|Official Full Name||GDNF family receptor alpha 1|
|Background||Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.|
|Synonyms||GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; GDNF R; GDNF receptor alpha; GDNFR alpha; GDNFRalpha; GFR-ALPHA-1; GFRalpha1; Glial cell line-derived neurotrophic factor receptor alpha; GPI linked anchor protein; GPI-linked anchor protein; MGC23045; PI linked cell surface accessory protein; RET ligand 1; TGF-beta related neurotrophic factor receptor 1; TRNR 1; GDNFR-alpha-1; OTTHUMP00000020558; OTTHUMP00000020559; OTTHUMP00000020560; GDNF receptor alpha-1; PI-linked cell-surface accessory protein; TGF-beta-related neurotrophic factor receptor 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
gfra1 involved in several pathways and played different roles in them. We selected most pathways gfra1 participated on our site, such as Axon guidance, Developmental Biology, Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with gfra1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Axon guidance||JAK3; FES; MYL12A; FGF18B; SRGAP3; CHL1; EFNB3; NRP2; PAQR3A; GNAI1|
|Developmental Biology||KLB; EZRA; SPTA1; ACTR2B; MED26; SALL4; MED20; CLTC; MED7; TRIO|
|Diurnally regulated genes with circadian orthologs||G0S2; KLF9; SF3A3; CBX3; ITM2B; CRY1; QKI; GFRA1; MYF6; AZIN1|
|NCAM signaling for neurite out-growth||GFRA4; GFRA2; GDNF; GFRA1; NRTN; COL9A1B; COL9A1A; ST8SIA2; PSPN|
|NCAM1 interactions||NRTN; GDNF; GFRA2; COL9A1B; GFRA1; GFRA4; PSPN; COL9A1A|
|Signaling events regulated by Ret tyrosine kinase||GFRA1; DOK5; GDNF; DOK6; DOK4; PDLIM7|
gfra1 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by gfra1 itself. We selected most functions gfra1 had, and list some proteins which have the same functions with gfra1. You can find most of the proteins on our site.
|glial cell-derived neurotrophic factor receptor activity||GFRA4; GFRA1; GFRA2|
|receptor binding||FGF12A; HTT; ANXA1; ANGPTL2; CRTAM; WNT2BB; GCG; PVRL1B; WNT7A; PVR|
gfra1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gfra1 here. Most of them are supplied by our site. Hope this information will be useful for your research of gfra1.