GRIN2A
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Official Full Name
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
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Overview
The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function. The NMDAR is a specific type of ionotropic glutamate receptor. NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations. A unique property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg2+ ions. This allows the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent. Calcium flux through NMDARs is thought to play a critical role in synaptic plasticity, a cellular mechanism for learning and memory. The NMDA receptor is distinct in two ways: First, it is both ligand-gated and voltage-dependent; second, it requires co-activation by two ligands - glutamate and glycine (Rang et al (July 2010). Pharmacology. pp. 466.). -
Synonyms
Grin2a; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDAR2A; NR2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; OTTHUMP0000016013; OTTHUMP00000174531; glutamate [NMDA] receptor subunit epsilon-1; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA receptor subtype 2A; glutamate receptor, ionotropic, NMDA2A (epsilon1); GluN2A; GluRepsilon1; OTTMUSP00000017426;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- C
- His
- GST
- His (Fc)
- Avi
- N
- Involved Pathway
- Protein Function
- Interacting Protein
GRIN2A involved in several pathways and played different roles in them. We selected most pathways GRIN2A participated on our site, such as Ras signaling pathway, Rap signaling pathway, Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRIN2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ras signaling pathway | GNG7;PAK1;RALB;RASGRP3;FGF3;FGF5;TEK;PAK2;ANGPT1 |
| Rap signaling pathway | RAC1;VASP;PLCG1;FGF6;HRAS;MAGI2;P2RY1;HGF;PLCB1 |
| Calcium signaling pathway | PPIAA;ATP2B3B;CHRM1;NOS2A;CACNA1D;GRM1;GNAQ;GNA15.1;CALM4 |
| cAMP signaling pathway | GNAI3;RYR2;NPY1R;MC2R;ACOX1;PTGER3;CAMK2A;GLI1;PIK3R2 |
| Neuroactive ligand-receptor interaction | GRIN1B;GRIN2BB;GRIN1A;PTGIR;P2RY14;CHRNB3B;HTR1AB;OPRL1;PRLRA |
| Circadian entrainment | GNG10;PLCB1;PRKCA;GNAS;PER3;GNAI3;CALM1;GRIN1;GNAI2 |
| Long-term potentiation | GRIA1;EP300;PRKCA;PPP1CC;RPS6KA6;CALML5;PRKACB;KRAS;PPP3CA |
| Glutamatergic synapse | SLC17A7;PRKACA;PLA2G4A;GRIN1;GLS;PLA2G4F;ITPR3;PRKACB;GRIN2C |
| Dopaminergic synapse | GRIN2A;CREB3L2;GNB1;GNGT1;KCNJ6;PRKCB;GNB4;GNAO1;GNG12 |
| Alzheimers disease | ATP5G1;NDUFS7;NDUFS2;NDUFV3;ATP5F1;CASP12;SDHB;NDUFA6;COX8A |
| Amyotrophic lateral sclerosis (ALS) | MAPK14;MAP3K5;Casp3;TNFRSF1A;MAPK12;BCL2L1;BCL2;GRIN2C;CAT |
| Cocaine addiction | CDK5;GRIN2D;GRM3;GRIN3B;PDYN;CREB3L2;SLC18A2;DLG4;NFKB1 |
| Nicotine addiction | GRIA3;SLC17A7;GABRA4;GRIN2D;GABRR2;GABRA6;GABRG2;GRIN2C;GABRG1 |
| Alcoholism | GM6026;HIST1H4L;HIST1H2BO;HDAC2;HIST4H4;SOS1;GNG2;CRH;HIST1H2AO |
| Systemic lupus erythematosus | HIST1H2BN;HLA-DPB1;GRIN2B;HIST1H2BB;C8A;HLA-DRB3;SNRPD3;HIST2H3A;HIST2H4A |
GRIN2A has several biochemical functions, for example, ATPase binding, NMDA glutamate receptor activity, contributes_to NMDA glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRIN2A itself. We selected most functions GRIN2A had, and list some proteins which have the same functions with GRIN2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATPase binding | METTL21A;SYVN1;ATP6V0A2;NUFIP1;NSFL1C;ATP6V0A2B;ATP6V1G1;ATP1B3;ATP6V1E1 |
| NMDA glutamate receptor activity | GRIN2B;GRIN2BB;GRIN1A;GRIN2C;GRIN3A;GRIN1B;GRIN3B;GRIN2A;GRIN2D |
| contributes_to NMDA glutamate receptor activity | GRIN3A;PTK2B;GRIN2A;GRIN1 |
| contributes_to calcium channel activity | GRIN3B;GRIN1;GRIN2A |
| calcium channel activity | CACNG8A;ITPR1;RYR1;TRPV2;CACNG1A;UBXN6;GRIN3A;CACNA1SB;MCU |
| cation channel activity | ASIC4B;TRPV2;ASIC1A;TRPC1;P2RX1;CALHM3;ASIC1C;PKD2L1;ASIC4A |
| contributes_to cation channel activity | PKD1L3;GRIN2A |
| cell adhesion molecule binding | CADM2A;NLGN1;CD1d1;PVRL1;PKP3;CRTAM;NRXN1;NLGN4Y;EZR |
| extracellular-glutamate-gated ion channel activity | GRIA4B;GRIK3;KBP;GRID2;GRIK5;GRIA3B;GRIA1A;GRIN2D;GRIN2BB |
| contributes_to extracellular-glutamate-gated ion channel activity | |
| glutamate binding | GRM7;GRIK1;GRIN2A;SLC1A3;GCLC;GLUL;CPS1;GAD2;GRIN1 |
| glutamate receptor binding | PLCG1;GRIN2A;SYNDIG1;CAMK2A;GRIN1 |
| ion channel activity | TRPA1A;TRPC4B;CLCNKB;KCNH2A;TRPC2;FXYD7;KCNC2;P2RX3B;TRPC7A |
| ionotropic glutamate receptor activity | GRIA4;GRIA3B;GRIA4A;GRIN2A;KBP;GRIK3;GRID1;GRIN3B;GRIA3A |
| contributes_to ionotropic glutamate receptor activity | |
| metal ion binding | MKNK2;TGM2B;EYA4;ZBTB7B;ZFP64;ARAP3;RFNG;ZNF543;ZNF703 |
| neurotransmitter binding | GRIN1;GRIN3B;NIPSNAP1;SLC6A13;SLC6A11;GRIN2A |
| protein binding | HNRPLL;SMAD1;MTMR6;EXD1;GLDN;ADAR;UBA2;PDP1;AICDA |
| protein complex binding | C8A;NR0B2;NSF;PCSK2;DRD1;PAFAH1B1;VHLL;Casp3;GRIN2A |
| protein dimerization activity | PRDX5;HNF1BA;NCF4;PPP3CA;DNM1;OLIG1;SCXA;HER4.3;SIM1B |
| protein heterodimerization activity | HIST1H4G;ADRB1;POLA1;UGT1A7;TBX15;ROPN1B;HIST1H2BH;CXCL13;PDSS1 |
| protein kinase binding | AKAP1;USP37;CAMK2N2;NGFRAP1;SMAD3;MAP3K5;C10orf46;B4GALT1;CACNB3 |
| receptor activity | LILRB2;F2RL1.2;THRAP3;IL18RAP;JMJD6;CD160;HTR3A;ICAM1;ITGB4 |
| receptor binding | LHB;WNT11R;FIS1;IDH1;LBP;JAK2;GLA;Fert2;FGF20B |
| scaffold protein binding | NLRP1;CHUK;PDE4D;HOMER1;GRIN2A;VIM;SRC;NOS3;SCN5A |
| voltage-gated cation channel activity | GRIN1;GRIK1;PKD2;GRIN2A;HVCN1 |
| zinc ion binding | VPS11;TRIM35-1;AEBP1;TET2;DNAJC24;FTR43;RBM14B;MKRN1;ADAMTS16 |
GRIN2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRIN2A here. Most of them are supplied by our site. Hope this information will be useful for your research of GRIN2A.
Dlg4; Grin1; Grin2b; Il16; Inadl
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