Norway rat) ]
Official Symbol : Fgf19
Synonyms : Fgf19; fibroblast growth factor 19; Fgf15; fibroblast growth factor 19; fibroblast growth factor 15
Gene ID : 170582
mRNA Refseq : NM_130753.1
Protein Refseq : NP_570109.1
UniProt ID : Q8VI81

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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How is FGF19 gene expression regulated, and what factors influence its secretion and activity in various tissues? 09/12/2021

FGF19 expression is regulated by bile acids and other factors. Its secretion and activity are influenced by nutrient availability, signaling pathways, and interactions with bile acid receptors.

Can you discuss the potential therapeutic applications of targeting FGF19 in metabolic disorders, and what challenges exist in developing such interventions? 05/20/2020

Targeting FGF19 holds therapeutic potential for metabolic disorders. Challenges include achieving tissue-specific effects and understanding the long-term consequences of manipulating FGF19 signaling.

Can you explain the role of FGF19 in the enterohepatic circulation of bile acids and its implications for metabolic health? 04/05/2019

FGF19 regulates bile acid synthesis in the liver and influences the enterohepatic circulation, impacting metabolic health by modulating lipid and glucose metabolism.

What is the role of FGF19 in the regulation of gut hormone secretion, and how does this contribute to its effects on metabolic processes? 02/02/2019

FGF19 influences gut hormone secretion, including the release of glucagon-like peptide-1 (GLP-1). This regulation contributes to its metabolic effects, such as enhanced insulin sensitivity and reduced food intake.

What is the significance of FGF19 in metabolic diseases, and how does dysregulation contribute to conditions like obesity and non-alcoholic fatty liver disease (NAFLD)? 12/29/2018

Dysregulation of FGF19 is implicated in metabolic diseases, including obesity and NAFLD. Altered FGF19 signaling may contribute to aberrant bile acid and lipid metabolism in these conditions.

Customer Reviews (3)

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Reviews
01/14/2022

    Top-notch protein quality! It's our go-to for reliable and reproducible results.

    09/08/2020

      This product simplifies our research. It's a reliable tool that we can count on.

      05/11/2018

        If you're in the lab, you need this product. It streamlines processes and is a lab necessity.

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