gdf5
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  • Official Full Name
  • growth differentiation factor 5
  • Background
  • The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
  • Synonyms
  • GDF5; growth differentiation factor 5; growth/differentiation factor 5; BMP14; cartilage derived morphogenetic protein 1; CDMP1; GDF-5; CDMP-1; radotermin; cartilage-derived morphogenetic protein-1; OS5; LAP4; SYNS2
Cat.#:GDF5-275HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDF5 Protein, His-tagged
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Cat.#:GDF5-4827HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human GDF5 Protein, GST-tagged
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Cat.#:Gdf5-276MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdf5 Protein, His-tagged
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Cat.#:Gdf5-651MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdf5 Protein
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Cat.#:GDF5-13211HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDF5, GST-tagged
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Cat.#:GDF5-27470THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDF5
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Cat.#:GDF5-27678THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human GDF5, His-tagged
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Cat.#:GDF-5300HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Differentiation Factor 5, His-tagged
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Cat.#:GDF5-34HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Growth Differentiation Factor 5
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Cat.#:Gdf5-512MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Gdf5 protein, His-tagged
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Cat.#:GDF5-6288MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse GDF5 Protein
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Cat.#:GDF5-5910CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken GDF5
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Cat.#:Gdf5-720MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Growth Differentiation Factor 5
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Cat.#:GDF5-5968HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human GDF5 293 Cell Lysate
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Involved Pathway

GDF5 involved in several pathways and played different roles in them. We selected most pathways GDF5 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IFNA6; CRFB4; CXCL2; TNFSF4; IFNA13; TGFBR2; CCL15; CCL20; CD40; CCL23
TGF-beta signaling pathway
LFT1; LEFTY1; BMP5; BMP8A; LEFTY2; RHOAA; TFDP1A; SMAD9; CHRD; MAPK3
Hippo signaling pathway
APC; BMP7; FZD5; FBXW11; DLG1; SOX2; MOBKL1A; FZD10; ACTG1; WNT4

Protein Function

GDF5 has several biochemical functions, for example, BMP binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF5 itself. We selected most functions GDF5 had, and list some proteins which have the same functions with GDF5. You can find most of the proteins on our site.
Function
Related Protein
Function BMP binding
Related Protein HFE2; GDF5; NBL1; BMPR2; TCAP; GREM1; CER1; GREM2
Function cytokine activity
Related Protein GM13288; SLURP1; IL12BA; GDF6; HMGB1B; LTB; IFNA1; CMTM2B; IL15L; CCL4
Function growth factor activity
Related Protein NENF; TFF1; PDGFA; KLK1B4; HBEGF; IL4; JAG2; INHBE; IL5; TYMP
Function identical protein binding
Related Protein AIRE; TLR3; THBS1; TRIM5; SH3GLB1; TMEM173; NDC80; INS; HSP90AA1; TRADD
Function protein binding
Related Protein RAB11B; TRAF4; KLK4; CCDC121; GPBP1; APOBEC2B; EHD3; GNS; RAPGEF6; OOEP
Function transforming growth factor beta receptor binding
Related Protein BMP7B; TGFB2; NDR1; MSTN; LFT2; TGFB1A; GDF2; LFT1; GDF9; SMURF2

Interacting Protein

GDF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF5.
BMPR1B; BMPR1A; NOG; BMPR2

GDF5 Related Articles

Degenkolbe, E; Schwarz, C; et al. Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome. BONE 73:111-119(2015).
Yamashita, A; Morioka, M; et al. Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs. STEM CELL REPORTS 4:404-418(2015).

GDF5 Related Gene Family

TGF