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Fzd8

  • Official Full Name

    frizzled family receptor 8

  • Overview

    This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain;proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled;receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human;cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the;extracellular cysteine-rich domain of a similar mouse protein has been determined.
  • Synonyms

    FZD8; frizzled family receptor 8; frizzled (Drosophila) homolog 8 , frizzled 8, seven transmembrane spanning receptor , frizzled homolog 8 (Drosophila); frizzled-8; frizzled homolog 8; frizzled 8, seven transmembrane spanning receptor; FZ-8; hFZ8;

  • Recombinant Proteins
  • Therapeutic Proteins
  • Protein Pre-coupled Magnetic Beads
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • Xenopus laevis (African clawed frog)
  • CHO
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FZD8-597H Active Recombinant Human Frizzled Family Receptor 8, Fc-tagged CHO Fc
Human FZD8-596H Recombinant Human FZD8(Ala28-Pro172) Protein, C-6*His-tagged HEK293 His
Human FZD8-P012H Recombinant Human FZD8, Fc-tagged therapeutic protein Fc
Human FZD8-4600H Recombinant Human FZD8 Protein, GST-tagged Wheat Germ GST
Human FZD8-946HB Recombinant Human FZD8 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ala28-Pro172
Mouse Fzd8-593M Active Recombinant Mouse Frizzled Homolog 8 (Drosophila), Fc-tagged Mammalian cells Fc
Mouse FZD8-6122M Recombinant Mouse FZD8 Protein Mammalian Cell His
Mouse Fzd8-55M-B Recombinant Mouse Fzd8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Fzd8-55M Recombinant Mouse Fzd8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat FZD8-2432R Recombinant Rat FZD8 Protein Mammalian Cell His
Rat FZD8-2088R-B Recombinant Rat FZD8 Protein Pre-coupled Magnetic Beads HEK293
Rat FZD8-2088R Recombinant Rat FZD8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Gallus gallus (Chicken) RFL15847GF Recombinant Full Length Chicken Frizzled-8(Fzd8) Protein, His-Tagged E.coli expression system His Full Length (1-217)
Homo sapiens (Human) RFL24588HF Recombinant Full Length Human Frizzled-8(Fzd8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-694)
Mus musculus (Mouse) RFL21170MF Recombinant Full Length Mouse Frizzled-8(Fzd8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-685)
Rattus norvegicus (Rat) RFL3704RF Recombinant Full Length Rat Frizzled-8(Fzd8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (28-684)
Xenopus laevis (African clawed frog) RFL30853XF Recombinant Full Length Xenopus Laevis Frizzled-8(Fzd8) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-581)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Fzd8 Related Articles
  • Fzd8 Related Signal Pathway

Fzd8 involved in several pathways and played different roles in them. We selected most pathways Fzd8 participated on our site, such as Wnt signaling pathway, Hippo signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with Fzd8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwaySOX17;SFRP4;MAPK10;WNT16;DKK4;LRP5;FRAT2;SERPINF1;WNT3A
Hippo signaling pathwayPPP2CB;AJUBA;WNT9B;CCND2;YWHAZ;ID1;FZD6;CRB1;TGFB1
Signaling pathways regulating pluripotency of stem cellsINHBB;STAT3;SOX2;MAPK12;FZD9;WNT5A;MEIS1;WNT6;WNT8A
MelanogenesisCALM4;FZD3A;PLCB4;WNT3;PRKACG;WNT11;GNAO1B;WNT9B;WNT2BA
HTLV-I infectionCALR;ETS2;MAPK8;BUB1B;XPO1;WNT10B;STAT5B;HLA-DOB;NFKB2
Pathways in cancerFH;WNT8A;TRAF5;MTOR;TGFB2;FGF10;WNT2;MSH6;RELA
Proteoglycans in cancerCAV2;PIK3CB;TGFB1;FN1;PIK3R2;RAF1;FZD9;ITGA5;GAB1
Basal cell carcinomaAPC2;WNT2B;TP53;SETD6;AXIN1;WNT2;LEF1;FZD6;TCF7L2

Fzd8 has several biochemical functions, for example, G-protein coupled receptor activity, PDZ domain binding, Wnt-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fzd8 itself. We selected most functions Fzd8 had, and list some proteins which have the same functions with Fzd8. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled receptor activityGPR45;GPR150;OR51B2;GLP2R;RGRA;GPR157;OR2A4;FZD2;FZD8
PDZ domain bindingCFTR;LIN7C;TGFBR3;SDC2;KIF14;NLGN1;GRM7;Fzd4;FZD8
Wnt-activated receptor activityFZD2;LRP6;FZD3;FZD9;FZD3B;FZD7B;FZD7;FZD3A;LRP2A
Wnt-protein bindingGPR177;FZD8B;FZD7A;ROR1;WLS;FZD6;FZD2;FZD1;SFRP2
protein bindingHCFC1;TCP1;LRRC6;PPIA;VPS52;KCNH7;DEDD;PIAS2;DDX39B
receptor bindingGRIN2A;TNFSF18;EDN3;Ar;P2RX7;ANKRD13C;INHA;CCL17;NPPB
ubiquitin protein ligase bindingYWHAE;FZD8;KCNQ3;HERC2;SCN5A;BAG4;NAE1;ANKRD32;PRKACB

Fzd8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fzd8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Fzd8.

c1q_mouse_complex; WNT3A; SDCBP; C1qa

Pauletto, M; Milan, M; et al. Insights into Molecular Features of Venerupis decussata Oocytes: A Microarray-Based Study. PLOS ONE 9:-(2014).
Xiao, XA; Wang, P; et al. GPCR-2L: predicting G protein-coupled receptors and their types by hybridizing two different modes of pseudo amino acid compositions. MOLECULAR BIOSYSTEMS 7:911-919(2011).
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