GFRA1

  • Official Full Name

    GDNF family receptor alpha 1

  • Overview

    Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
  • Synonyms

    GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; GDNF R; GDNF receptor alpha; GDNFR alpha; GDNFRalpha; GFR-ALPHA-1; GFRalpha1; Glial cell line-derived neurotrophic factor receptor alpha; GPI linked anchor protein; GPI-linked anchor protein; MGC23045; PI linked cell surface accessory protein; RET ligand 1; TGF-beta related neurotrophic factor receptor 1; TRNR 1; GDNFR-alpha-1; OTTHUMP00000020558; OTTHUMP00000020559; OTTHUMP00000020560; GDNF receptor alpha-1; PI-linked cell-surface accessory protein; TGF-beta-related neurotrophic factor receptor 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • Fc
  • His
  • Fc|His
  • GST
  • hFc
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GFRA1-832H Active Recombinant Human GFRA1 Protein, Fc Chimera Mammalian cells Fc
Human GFRA1-3161H Recombinant Human GFRA1 protein, His-tagged HEK293 His
Human GFRA1-3162H Active Recombinant Human GFRA1 protein, hFc-tagged HEK293 hFc
Human GFRA1-712H Recombinant Human GFRA1 Protein, His-tagged CHO His
Human GFRA1-2426HCL Recombinant Human GFRA1 cell lysate Human Cell N/A
Human GFRA1-1854H Recombinant Human GFRA1 protein, His-tagged E.coli His
Human GFRA1-1312H Recombinant Human GFRA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GFRA1-264H Recombinant Human GFRA1 Protein, His-tagged HEK293 His
Human GFRA1-2790H Recombinant Human GFRA1 Protein (Asp25-Ser429), C-Fc tagged Mammalian cells C-Fc
Human GFRA1-3609H Recombinant Human GFRA1 protein, His-tagged E.coli His
Human GFRA1-5439HF Recombinant Full Length Human GFRA1 Protein, GST-tagged In Vitro Cell Free System GST
Human GFRA1-4860H Recombinant Human GFRA1 Protein, GST-tagged Wheat Germ GST
Human GFRA1-01H Recombinant Human GFRA1 Protein, C-Fc-tagged Human Cell Fc
Human GFRA1-2040H Recombinant Human GFRA1 Protein, Fc/His-tagged HEK293 Fc/His
Human GFRA1-265H Recombinant Human GFRA1 Protein, Fc-tagged HEK293 Fc
Human GFRA1-11H Recombinant Human GFRA1 protein, His-tagged HEK293 His
Human GFRA1-2633H Active Recombinant Human GFRA1 protein, hFc&His-tagged HEK293 hFc&His
Human GFRA1-80H Recombinant Human GFRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human GFRA1-80H-B Recombinant Human GFRA1 Protein Pre-coupled Magnetic Beads HEK293
Human GFRA1-2168H Active Recombinant Human GFRA1 protein, His-tagged HEK293 His
Mouse Gfra1-722M Recombinant Mouse Gfra1, His tagged Human Cell His
Mouse GFRA1-2692MCL Recombinant Mouse GFRA1 cell lysate Human Cell N/A
Mouse Gfra1-5015M Recombinant Mouse Gfra1 protein, His-tagged HEK293 His
Mouse Gfra1-1855M Recombinant Mouse Gfra1 protein, His & GST-tagged E.coli His/GST
Mouse Gfra1-3197M Recombinant Mouse Gfra1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Gfra1-4085R Active Recombinant Rat Gfra1 protein(Met1-Leu445), His-tagged HEK293 C-His
Rat GFRA1-293R Recombinant Rat Gfra1, Fc tagged Human Cell His
Rat GFRA1-2514R Recombinant Rat GFRA1 Protein Mammalian Cell His
Rat GFRA1-961RCL Recombinant Rat GFRA1 cell lysate Human Cell N/A
Rat GFRA1-2170R-B Recombinant Rat GFRA1 Protein Pre-coupled Magnetic Beads HEK293
Rat GFRA1-2170R Recombinant Rat GFRA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Canine GFRA1-298C Recombinant Canine GFRA1, His tagged Human Cell His
Canine GFRA1-966CCL Recombinant Canine GFRA1 cell lysate Human Cell N/A
Chicken GFRA1-6659C Recombinant Chicken GFRA1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GFRA1 Related Articles
  • GFRA1 Related Gene Family
  • GFRA1 Related Research Area

GFRA1 involved in several pathways and played different roles in them. We selected most pathways GFRA1 participated on our site, such as Axon guidance, Developmental Biology, Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceGFRA1;RGMA;ADAM10;ARPC5;DPYSL5;NTN1B;UNC5A;UNC5D;SLIT2
Developmental BiologySCN9A;MED15;TRIO;TCF3B;TCF3A;RHOGA;CFL1;TRPC7;NTN1B
Diurnally regulated genes with circadian orthologsTOB1;AZIN1;CEBPB;RBPMS;EIF4G2;ZFR;DAZAP2;MYF6;STBD1
NCAM signaling for neurite out-growthGDNF;GFRA4;GFRA2;PSPN;GFRA1;COL9A1B;ST8SIA2;COL9A1A;NRTN
NCAM1 interactionsCOL9A1B;GDNF;COL9A1A;GFRA4;PSPN;NRTN;GFRA1;GFRA2
Signaling events regulated by Ret tyrosine kinaseDOK5;DOK4;GFRA1;DOK6;GDNF;PDLIM7

GFRA1 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA1 itself. We selected most functions GFRA1 had, and list some proteins which have the same functions with GFRA1. You can find most of the proteins on our site.

Function Related Protein
glial cell-derived neurotrophic factor receptor activityGFRA4;GFRA2;GFRA1
receptor bindingNRG2A;F2RL1;GFRA1;WNT4A;GIPC1;TNFSF14;FGF11A;CXADR;ADCYAP1

GFRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFRA1.

SOCS3

Takashima, S; Kanatsu-Shinohara, M; et al. Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal. STEM CELL REPORTS 4:489-502(2015).
Hettige, NC; Zai, C; et al. Use of candidate gene markers to guide antipsychotic dosage adjustment. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 54:315-320(2014).
TGF
  • Q&As
  • Reviews

Q&As (5)

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Are there any ongoing clinical trials targeting GFRA1 for neurodegenerative diseases? 05/25/2021

Yes, several clinical trials are exploring the modulation of GFRA1 for the treatment of neurodegenerative diseases.

How does GFRA1 contribute to neuroprotection? 04/25/2020

GFRA1 is involved in neuroprotection by promoting the survival and maintenance of neurons, making it a potential target for therapeutic interventions.

How does GFRA1 influence the development and function of the nervous system? 10/10/2017

GFRA1 is crucial for the development and function of the nervous system as it participates in the regulation of neuronal survival and differentiation.

Are there any therapeutic strategies targeting GFRA1 for neuroregeneration? 10/26/2016

Some therapeutic strategies aim to harness GFRA1 for promoting neuroregeneration, especially in the context of nerve injuries.

Can GFRA1 protein be a biomarker for certain neurological disorders? 07/12/2016

Research suggests that alterations in GFRA1 expression may serve as a potential biomarker for specific neurological disorders.

Customer Reviews (3)

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Reviews
03/24/2022

    With their expertise, I can navigate through experimental hurdles, optimize protocols, and ensure the seamless integration of the GFRA1 protein into my investigations.

    08/19/2020

      The GFRA1 protein showcases unparalleled quality, ensuring it surpasses expectations and satisfactorily addresses my experimental requirements.

      03/11/2020

        Their knowledgeable and responsive team stands ready to address any concerns or challenges I may encounter.

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