GRB7 Protein


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Official Full Name growth factor receptor-bound protein 7
Background The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.
Synonyms GRB7; growth factor receptor-bound protein 7; B47; Epidermal growth factor receptor GRB 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7_HUMAN; Growth factor receptor bound protein 7; OTTHUMP00000164349; OTTHUMP00000164350; OTTHUMP00000164351; OTTHUMP00000164352
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GRB7-13521H Recombinant Human GRB7, His-tagged E.coli His
    Human GRB7-27926TH Recombinant Human GRB7 Wheat Germ N/A
    Human GRB7-4848H Recombinant Human Growth Factor Receptor-Bound Protein 7, GST-tagged E.coli GST
    Human GRB7-6971H Recombinant Human GRB7, GST-tagged E.coli GST
    Mouse GRB7-7247M Recombinant Mouse GRB7 Protein Mammalian Cell His
    Rat GRB7-2687R Recombinant Rat GRB7 Protein Mammalian Cell His
    Human GRB7-5754HCL Recombinant Human GRB7 293 Cell Lysate HEK293 N/A
    Human GRB7-247H Recombinant Human GRB7 Protein, His-tagged E.coli His
    Human GRB7-5316H Recombinant Human GRB7 Protein, GST-tagged Wheat Germ GST
    Human GRB7-5680H Recombinant Human GRB7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Grb7-1055M Recombinant Mouse Grb7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Grb7-248M Recombinant Mouse Grb7 Protein, His-tagged E.coli His

    GRB7 involved in several pathways and played different roles in them. We selected most pathways GRB7 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Cell surface interactions at the vascular wall, Downstream signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Angiopoietin receptor Tie2-mediated signaling CRK; ELF2; GRB7; ELF1; DOK2; AGTR1; CDKN1A; BMX; GRB14
    Cell surface interactions at the vascular wall CEACAM8; CD84; SIRPA; F11R.2; JAM2B; SLC7A11; SLC7A6; TREM1; PPIA; CXADR
    Downstream signal transduction CRKL; SPTBN2; SPTB; DUSP9; PEA15; AGO3; SPRED3; RASGEF1A; FRS2A; PAQR3A
    EGFR1 Signaling Pathway ZPR1; ZFP259; ABI1; WNK1; SH3BGRL; GRB14; CRKL; GRB10; USP6NL; PLSCR1
    EPHB forward signaling EFNB3; EFNB2; EFNB1; EFNA5; GRB7; ITSN1
    GRB7 events in ERBB2 signaling GRB7
    Hemostasis KIFC1; HBG1; KIF2B; SLC16A1; CFHL3; HMG20B; DOCK2; CFHL1; SLC16A8; ANGPT2A
    Kit Receptor Signaling Pathway GRAPA; PTPRUB; DOK1B; GRAP; DOK1; STAP1; GRB10; PTPRU; SOCS4; SPRED2B

    GRB7 has several biochemical functions, for example, RNA binding, SH3/SH2 adaptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB7 itself. We selected most functions GRB7 had, and list some proteins which have the same functions with GRB7. You can find most of the proteins on our site.

    Function Related Protein
    SH3/SH2 adaptor activity GRB2; GAB1; SH2D2A; STAP1; SH2D3A; NCK2; SLA2; CHN2; PAG1; SOCS2
    identical protein binding IMPA1; SNRNP200; TMEM173; JMJD6; ETNPPL; MAP3K13; MTPAP; MYBPC3; VWA2; BTK
    phosphatidylinositol binding TNFAIP8L3; SNX10A; SNX29; SNX27B; SNX8; SNX1B; PASK; SH3PXD2AA; PIK3C2B; SNX16
    protein binding MMRN2; HSPA6; THOC2; HLA-DRB4; FABP3; RAB39B; PSMA2; SLC6A20B; KCNB1; BBOX1
    protein kinase binding Cd24a; AGTR1A; TEX14; IKBKB; SMAD1; LIMS1; TRIM6; FGR; FAM83D; EEF1A1

    GRB7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB7.


    Murray, JC; Aldeghaither, D; et al. c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1186-1198(2014).
    Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).


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