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Official Full Name histone deacetylase 8
Background Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Synonyms HDAC8; histone deacetylase 8; HD8; WTS; RPD3; CDA07; CDLS5; MRXS6; HDACL1; histone deacetylase-like 1; Wilson-Turner X-linked mental retardation syndrome; Wilson-Turner syndrome (mental retardation, X-linked, syndromic-6, with gynecomastia and obesity);
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293 cells
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Met
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HDAC8-125H Recombinant Human HDAC8 Protein, His-tagged E. coli His
    Human HDAC8-13711H Recombinant Human HDAC8, His-tagged E.coli His
    Human HDAC8-1595H Recombinant Human Histone Deacetylase 8, His-tagged Sf9 Insect Cell His
    Human HDAC8-1655H Recombinant Human Histone Deacetylase 8 Sf9 Insect Cell N/A
    Human HDAC8-26H Recombinant Human HDAC8 Protein, His-tagged E.coli His
    Human HDAC8-27529TH Recombinant Human HDAC8, His-tagged His
    Human HDAC8-314H Recombinant Human HDAC8 Protein HEK293 cells N/A
    Human HDAC8-3331H Recombinant Human HDAC8, GST tagged Insect Cell GST
    Human HDAC8-335H Recombinant Human HDAC8, Met&His-tagged Sf21 Insect Cell Met/His
    Human HDAC8-399H Recombinant Human Histone Deacetylase 8, GST-tagged Insect Cell GST
    Human HDAC8-4650H Recombinant Human HDAC8 Protein, GST-tagged Wheat Germ GST
    Human HDAC8-691HCL Recombinant Human HDAC8 cell lysate Insect Cell N/A
    Human HDAC8-759H Recombinant Human Histone Deacetylase 8, His-tagged S.frugiperda His
    Human HDAC8-99H Recombinant Human HDAC8 Protein, His-tagged Insect Cell His
    Mouse Hdac8-1808M Recombinant Mouse Hdac8, His tagged Insect Cell His
    Mouse HDAC8-537MCL Recombinant Mouse HDAC8 cell lysate Insect Cell N/A
    Rat HDAC8-2818R Recombinant Rat HDAC8 Protein Mammalian Cell His
    Zebrafish HDAC8-12602Z Recombinant Zebrafish HDAC8 Mammalian Cell His
    Kit-1744 HDAC8 Fluorogenic Assay Kit N/A
    Kit-1961 HDAC8 Inhibitor Screening Assay Kit N/A
    Kit-2253 HDAC8 Activity Fluorometric Assay Kit N/A

    hdac8 involved in several pathways and played different roles in them. We selected most pathways hdac8 participated on our site, such as Alcoholism, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with hdac8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alcoholism HIST2H3A; SHC3; GM14476; H3F3B; HIST1H2BO; GNAI2; GNG8; HIST1H4I; HIST1H4H; GRIN3A
    Viral carcinogenesis KAT2A; REL; IKBKG; HLA-E; RBL1; GTF2H2; C3; HIST2H2BE; PIK3CA; PIK3CB

    hdac8 has several biochemical functions, for example, NAD-dependent histone deacetylase activity (H3-K14 specific), histone deacetylase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hdac8 itself. We selected most functions hdac8 had, and list some proteins which have the same functions with hdac8. You can find most of the proteins on our site.

    Function Related Protein
    NAD-dependent histone deacetylase activity (H3-K14 specific) HDAC1; HDAC7; HDAC8; HDAC2; HDAC5; HDAC6; HDAC4; HDAC9; HDAC11; HDAC9B
    histone deacetylase activity HDAC4; SIRT1; HDAC9; SIRT2; HDAC10; HDAC2; HDAC1; HDAC11; HDAC9B; HDAC8
    metal ion binding ITPA; GALNTL2; BMPR1A; NAIP7; MARCH9; STK32B; ZFP653; PRKCQ; AGFG1B; PKM
    transcription factor binding HDAC7; TAF7; IFT172; GATA6; PIANP; PPARG; PAX6; NCOR2; AIP; APBB3

    hdac8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hdac8 here. Most of them are supplied by our site. Hope this information will be useful for your research of hdac8.

    TP53; STAT3; bmf_human_gene; SEC16A; CPNE3; SVIL; TPM3; MME; NUP98; TPM4; SMC1A; CROCC; ZSCAN2; STAG2; MDM1; CHCHD3; ADD3; SMC3

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