Recombinant Human FGF19, FLAG-tagged

• Cat.No.: FGF19-251H
• Product Overview: Signal peptide and human FGF-19 (aa 1-216) are fused at the C-terminus to a FLAG-tag.

Specification

• Description: FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
• Source: HEK293 Cells
• Species: Human
• Tag: FLAG
• Form: Lyophilized from 0.2μm-filtered solution in PBS, pH 7.2.
• Molecular Mass: ~26kDa (SDS-PAGE)
• Purity: ≥90% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: FGF19 fibroblast growth factor 19 [ Homo sapiens ]
• Official Symbol: FGF19
• Synonyms: FGF19; fibroblast growth factor 19; FGF-19
• Gene ID: 9965
• mRNA Refseq: NM_005117
• Protein Refseq: NP_005108
• MIM: 603891
• UniProt ID: O95750
• Chromosome Location: 11q13.1
• Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR4 ligand binding and activation, organism-specific biosystem; FRS2-mediated cascade, organism-specific biosystem; IRS-mediated signalling, organism-specific biosystem; IRS-related events, organism-specific biosystem
• Function: fibroblast growth factor receptor binding; growth factor activity; protein binding; protein tyrosine kinase activity