GRB7

  • Official Full Name

    growth factor receptor-bound protein 7

  • Overview

    The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene.
  • Synonyms

    GRB7; growth factor receptor-bound protein 7; B47; Epidermal growth factor receptor GRB 7; Epidermal growth factor receptor GRB-7; GRB7 adapter protein; GRB7_HUMAN; Growth factor receptor bound protein 7; OTTHUMP00000164349; OTTHUMP00000164350; OTTHUMP00000164351; OTTHUMP00000164352;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GRB7-4848H Recombinant Human Growth Factor Receptor-Bound Protein 7, GST-tagged E.coli GST
Human GRB7-13521H Recombinant Human GRB7, His-tagged E.coli His 184-532a.a.
Human GRB7-27926TH Recombinant Human GRB7 Wheat Germ N/A 532 amino acids
Human GRB7-6971H Recombinant Human GRB7, GST-tagged E.coli GST Full length
Human GRB7-5754HCL Recombinant Human GRB7 293 Cell Lysate HEK293 N/A
Human GRB7-247H Recombinant Human GRB7 Protein, His-tagged E.coli His Ser66~Thr327
Human GRB7-5316H Recombinant Human GRB7 Protein, GST-tagged Wheat Germ GST
Human GRB7-5591HF Recombinant Full Length Human GRB7 Protein, GST-tagged In Vitro Cell Free System GST 532 amino acids
Human GRB7-2649H Recombinant Human GRB7 Protein (Ser66-Thr327), His tagged E.coli His Ser66-Thr327
Human GRB7-5680H Recombinant Human GRB7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human GRB7-206HF Recombinant Full Length Human GRB7 Protein In Vitro Cell Free System 532 amino acids
Mouse GRB7-7247M Recombinant Mouse GRB7 Protein Mammalian Cell His
Mouse GRB7-3914M Recombinant Mouse GRB7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Grb7-1055M Recombinant Mouse Grb7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Grb7-248M Recombinant Mouse Grb7 Protein, His-tagged E.coli His Met298~Glu489
Mouse GRB7-3914M-B Recombinant Mouse GRB7 Protein Pre-coupled Magnetic Beads HEK293
Rat GRB7-2687R Recombinant Rat GRB7 Protein Mammalian Cell His
Rat GRB7-2341R Recombinant Rat GRB7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GRB7-2341R-B Recombinant Rat GRB7 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • GRB7 Related Signal Pathway

GRB7 involved in several pathways and played different roles in them. We selected most pathways GRB7 participated on our site, such as Angiopoietin receptor Tie2-mediated signaling, Cell surface interactions at the vascular wall, Downstream signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRB7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Angiopoietin receptor Tie2-mediated signalingBMX;DOK2;CDKN1A;ELF2;ELF1;AGTR1;CRK;GRB14;GRB7
Cell surface interactions at the vascular wallSLC7A8A;CD84;FCER1GL;BSG;NADL1.1;F11R.2;MERTK;PROCR;JAM2B
Downstream signal transductionSPRED1;FRS3;GRB7;DUSP10;CNKSR1;IL17RD;DAB2IPB;FGF8B;DUSP7
EGFR1 Signaling PathwayRALBB;PLSCR1;KRT8;ZFP259;CEBPA;REPS2;JUND;ZPR1;SPRY2
EPHB forward signalingEFNB2;EFNB3;GRB7;EFNA5;ITSN1;EFNB1
GRB7 events in ERBB2 signaling
HemostasisBSG;DGKQ;PLEK;SLC3A2A;DOCK6;Alb;SH2B3;SLC7A6;TRPC3
Kit Receptor Signaling PathwayPTPRUB;DOK1;DOK1B;GRAPA;PTPRU;GRB7;SPRED2B;GRAP;SOCS4

GRB7 has several biochemical functions, for example, RNA binding, SH3/SH2 adaptor activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GRB7 itself. We selected most functions GRB7 had, and list some proteins which have the same functions with GRB7. You can find most of the proteins on our site.

Function Related Protein
RNA bindingDCP2;DDX19B;EWSR1;NABP1;PES;UPF1;THUMPD3;RBMS3;AGFG1
SH3/SH2 adaptor activitySH3BP2;TOB1;EPS8;SH2D3C;SRC;SKAP1;CNTNAP1;NCK1;SLA2
identical protein bindingGYPA;SORD;SHMT2;BIRC5;DACT3;FUS;PIK3AP1;AIM2;CSNK2B
phosphatidylinositol bindingCCDC88A;SNX17;RPS6KC1;SNX2;SNX1A;SNX1B;SNX27;TUB;ARHGAP33
protein bindingPCDHA4;WHSC1L1;Ccl27a;RECQL;USP47;EXOC8;DCUN1D4;SELE;PYGO1
protein kinase bindingTP73;FGF19;GATA4;SMAD1;EEF2;GRB2;C10orf46;RICTOR;LATS1

GRB7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRB7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRB7.

ERBB2; ERBB3; KIT; RND1

Gene Family

TGF

Research Area

Related articles

Murray, JC; Aldeghaither, D; et al. c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity. CANCER IMMUNOLOGY RESEARCH 2:1186-1198(2014).
Pogue-Geile, KL; Kim, C; et al. Predicting Degree of Benefit From Adjuvant Trastuzumab in NSABP Trial B-31. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE 105:1782-1788(2013).
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