fgfr2
Share
  • Official Full Name
  • fibroblast growth factor receptor 2
  • Background
  • The K-sam gene was cloned and identified as a fibroblast growth factor receptor (FGFR) 2 gene. K-sam generates several variant transcripts by alternative splicing, including those coding for soluble forms of the receptor. Among the K-sam cDNAs coding for the transmembrane types of the protein, two major variations have been identified; the alternative choice of the exons coding for the extracellular third immunoglobulin-like domain determines ligand specificity, and the carboxyl terminus variation apparently regulates growth and differentiation signals transduced by the K-sam molecules. In particular, one with the KGF-binding motif and a short carboxyl terminus showed not only higher transforming activity for NIH3T3 cells and higher mitogenic response to KGF in karatinocytes, but also greater resistance to induction of differentiation in L6 myoblasts than other K-sam variants. In the NIH3T3 transformants, the K-sam protein with the short carboxyl terminus showed a lower level of autophosphorylation. Expression of the K-sam protein is apparently correlated with the prognosis of poorly differentiated types of gastric cancers.
  • Synonyms
  • FGFR2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; Crouzon syndrome; Pfeiffer syndrome; fibroblast growth factor receptor 2; OTTHUMP00000020623; Keratinocyte growth factor receptor; OTTHUMP00000020624; OTTHUMP00000020625; OTTHUMP00000020626; OTTHUMP00000020627; OTTHUMP00000020628; OTTHUMP00000020629; OTTHUMP00000020630; OTTHUMP00000020631; bacteria-expressed kinase; OTTHUMP00000020632; FGFR-2; BEK fibroblast growth factor receptor; FGF receptor; EC 2.7.10.1; hydroxyaryl-protein kinase; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4; craniofacial dysostosis 1; Jackson-Weiss syndrome; KSAM; CD332 antigen; FLJ98662; EC 2.7.10; OTTHUMP00000020621
Cat.#:FGFR2-2055HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2 Protein, DDK-tagged
+Inquiry
Cat.#:FGFR2-4128HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR2 Protein
+Inquiry
Cat.#:FGFR2-4130HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human FGFR2 Protein, GST-tagged
+Inquiry
Cat.#:FGFR2-5418HTag:his
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2, His-tagged
+Inquiry
Cat.#:Fgfr2-542MTag:Fc
Source (Host):S. frugiperdaSpecies:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged
+Inquiry
Cat.#:Fgfr2-551MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Fibroblast Growth Factor Receptor 2, Fc-tagged
+Inquiry
Cat.#:FGFR2-02HTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2, Fc-tagged
+Inquiry
Cat.#:FGFR2-102HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor
+Inquiry
Cat.#:FGFR2-18HTag:GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2 protein, GST-tagged
+Inquiry
Cat.#:FGFR2-28889THTag:
Source (Host):Species:Human
Product nameRecombinant Human FGFR2
+Inquiry
Cat.#:FGFR2-31452THTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human FGFR2, Fc-tagged
+Inquiry
Cat.#:FGFR2-314HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, GST-tagged, Active
+Inquiry
Cat.#:FGFR2-481HTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, Fc Chimera
+Inquiry
Cat.#:FGFR2-488HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2
+Inquiry
Cat.#:FGFR2-489HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2
+Inquiry
Cat.#:FGFR2-5002HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2
+Inquiry
Cat.#:FGFR2-595HTag:Fc
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Fibroblast Growth Factor Receptor 2, Fc Chimera
+Inquiry
Cat.#:FGFR2-607HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR2, His-tagged, Biotinylated
+Inquiry
Cat.#:FGFR2-608HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human FGFR2, Fc-tagged, Biotinylated
+Inquiry
Cat.#:FGFR2-621HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2, His tagged
+Inquiry
Cat.#:FGFR2-690HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human FGFR2, Fc Chimera
+Inquiry
Cat.#:FGFR2-691HTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, Fc Chimera
+Inquiry
Cat.#:FGFR2-705HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2, Fc-His tagged
+Inquiry
Cat.#:FGFR2-7303HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR2, His & GST tagged
+Inquiry
Cat.#:FGFR2-777HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2 Protein, Fc-tagged
+Inquiry
Cat.#:FGFR2-778HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2 Protein, His-tagged
+Inquiry
Cat.#:FGFR2-791HTag:DDK/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human FGFR2 Protein, DDK/His-tagged
+Inquiry
Cat.#:FGFR2-821HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, GST-tagged
+Inquiry
Cat.#:FGFR2-82HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2, MYC/DDK-tagged
+Inquiry
Cat.#:FGFR2-86HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human FGFR2, GST-tagged
+Inquiry
Cat.#:FGFR2-87HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human FGFR2, His-tagged
+Inquiry
Cat.#:Fgfr2-368MTag:Fc Chimera
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Fgfr2, Fc Chimera
+Inquiry
Cat.#:Fgfr2-427MTag:Fc Chimera
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Fgfr2, Fc Chimera
+Inquiry
Cat.#:Fgfr2-501MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr2, Fc-tagged
+Inquiry
Cat.#:Fgfr2-502MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Fgfr2, His-tagged
+Inquiry
Cat.#:Fgfr2-638MTag:Fc
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Fgfr2 Protein, Fc Chimera
+Inquiry
Cat.#:FGFR2-1752RTag:
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FGFR2 Protein
+Inquiry
Cat.#:FGFR2-1753RTag:hIgG1
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FGFR2 Protein, hIgG1-tagged
+Inquiry
Cat.#:FGFR2-1754RTag:hIgG4
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus Monkey FGFR2 Protein, hIgG4-tagged
+Inquiry
Cat.#:FGFR2-6871CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken FGFR2
+Inquiry
Cat.#:FGFR2-8029ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish FGFR2
+Inquiry
Cat.#:FGFR2-2578HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human FGFR2 cell lysate
+Inquiry
Cat.#:FGFR2-428HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human FGFR2 cell lysate
+Inquiry
Cat.#:FGFR2-001MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse FGFR2 cell lysate
+Inquiry
Cat.#:Kit-0341Tag:
Source (Host):Species:
Product nameFGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit
+Inquiry

Involved Pathway

FGFR2 involved in several pathways and played different roles in them. We selected most pathways FGFR2 participated on our site, such as MAPK signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGFR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
AKT2L; FGF21; HSPA1A; MAPK12; RASA1; GRB2A; CACNA1D; PDGFA; FGFR1A; PRKCBA
Ras signaling pathway
TBK1; RASA4; STK4; RALGDS; RRAS; PDGFRA; KIT; FGF19; FGF14; PLA2G6
Rap signaling pathway
PFN2; PRKD1; RAP1B; MAGI2; FGF2; FGF5; PFN3; MAPK13; Adcy4; PRKCA
Endocytosis
RHOAC; WIPF2; SH3GL3B; CBLB; PIP5K1AA; FGFR4; PRKCZ; IST1; ITCH; HLA-F
PIK-Akt signaling pathway
PIK3CG; MTCP1; ITGA10; COL6A6; TCL1; FGF7; ITGB8; FGF16; FGFR2; PKN2
Signaling pathways regulating pluripotency of stem cells
ZFHX3; ISL1; PCGF1; BMPR2; HRAS; KRAS; SMAD2; JARID2; SMARCAD1; MAPK12
Regulation of actin cytoskeleton
KRAS; CD14; MYL1; PIP5K1AA; FGF10A; ITGAM; Itgam&Itgb2; PTK2; ROCK2A; ARPC4L
Pathways in cancer
PIK3R2; XIAP; CDC42; CKS2; GNG8; BRAF; LAMA5; RUNX1; STAT5B; BID
Prostate cancer
RELA; PDGFD; SPRY1; PDPK1; SRD5A2; HSP90B1; PIK3CB; FOXO1; PTEN; ATF4
Central carbon metabolism in cancer
HK2; LDHA; SLC7A5; SIRT6; PDGFRA; PFKM; PDHA1; G6PD; RET; PDHA2

Protein Function

FGFR2 has several biochemical functions, for example, ATP binding, fibroblast growth factor binding, fibroblast growth factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGFR2 itself. We selected most functions FGFR2 had, and list some proteins which have the same functions with FGFR2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCC6; KALRN; MYO1C; CDK13; ATP4A; ERBB2; TGFBR2; PIP4K2B; NAV2; JAK2A
Function fibroblast growth factor binding
Related Protein FGFRL1; RPS2; FIBP; RPS19; FIBPB; FGFR4; FGFR3; Api5; FGFBP3; CEP57
Function fibroblast growth factor-activated receptor activity
Related Protein FGFR4; FGFR1B; FGFR1; FGFR1A; FGFRL1; FGFR3; FGFR2
Function heparin binding
Related Protein AZU1; F11; ECM2; ZFP207; CCL7; MMP7; FGF12; RSPO3; RPL22; Itgam&Itgb2
Function protein binding
Related Protein PRKX; SLC25A4; C10orf137; CD93; NDUFS7; MSRB3; KRT38; GNE; BORA; HBZ
Function protein homodimerization activity
Related Protein RXRB; TNNC1; C6orf108; TOX3; ZNF174; GALE; DMRTB1; CHUK; WWTR1; MYOM3
Function protein tyrosine kinase activity
Related Protein EPHB4B; FES; EPHA4A; MAP3K9; KDR; ABL2; ZNF143B; FYN; PTK2AB; INSR

Interacting Protein

FGFR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGFR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGFR2.
FGF1; ssr; GRB2; FGF2; FGF10

FGFR2 Related Articles

De Vita, F; Di Martino, N; et al. Clinical management of advanced gastric cancer: The role of new molecular drugs. WORLD JOURNAL OF GASTROENTEROLOGY 20:14537-14558(2014).
Zhang, Y; Pan, TC; et al. Resistance to Cetuximab in EGFR-Overexpressing Esophageal Squamous Cell Carcinoma Xenografts Due to FGFR2 Amplification and Overexpression. JOURNAL OF PHARMACOLOGICAL SCIENCES 126:77-83(2014).

FGFR2 Related Gene Family

Cytokines