Recombinant Human FGFR2 Protein, GST-tagged

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Recombinant Human FGFR2 Protein, GST-tagged

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Cat.No. : FGFR2-4130H
Product Overview : Human FGFR2 full-length ORF ( AAH39243.2, 1 a.a. - 723 a.a.) recombinant protein with GST-tag at N-terminal.
Description : The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 105.27 kDa
AA Sequence : MGLTSTWRYG RGPGIGTVTM VSWGRFICLV VVTMATLSLA RPSFSLVEDT TLEPEGAPYW TNTEKMEKRL HAVPAANTVK FRCPAGGNPM PTMRWLKNGK EFKQEHRIGG YKVRNQHWSL IMESVVPSDK GNYTCVVENE YGSINHTYHL DVVERSPHRP ILQAGLPANA STVVGGDVEF VCKVYSDAQP HIQWIKHVEK NGSKYGPDGL PYLKVLKAAG VNTTDKEIEV LYIRNVTFED AGEYTCLAGN SIGISFHSAW LTVLPAPGRE KEITASPDYL EIAIYCIGVF LIACMVVTVI LCRMKNTTKK PDFSSQPAVH KLTKRIPLRR QVSAESSSSM NSNTPLVRIT TRLSSTADTP MLAGVSEYEL PEDPKWEFPR DKLTLGKPLG EGCFGQVVMA EAVGIDKDKP KEAVTVAVKM LKDDATEKDL SDLASEMEMM KMIGKHENII NLLGACTQDG PLYVIVEYAS KGNLREYLRA RRPPGMEYSY DINRVPEEQM TFEDLVSCTY QLARGMEYLA SQKCIHRDLA ARNVLVTENN VMKIADFGLA RDINNIDYYK KTTNGRLPVK WMAPEALFDR VYTHQSDVWS FGVLMWEIFT LGGSPYPGIP VEELLKLLKE GHRMDKPANC TNELYMMMRD CWHAVPSQRP TFKQLVEDLD RILTLTTNEE YLDLSQPLEQ YSPSYPDTRS SCSSGDDSVF SPDPMPYEPC LPQYPHINGS VKT
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : FGFR2 fibroblast growth factor receptor 2 [ Homo sapiens ]
Official Symbol : FGFR2
Synonyms : FGFR2; fibroblast growth factor receptor 2; bacteria expressed kinase, BEK, CFD1, craniofacial dysostosis 1, Jackson Weiss syndrome, JWS, keratinocyte growth factor receptor, KGFR; CD332; CEK3; Crouzon syndrome; ECT1; K SAM; Pfeiffer syndrome; TK14; TK25; FGFR-2; FGF receptor; soluble FGFR4 variant 4; bacteria-expressed kinase; hydroxyaryl-protein kinase; keratinocyte growth factor receptor; BEK fibroblast growth factor receptor; protein tyrosine kinase, receptor like 14; BEK; JWS; CFD1; KGFR; BFR-1; K-SAM; FLJ98662;
Gene ID : 2263
mRNA Refseq : NM_000141
Protein Refseq : NP_000132
MIM : 176943
UniProt ID : P21802

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