GPX1

  • Official Full Name

    glutathione peroxidase 1

  • Overview

    Glutathione peroxidase 1 (GPX1) is a cytosolic selenoprotein which reduces hydrogen peroxide to water. GPX1 is the most abundant and ubiquitous among the five GPX isoforms identified so far. It is an important component in the anti-oxidative defense in ce
  • Synonyms

    GPX1; glutathione peroxidase 1; GPx-1; GSHPx-1; cellular glutathione peroxidase; GPXD; GSHPX1; MGC14399; MGC88245;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • Erythrocytes
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GPX1-1273H Recombinant Human Glutathione Peroxidase 1, His-tagged Human His
Human GPX1-29074TH Recombinant Human GPX1, His-tagged E.coli His
Human GPX1-29073TH Recombinant Human GPX1, His-tagged E.coli His
Human GPX1-5763HCL Recombinant Human GPX1 293 Cell Lysate HEK293 N/A
Human GPX1-8429H Native Human GPX1 Erythrocytes N/A
Human GPX1-2990H Recombinant Human GPX1 protein, His-SUMO-tagged E.coli His-SUMO
Human GPX1-5308H Recombinant Human GPX1 Protein, GST-tagged Wheat Germ GST
Human GPX1-2469H Recombinant Human GPX1 Protein (Thr50-Ala202), N-His tagged E.coli N-His
Human GPX1-5307H Recombinant Human GPX1 Protein, His-tagged E.coli His
Human GPX1-2470H Recombinant Human GPX1 Protein (Thr50-Ala203), His tagged E.coli His
Human GPX1-5579HF Recombinant Full Length Human GPX1 Protein, GST-tagged In Vitro Cell Free System GST
Human GPX1-22H Recombinant Human GPX1 Protein Tag Free
Mouse GPX1-7230M Recombinant Mouse GPX1 Protein Mammalian Cell His
Mouse GPX1-3901M Recombinant Mouse GPX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Gpx1-1584M Recombinant Mouse Gpx1 Protein, His&GST-tagged E.coli N-His&GST
Mouse GPX1-3901M-B Recombinant Mouse GPX1 Protein Pre-coupled Magnetic Beads HEK293
Rat GPX1-2677R Recombinant Rat GPX1 Protein Mammalian Cell His
Rat GPX1-2331R-B Recombinant Rat GPX1 Protein Pre-coupled Magnetic Beads HEK293
Rat GPX1-2331R Recombinant Rat GPX1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Gpx1-1585R Recombinant Rat Gpx1 Protein, His-tagged E.coli N-His
Chicken GPX1-5202C Recombinant Chicken GPX1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GPX1 Related Articles
  • GPX1 Related Research Area

GPX1 involved in several pathways and played different roles in them. We selected most pathways GPX1 participated on our site, such as Glutathione metabolism, Arachidonic acid metabolism, Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glutathione metabolismGSTM2;GPX6;GSTT1B;GGCT;SRM;GSTA3;GPX5;RRM2B;MGST1.2
Arachidonic acid metabolismPTGDSB;PLA2G2F;DPEP2;GPX7;PLA2G2A;CYP2C54;ALOX5A;GPX2;ALOX12E
Thyroid hormone synthesisDUOX2;ATP1B4;PRKCB;TTF2;ATP1A1;ITPR1;PRKCA;GPX1;PLCB3
Amyotrophic lateral sclerosis (ALS)BID;SOD1;CAT;NOS1;DAXX;GPX1;CCS;PPP3R1;TRP53
Huntingtons diseaseDNAH14;DNALC1;UQCR10;GRM5;NDUFV1;NDUFA5;COX8A;NDUFV3;POLR2I

GPX1 has several biochemical functions, for example, SH3 domain binding, glutathione binding, glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX1 itself. We selected most functions GPX1 had, and list some proteins which have the same functions with GPX1. You can find most of the proteins on our site.

Function Related Protein
SH3 domain bindingEVL;DNM2;CABYR;DRD4;SH3BP5LA;EFS;PTTG2;KHDRBS1;ADAM10
glutathione bindingGPX1;PTGES;PTGESL;MGST1;GSTM7;GSTM2;GSTP2;GSS;PTGES2
glutathione peroxidase activityGPX1;GPX6;GSTT1;GSTZ1;GPX8;GPX4A;GPX3;GPX1A;GPX7
phospholipid-hydroperoxide glutathione peroxidase activityGPX1;GPX4
selenium bindingDIO2;SEPP1;GPX3;GPX1;SEP15;RPH3A;SELT;DIO1;SELENBP2

GPX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX1.

glutathione; fumaric acid; MAPK6; SIRT4

Guo, X; Yu, Y; et al. Heterologous expression and characterization of human cellular glutathione peroxidase mutants. IUBMB LIFE 66:212-219(2014).
Zemolin, APP; Meinerz, DF; et al. Evidences for a role of glutathione peroxidase 4 (GPx4) in methylmercury induced neurotoxicity in vivo. TOXICOLOGY 302:60-67(2012).
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