Recombinant Human FGFR2 Protein
Cat.No. : | FGFR2-4128H |
Product Overview : | Human FGFR2 full-length ORF (NP_000132.1) recombinant protein without tag. |
- Specification
- Gene Information
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Description : | The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq |
Source : | Wheat Germ |
Species : | Human |
Form : | Liquid |
Molecular Mass : | 92 kDa |
AA Sequence : | MVSWGRFICLVVVTMATLSLARPSF SLVEDTTLEPEEPPTKYQISQPEVY VAAPGESLEVRCLLKDAAVISWTKD GVHLGPNNRTVLIGEYLQIKGATPR DSGLYACTASRTVDSETWYFMVNVT DAISSGDDEDDTDGAEDFVSENSNN KRAPYWTNTEKMEKRLHAVPAANTV KFRCPAGGNPMPTMRWLKNGKEFKQ EHRIGGYKVRNQHWSLIMESVVPSD KGNYTCVVENEYGSINHTYHLDVVE RSPHRPILQAGLPANASTVVGGDVE FVCKVYSDAQPHIQWIKHVEKNGSK YGPDGLPYLKVLKAAGVNTTDKEIE VLYIRNVTFEDAGEYTCLAGNSIGI SFHSAWLTVLPAPGREKEITASPDY LEIAIYCIGVFLIACMVVTVILCRM KNTTKKPDFSSQPAVHKLTKRIPLR RQVTVSAESSSSMNSNTPLVRITTR LSSTADTPMLAGVSEYELPEDPKWE FPRDKLTLGKPLGEGCFGQVVMAEA VGIDKDKPKEAVTVAVKMLKDDATE KDLSDLVSEMEMMKMIGKHKNIINL LGACTQDGPLYVIVEYASKGNLREY LRARRPPGMEYSYDINRVPEEQMTF KDLVSCTYQLARGMEYLASQKCIHR DLAARNVLVTENNVMKIADFGLARD INNIDYYKKTTNGRLPVKWMAPEAL FDRVYTHQSDVWSFGVLMWEIFTLG GSPYPGIPVEELFKLLKEGHRMDKP ANCTNELYMMMRDCWHAVPSQRPTF KQLVEDLDRILTLTTNEEYLDLSQP LEQYSPSYPDTRSSCSSGDDSVFSP DPMPYEPCLPQYPHINGSVKT |
Applications : | Antibody Production Functional Study Compound Screening |
Usage : | Heating may cause protein aggregation. Please do not heat this product before electrophoresis. |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
Gene Name : | FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ] |
Official Symbol : | FGFR2 |
Synonyms : | FGFR2; fibroblast growth factor receptor 2; bacteria expressed kinase, BEK, CFD1, craniofacial dysostosis 1, Jackson Weiss syndrome, JWS, keratinocyte growth factor receptor, KGFR; CD332; CEK3; Crouzon syndrome; ECT1; K SAM; Pfeiffer syndrome; TK14; TK25; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14; BEK; JWS; CFD1; KGFR; BFR-1; K-SAM; FLJ98662; |
Gene ID : | 2263 |
mRNA Refseq : | NM_000141 |
Protein Refseq : | NP_000132 |
MIM : | 176943 |
UniProt ID : | P21802 |
Products Types
◆ Recombinant Protein | ||
FGFR2-34H | Recombinant Active Human FGFR2 (N549K) Protein (285-end), N-GST-tagged | +Inquiry |
FGFR2-4130H | Recombinant Human FGFR2 Protein, GST-tagged | +Inquiry |
FGFR2-186H | Recombinant Human FGFR2 Protein, His (Fc)-Avi-tagged | +Inquiry |
FGFR2-5418H | Recombinant Human Fibroblast Growth Factor Receptor 2, His-tagged | +Inquiry |
FGFR2-33H | Recombinant Active Human FGFR2 (M420I) Protein (285-end), N-GST-tagged | +Inquiry |
◆ Lysates | ||
FGFR2-001MCL | Recombinant Mouse FGFR2 cell lysate | +Inquiry |
FGFR2-2578HCL | Recombinant Human FGFR2 cell lysate | +Inquiry |
FGFR2-428HCL | Recombinant Human FGFR2 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0341 | FGFR2 Kinase (Human) Assay/Inhibitor Screening Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionMutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.
Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.
Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.
FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.
Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.
Customer Reviews (3)
Write a reviewThe FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.
What sets FGFR2 apart is the manufacturer's unparalleled technical support.
The versatility of the FGFR2 protein makes it a valuable asset in my research.
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