Recombinant Human Fibroblast Growth Factor Receptor 2
Cat.No. : | FGFR2-489H |
- Specification
- Gene Information
- Related Products
Cat. No. : | FGFR2-489H |
Description : | This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Three alternatively spliced variants encoding different isoforms have been described. The heparin-binding growth factors are angiogenic agents in vivo and are potent mitogens for a variety of cell types in vitro. There are differences in the tissue distribution and concentration of these 2 growth factors. |
Source : | Mammalian cells |
Molecular Weight : | The predicted molecular weight of Recombinant Human FGF R2α (IIIc) is Mr 66 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100-110 kDa. |
State Of Matter : | Lyophilized. |
Purity : | > 90% by SDS Page and analyzed by silver stain. |
Endotoxin : | < 0.1 ng per 1 µg as determined by the LAL method. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ] |
Synonyms : | FGFR2; fibroblast growth factor receptor 2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332; K-SAM; FLJ98662; FGF receptor; OTTHUMP00000020624; OTTHUMP00000020626; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14; EC 2.7.10.1; Crouzon syndrome; Pfeiffer syndrome; craniofacial dysostosis 1; Jackson-Weiss syndrome; Keratinocyte growth factor receptor 2; K-SAM; CD332 antigen; BEK fibroblast growth factor receptor; FGF receptor |
Gene ID : | 2263 |
mRNA Refseq : | NM_000141 |
Protein Refseq : | NP_000132 |
UniProt ID : | P21802 |
Chromosome Location : | 10q25.3-q26 |
MIM : | 176943 |
Pathway : | Endocytosis; MAPK signaling pathway; Pathways in cancer; Prostate cancer; Regulation of actin cytoskeleton |
Function : | ATP binding; fibroblast growth factor receptor activity; heparin binding; nucleotide binding; protein binding; receptor activity; transferase activity |
Products Types
◆ Recombinant Protein | ||
Fgfr2-1501R | Recombinant Rat Fgfr2 Protein, His-tagged | +Inquiry |
FGFR2-5418H | Recombinant Human Fibroblast Growth Factor Receptor 2, His-tagged | +Inquiry |
FGFR2-058H | Recombinant Human FGFR2 Protein | +Inquiry |
FGFR2-4128H | Recombinant Human FGFR2 Protein | +Inquiry |
Fgfr2-135M | Recombinant Mouse Fgfr2 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
FGFR2-001MCL | Recombinant Mouse FGFR2 cell lysate | +Inquiry |
FGFR2-2578HCL | Recombinant Human FGFR2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0341 | FGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
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Q&As (5)
Ask a questionMutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.
Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.
Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.
FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.
Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.
Customer Reviews (3)
Write a reviewThe FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.
What sets FGFR2 apart is the manufacturer's unparalleled technical support.
The versatility of the FGFR2 protein makes it a valuable asset in my research.
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