Recombinant Human Fibroblast Growth Factor Receptor 2, His-tagged

• Cat.No.: FGFR2-5418H
• Product Overview: Recombinant humanFGFR2 cytoplasmic domain (amino acids 403-822), His-tagged. No specialmeasures were taken to activate this kinase.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 403-822 a.a.
• Description: This protein functions as amodifier of endothelial cell migration and proliferation, as well as anangiogenic factor. It acts as a mitogen for a variety of mesoderm- andneuroectoderm-derived cells in vitro, thus is thought to be involved inorganogenesis. Three alternatively spliced variants encoding differentisoforms have been described. The heparin-binding growth factors areangiogenic agents in vivo and are potent mitogens for a variety of cell typesin vitro. There are differences in the tissue distribution and concentrationof these 2 growth factors.
• MolecularWeight: 52.1 kDa
• Purity: ≥ 90% as determinedby SDS-PAGE analysis
• Specific Activity: 2700nmole of phosphate transferred to poly [Glu,Tyr] 4:1 substrate per minute permg oftotalprotein at 30°C. Activity determined at a final protein concentration of 1μg/ml.
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: FGFR2

Gene Information

• Gene Name: FGFR2 fibroblast growth factorreceptor 2 [ Homo sapiens ]
• Synonyms: FGFR2; fibroblast growth factorreceptor 2; BEK; JWS; CEK3; CFD1; ECT1; KGFR; TK14; TK25; BFR-1; CD332;K-SAM; FLJ98662; FGFR2; KSAR; FGFR-2; KSAM; OTTHUMP00000020621;OTTHUMP00000020629; BEK fibroblast growth factor receptor; CD332 antigen; FGFreceptor; Jackson-Weiss syndrome; Keratinocyte growth factor receptor 2;bacteria-expressed kinase; craniofacial dysostosis 1; fibroblast growthfactor receptor 2; hydroxyaryl-protein kinase; keratinocyte growth factorreceptor; protein tyrosine kinase, receptor like 14; soluble FGFR4 variant 4
• Gene ID: 2263
• mRNA Refseq: NM_000141
• Protein Refseq: NP_000132
• MIM: 176943
• UniProt ID: P21802
• Chromosome Location: 10q26
• Pathway: Angiogenesis;Downstream signaling of activated FGFR; Endocytosis; FGF signaling pathway;FGFR ligand binding and activation; FGFR2 ligand binding and activation;FRS2-mediated cascade; IRS-mediated signalling; Insulin receptor signallingcascade; MAPK signaling pathway; Negative regulation of FGFR signaling; PI-3Kcascade; Pathways in cancer; Regulation of Actin Cytoskeleton; SHC-mediatedcascade
• Function: ATP binding; fibroblast growthfactor receptor activity; heparin binding; nucleotide binding; proteinbinding; receptor activity; transferase activity