galnt1

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galnt1

Official Full Name UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
Background This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature.
Synonyms GALNT1; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1); polypeptide N-acetylgalactosaminyltransferase 1; GalNAc T1; protein UDP acetylgalactosaminyltransferase 1; GalNAc transferase 1; GalNAc-T1; GALNT 1; GALT1_HUMAN; Polypeptide GalNAc transferase 1; Polypeptide N acetylgalactosaminyltransferase 1; Polypeptide N-acetylgalactosaminyltransferase 1 soluble form; pp GaNTase 1; pp-GaNTase 1; Protein-UDP acetylgalactosaminyltransferase 1; UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 1; UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1 (GalNAc T1); UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GALNT1-26H Recombinant Human GALNT1 Protein, His-tagged NS0 His
    Human GALNT1-676H Recombinant Human GALNT1 Protein, His-tagged Insect Cell His
    Human GALNT1-1253H Recombinant Human GALNT1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human GALNT1-13130H Recombinant Human GALNT1, GST-tagged E.coli GST
    Human GALNT1-27302TH Recombinant Human GALNT1 Wheat Germ N/A
    Human GALNT1-27304TH Recombinant Human GALNT1 Wheat Germ N/A
    Human GALNT1-4689H Recombinant Human GALNT1 Protein, GST-tagged Wheat Germ GST
    Human GALNT1-680HCL Recombinant Human GALNT1 cell lysate N/A
    Mouse GALNT1-6179M Recombinant Mouse GALNT1 Protein Mammalian Cell His
    Rat GALNT1-2465R Recombinant Rat GALNT1 Protein Mammalian Cell His
    Rhesus Macaque GALNT1-1805R Recombinant Rhesus monkey GALNT1 Protein, His-tagged Mammalian Cell His
    Chicken GALNT1-1523C Recombinant Chicken GALNT1 Mammalian Cell His

    galnt1 involved in several pathways and played different roles in them. We selected most pathways galnt1 participated on our site, such as Mucin type O-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with galnt1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Mucin type O-Glycan biosynthesis B3GNT6; GALNT5; GALNTL6; GALNT11; POC1B-GALNT4; GALNT9; POC1BL; GALNT10; GALNT18; C1GALT1C1
    Metabolic pathways UGT2B15; TPI1A; ALG10B; AGPAT9L; IMPAD1; CYP2P7; FASN; SAT1A.1; POLR2K; HPSE

    galnt1 has several biochemical functions, for example, carbohydrate binding, manganese ion binding, polypeptide N-acetylgalactosaminyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by galnt1 itself. We selected most functions galnt1 had, and list some proteins which have the same functions with galnt1. You can find most of the proteins on our site.

    Function Related Protein
    carbohydrate binding CLEC1B; MGAT2; NCAN; KLRG1; KLRB1B; EVA1C; GFPT1; KRT1; FBXO6; Siglec1
    manganese ion binding GYLTL1B; MPPE1; PPM1M; LAP3; LARGE; GALNT2; SLC11A2; GLUL; PPM1AB; B4GALT7
    polypeptide N-acetylgalactosaminyltransferase activity GALNT10; GALNT1; GALNT5; GALNT4; GALNT14; GALNTL2; GALNT7; GALNTL1; GALNT3; GALNT6

    galnt1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with galnt1 here. Most of them are supplied by our site. Hope this information will be useful for your research of galnt1.

    SEC23A; Tgfbr1

    Gregersen, VR; Gustavsson, F; et al. Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. JOURNAL OF DAIRY SCIENCE 98:1261-1272(2015).
    Tian, E; Stevens, SR; et al. Galnt1 Is Required for Normal Heart Valve Development and Cardiac Function. PLOS ONE 10:-(2015).

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