GFRA1
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Official Full Name
GDNF family receptor alpha 1
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Overview
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. -
Synonyms
GFRA1; GDNF family receptor alpha 1; GDNFRA; GDNF family receptor alpha-1; GDNFR; GFR ALPHA 1; RET1L; RETL1; TRNR1; GDNF R; GDNF receptor alpha; GDNFR alpha; GDNFRalpha; GFR-ALPHA-1; GFRalpha1; Glial cell line-derived neurotrophic factor receptor alpha; GPI linked anchor protein; GPI-linked anchor protein; MGC23045; PI linked cell surface accessory protein; RET ligand 1; TGF-beta related neurotrophic factor receptor 1; TRNR 1; GDNFR-alpha-1; OTTHUMP00000020558; OTTHUMP00000020559; OTTHUMP00000020560; GDNF receptor alpha-1; PI-linked cell-surface accessory protein; TGF-beta-related neurotrophic factor receptor 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Canine
- Chicken
- Human
- Mouse
- Rat
- CHO
- E. coli
- E.coli
- HEK293
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- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- Fc
- Fc|His
- GST
- hFc
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- GFRA1 Related Articles
- GFRA1 Related Gene Family
- GFRA1 Related Research Area
GFRA1 involved in several pathways and played different roles in them. We selected most pathways GFRA1 participated on our site, such as Axon guidance, Developmental Biology, Diurnally regulated genes with circadian orthologs, which may be useful for your reference. Also, other proteins which involved in the same pathway with GFRA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | WDR83;CRMP1;ABL1;SPRED2;FRS2;EFNA1B;NCK2;SRGAP3;SPTBN2 |
| Developmental Biology | JAK1;FGF10B;FRS2B;TCF3B;TRPC5;AP2A2;TRPC4;KLB;PAQR3B |
| Diurnally regulated genes with circadian orthologs | CBX3;RBPMS;CRY1;EIF4G2;AZIN1;GFRA1;TOB1;KLF9;NR1D2 |
| NCAM signaling for neurite out-growth | COL9A1B;NRTN;GFRA4;GDNF;GFRA2;COL9A1A;ST8SIA2;GFRA1;PSPN |
| NCAM1 interactions | NRTN;GDNF;PSPN;GFRA4;GFRA2;COL9A1A;GFRA1;COL9A1B |
| Signaling events regulated by Ret tyrosine kinase | GDNF;PDLIM7;DOK5;DOK6;DOK4;GFRA1 |
GFRA1 has several biochemical functions, for example, glial cell-derived neurotrophic factor receptor activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GFRA1 itself. We selected most functions GFRA1 had, and list some proteins which have the same functions with GFRA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glial cell-derived neurotrophic factor receptor activity | GFRA2;GFRA1;GFRA4 |
| receptor binding | TNFSF8;HLA-E;REN;ANXA1;TNFSF13;HLA-G;HLA-F;GUSB;Itga10&Itgb1 |
GFRA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GFRA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GFRA1.
SOCS3
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, several clinical trials are exploring the modulation of GFRA1 for the treatment of neurodegenerative diseases.
GFRA1 is involved in neuroprotection by promoting the survival and maintenance of neurons, making it a potential target for therapeutic interventions.
GFRA1 is crucial for the development and function of the nervous system as it participates in the regulation of neuronal survival and differentiation.
Some therapeutic strategies aim to harness GFRA1 for promoting neuroregeneration, especially in the context of nerve injuries.
Research suggests that alterations in GFRA1 expression may serve as a potential biomarker for specific neurological disorders.
Customer Reviews (3)
Write a reviewWith their expertise, I can navigate through experimental hurdles, optimize protocols, and ensure the seamless integration of the GFRA1 protein into my investigations.
The GFRA1 protein showcases unparalleled quality, ensuring it surpasses expectations and satisfactorily addresses my experimental requirements.
Their knowledgeable and responsive team stands ready to address any concerns or challenges I may encounter.
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