Recombinant Human FGF19 protein
Cat.No. : | FGF19-238H |
Product Overview : | Recombinant Human FGF19 protein was expressed in Escherichia coli. |
- Specification
- Gene Information
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Description : | Human FGF-19 is encoded by the FGF19 gene. FGF-19 belongs to the FGF-19 subfamily which has three members FGF-19, 21, 23. FGFs are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis. By contrast, the FGF-19 subfamily has recently been shown to function in an endocrine manner. Members of this subfamily have poor ability of binding to heparin binding site which is a crucial factor in ligand-receptor complex formation. β-Klotho has been identified as co-factor required for FGF-19, 21, 23 signaling. It can obviously increase ligand-receptor affinity. Unlike most FGFs which bind to and activate more than one FGF receptor, FGF19 is a specific ligand for FGF R4. In FGF-19 transgenic mice, reducing liver triglycerides, increasing fatty acid oxidation, reducing glucose levels and improving insulin sensitivity can be observed. |
Source : | E.coli |
Species : | Human |
Form : | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4. |
Bio-activity : | Assay #1: Fully biologically active when compared to standard. The biological activity is measured by its binding ability in a functional ELISA. Immobilized rHuFGF R4 at 5 µg/ml can bind rHuFGF-19 with a linear range of 3-200 ng/ml.Assay #2: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 150 ng/ml, corresponding to a specific activity of > 6.7 × 10³ IU/mg. |
Molecular Mass : | Approximately 21.8 kDa, a single non-glycosylated polypeptide chain containing 195 amino acids. |
Protein length : | 195 |
AA Sequence : | MRPLAFSDAGPHVHYGWGDPIRLRH LYTSGPHGLSSCFLRIRADGVVDCA RGQSAHSLLEIKAVALRTVAIKGVH SVRYLCMGADGKMQGLLQYSEEDCA FEEEIRPDGYNVYRSEKHRLPVSLS SAKQRQLYKNRGFLPLSHFLPMLPM VPEEPEDLRGHLESDMFSSPLETDS MDPFGLVTGLEAVRSPSFEK |
Endotoxin : | Less than 1 EU/µg of rHuFGF-19 as determined by LAL method. |
Purity : | >95% by SDS-PAGE and HPLC analysis. |
Storage : | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions. |
Gene Name : | FGF19 |
Official Symbol : | FGF19 |
Synonyms : | FGF19; fibroblast growth factor 19; FGF-19; |
Gene ID : | 9965 |
mRNA Refseq : | NM_005117 |
Protein Refseq : | NP_005108 |
MIM : | 603891 |
UniProt ID : | O95750 |
Products Types
◆ Recombinant Protein | ||
FGF19-325H | Active Recombinant Human FGF19 Protein (Arg23-Lys216), C-His tagged, Animal-free, Carrier-free | +Inquiry |
FGF19-1484H | Recombinant Human FGF19 Protein, His-tagged | +Inquiry |
FGF19-4109H | Recombinant Human FGF19 Protein, GST-tagged | +Inquiry |
FGF19-75H | Recombinant Active Human FGF19 Protein, His-tagged(C-ter) | +Inquiry |
FGF19-906H | Recombinant Human FGF19 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FGF19-6244HCL | Recombinant Human FGF19 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionFGF19 expression is regulated by bile acids and other factors. Its secretion and activity are influenced by nutrient availability, signaling pathways, and interactions with bile acid receptors.
Targeting FGF19 holds therapeutic potential for metabolic disorders. Challenges include achieving tissue-specific effects and understanding the long-term consequences of manipulating FGF19 signaling.
FGF19 regulates bile acid synthesis in the liver and influences the enterohepatic circulation, impacting metabolic health by modulating lipid and glucose metabolism.
FGF19 influences gut hormone secretion, including the release of glucagon-like peptide-1 (GLP-1). This regulation contributes to its metabolic effects, such as enhanced insulin sensitivity and reduced food intake.
Dysregulation of FGF19 is implicated in metabolic diseases, including obesity and NAFLD. Altered FGF19 signaling may contribute to aberrant bile acid and lipid metabolism in these conditions.
Customer Reviews (3)
Write a reviewTop-notch protein quality! It's our go-to for reliable and reproducible results.
This product simplifies our research. It's a reliable tool that we can count on.
If you're in the lab, you need this product. It streamlines processes and is a lab necessity.
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