Recombinant Human FGF19 Protein, Fc-tagged

• Cat.No.: FGF19-28824TH
• Product Overview: Recombinant Human FGF19(aa 1-216) fused with the C-terminus the Fc portion of human IgG1 was expressed in HEK 293 cells.

Specification

• Description: FGF-19 (Fibroblast growth factor 19) is involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. FGF-19 plays an important role in brain development during embryogenesis. FGF-19 binds only to FGF receptor 4 (FGFR4). Activity requires the presence of KLB.
• Source: HEK 293 cells
• Species: Human
• Tag: Fc
• Form: Lyophilized from 0.2μm-filtered solution in PBS, pH 7.2.
• Molecular Mass: ~50kDa (SDS-PAGE)
• Protein length: aa 1-216
• Endotoxin: <0.1EU/μg purified protein (LAL test; Lonza).
• Purity: ≥90% (SDS-PAGE)
• Stability: Stable for at least 6 months after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade.
• Storage: Short Term Storage +4 centigrade;
  Long Term Storage -20 centigrade;
  After reconstitution, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles.
• Reconstitution: Reconstitute in distilled water.

Gene Information

• Gene Name: FGF19 fibroblast growth factor 19 [ Homo sapiens ]
• Official Symbol: FGF19
• Synonyms: FGF19; fibroblast growth factor 19; FGF-19
• Gene ID: 9965
• mRNA Refseq: NM_005117
• Protein Refseq: NP_005108
• MIM: 603891
• UniProt ID: O95750