Recombinant Mouse Fgfr2 protein(Met1-Glu263), hFc-tagged

• Cat.No.: Fgfr2-501M
• Product Overview: Recombinant Mouse FGFR2 (AAA39377.1) (Met1-Glu263) was expressed in HEK293 with the Fc region of Human IgG1 at the C-terminus.

Specification

• Source: HEK293
• Species: Mouse
• Tag: C-hFc
• Protein length: Met1-Glu263
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Bio-activity: Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.4-2.4 ng/mL
• Molecular Mass: The recombinant mouse FGFR2 comprises 483 amino acids and has a predicted molecular mass of 54.1 kDa. The apparent molecular mass of the protein is approximately 89.9 kDa in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: Fgfr2 fibroblast growth factor receptor 2 [ Mus musculus ]
• Official Symbol: Fgfr2
• Synonyms: FGFR2; fibroblast growth factor receptor 2; keratinocyte growth factor receptor; Bek; svs; KGFR; Fgfr7; Fgfr-2; Fgfr-7; KGFRTr; AU043015; AW556123; MGC102519
• Gene ID: 14183
• mRNA Refseq: NM_010207
• Protein Refseq: NP_034337

Reviews

08/24/2017

The FGFR2 protein is an outstanding product that possesses exceptional quality, making it an ideal choice for my experimental needs.

03/05/2017

What sets FGFR2 apart is the manufacturer's unparalleled technical support.

09/13/2016

The versatility of the FGFR2 protein makes it a valuable asset in my research.

Q&As

How is FGFR2 linked to developmental disorders?

Mutations in FGFR2 are associated with various developmental disorders, impacting the development of the skull, limbs, and other structures.

Can FGFR2 be targeted for personalized cancer therapy?

Yes, targeting FGFR2 mutations allows for more personalized and precise therapeutic approaches in cancer treatment.

Are there clinical trials involving FGFR2 inhibitors?

Yes, numerous clinical trials are underway to evaluate the efficacy of FGFR2 inhibitors in treating various cancers and developmental disorders.

How does FGFR2 impact wound healing?

FGFR2 is involved in the regulation of cell migration and tissue repair, contributing to the process of wound healing.

Are there any side effects associated with FGFR2 inhibitors?

Common side effects of FGFR2 inhibitors include fatigue, nausea, and hypertension, which are being studied for better management.