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Official Full Name GDNF family receptor alpha 1
Background Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene.
Synonyms GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; GDNF R; GDNF receptor alpha; GDNFR alpha; GDNFRalpha; GFR-ALPHA-1; GFRalpha1; Glial cell line-derived neurotrophic factor receptor alpha; GPI linked anchor protein; GPI-linked anchor protein; MGC23045; PI linked cell surface accessory protein; RET ligand 1; TGF-beta related neurotrophic factor receptor 1; TRNR 1; GDNFR-alpha-1; OTTHUMP00000020558; OTTHUMP00000020559; OTTHUMP00000020560; GDNF receptor alpha-1; PI-linked cell-surface accessory protein; TGF-beta-related neurotrophic factor receptor 1
    • Species :
    • Canine
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • human
    • IgG1
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GFRA1-1312H Recombinant Human GFRA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GFRA1-1854H Recombinant Human GFRA1 protein, His-tagged E.coli His
    Human GFRA1-2040H Recombinant Human GFRA1 Protein, Fc/His-tagged HEK293 Fc/His
    Human GFRA1-2426HCL Recombinant Human GFRA1 cell lysate Human Cell N/A
    Human GFRA1-3161H Recombinant Human GFRA1 protein, His-tagged HEK293 His
    Human GFRA1-3162H Recombinant Human GFRA1 protein, Fc-tagged HEK293 human/IgG1/Fc
    Human GFRA1-4860H Recombinant Human GFRA1 Protein, GST-tagged Wheat Germ GST
    Human GFRA1-712H Recombinant Human GFRA1 Protein, His-tagged CHO His
    Human GFRA1-832H Recombinant Human GFRA1 Protein, Fc Chimera Mammalian cells Fc
    Mouse Gfra1-1855M Recombinant Mouse Gfra1 protein, His & GST-tagged E.coli His/GST
    Mouse GFRA1-2692MCL Recombinant Mouse GFRA1 cell lysate Human Cell N/A
    Mouse Gfra1-3197M Recombinant Mouse Gfra1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Gfra1-722M Recombinant Mouse Gfra1, His tagged Human Cell His
    Rat GFRA1-2514R Recombinant Rat GFRA1 Protein Mammalian Cell His
    Rat GFRA1-293R Recombinant Rat Gfra1, Fc tagged Human Cell His
    Rat Gfra1-4085R Recombinant Rat Gfra1, His tagged Human Cell His
    Rat GFRA1-961RCL Recombinant Rat GFRA1 cell lysate Human Cell N/A
    Canine GFRA1-298C Recombinant Canine GFRA1, His tagged Human Cell His
    Canine GFRA1-966CCL Recombinant Canine GFRA1 cell lysate Human Cell N/A
    Chicken GFRA1-6659C Recombinant Chicken GFRA1 Mammalian Cell His

    gfra1 involved in several pathways and played different roles in them. We selected most pathways gfra1 participated on our site, such as Axon guidance, Developmental Biology, Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with gfra1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance JAK3; FES; MYL12A; FGF18B; SRGAP3; CHL1; EFNB3; NRP2; PAQR3A; GNAI1
    Developmental Biology KLB; EZRA; SPTA1; ACTR2B; MED26; SALL4; MED20; CLTC; MED7; TRIO
    Diurnally regulated genes with circadian orthologs G0S2; KLF9; SF3A3; CBX3; ITM2B; CRY1; QKI; GFRA1; MYF6; AZIN1
    NCAM signaling for neurite out-growth GFRA4; GFRA2; GDNF; GFRA1; NRTN; COL9A1B; COL9A1A; ST8SIA2; PSPN
    NCAM1 interactions NRTN; GDNF; GFRA2; COL9A1B; GFRA1; GFRA4; PSPN; COL9A1A
    Signaling events regulated by Ret tyrosine kinase GFRA1; DOK5; GDNF; DOK6; DOK4; PDLIM7

    gfra1 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by gfra1 itself. We selected most functions gfra1 had, and list some proteins which have the same functions with gfra1. You can find most of the proteins on our site.

    Function Related Protein
    glial cell-derived neurotrophic factor receptor activity GFRA4; GFRA1; GFRA2
    receptor binding FGF12A; HTT; ANXA1; ANGPTL2; CRTAM; WNT2BB; GCG; PVRL1B; WNT7A; PVR

    gfra1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gfra1 here. Most of them are supplied by our site. Hope this information will be useful for your research of gfra1.


    Takashima, S; Kanatsu-Shinohara, M; et al. Functional Differences between GDNF-Dependent and FGF2-Dependent Mouse Spermatogonial Stem Cell Self-Renewal. STEM CELL REPORTS 4:489-502(2015).
    Hettige, NC; Zai, C; et al. Use of candidate gene markers to guide antipsychotic dosage adjustment. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY 54:315-320(2014).


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