GDF5

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GDF5

Official Full Name growth differentiation factor 5
Background The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.
Synonyms GDF5; growth differentiation factor 5; growth/differentiation factor 5; BMP14; cartilage derived morphogenetic protein 1; CDMP1; GDF-5; CDMP-1; radotermin; cartilage-derived morphogenetic protein-1; OS5; LAP4; SYNS2
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GDF5-049H Recombinant Human GDF5 Protein E. coli
    Human GDF5-13211H Recombinant Human GDF5, GST-tagged E.coli GST
    Human GDF5-27470TH Recombinant Human GDF5 E.coli N/A
    Human GDF5-275H Recombinant Human GDF5 Protein, His-tagged E.coli His
    Human GDF5-27678TH Recombinant Human GDF5, His-tagged E.coli His
    Human GDF-5300H Recombinant Human Growth Differentiation Factor 5, His-tagged E.coli His
    Human GDF5-34H Recombinant Human GDF5 protein E.coli N/A
    Human GDF5-4827H Recombinant Human GDF5 Protein, GST-tagged Wheat Germ GST
    Human GDF5-5968HCL Recombinant Human GDF5 293 Cell Lysate HEK293 N/A
    Mouse Gdf5-065M Recombinant Mouse Gdf5 Protein E.coli
    Mouse Gdf5-276M Recombinant Mouse Gdf5 Protein, His-tagged E.coli His
    Mouse Gdf5-512M Recombinant Mouse Gdf5 protein, His-tagged E.coli His
    Mouse GDF5-6288M Recombinant Mouse GDF5 Protein Mammalian Cell His
    Mouse Gdf5-651M Recombinant Mouse Gdf5 protein E.coli N/A
    Mouse Gdf5-720M Recombinant Mouse Growth Differentiation Factor 5 E.coli N/A
    Mouse Gdf5-7211M Recombinant Mouse Gdf5 Protein, His-tagged E.coli His
    Rat GDF5-320R Recombinant Rat GDF5, His-tagged E. coli His
    Chicken GDF5-5910C Recombinant Chicken GDF5 Mammalian Cell His

    GDF5 involved in several pathways and played different roles in them. We selected most pathways GDF5 participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL25; CCR6A; IFNA13; CXCL8; KITLG; Ifnlr1; NGFR; CXCL14; CXCR4; CD40
    TGF-beta signaling pathway LTBP1; BMP4; FSTA; RPS6KB1; SMAD6; CUL1A; SMAD4; NOG; RHOAA; GDF5
    Hippo signaling pathway AJUBA; PPP2R2D; STK3; TEAD4; FZD7; PRKCZ; SAV1; WNT11; FZD5; Fzd4

    GDF5 has several biochemical functions, for example, BMP binding, cytokine activity, growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF5 itself. We selected most functions GDF5 had, and list some proteins which have the same functions with GDF5. You can find most of the proteins on our site.

    Function Related Protein
    BMP binding CER1; BMPR2; GDF5; GREM2; TCAP; NBL1; GREM1; HFE2
    cytokine activity TNFSF12; TNFSF14; Cxcl15; INHBAB; TGFB1A; IFNA12; MSTNB; SP100; GDF6; GM13285
    growth factor activity FGF12B; FGF21; CLEC11A; MANF; INHBC; BTC; GDF2; HBEGFA; ANGPTL3; GDF7
    identical protein binding CRYBB2; ASS1; LRRK2; ZNF3; BIRC5; LDHA; CALHM1; GRIK5; CLDN16; KHDRBS1
    protein binding ITGA2B; XRCC5; MAPK8; UBE2E3; P2RY6; PPFIA2; KLC4; SERPINA3; RLN3; NRF1
    transforming growth factor beta receptor binding GDF7; TGFBRAP1; INHBA; LEFTY2; LRG1; MSTN; INHBAA; LEFTY1; LFT2; FKBP1A

    GDF5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF5 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF5.

    BMPR1B; BMPR1A; NOG; BMPR2

    Degenkolbe, E; Schwarz, C; et al. Improved bone defect healing by a superagonistic GDF5 variant derived from a patient with multiple synostoses syndrome. BONE 73:111-119(2015).
    Yamashita, A; Morioka, M; et al. Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs. STEM CELL REPORTS 4:404-418(2015).

    TGF

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