HRAS

  • Official Full Name

    v-Ha-ras Harvey rat sarcoma viral oncogene homolog

  • Overview

    The 21 kDa guanine-nucleotide binding proteins (K-Ras, H-Ras and N-Ras) cycle between active (GTP-bound) and inactive (GDP-bound) forms. Receptor tyrosine kinases and G-protein-coupled receptors activate Ras, which then stimulates the Raf-MEK-MAPK pathway. GTPase-activating proteins (GAP) normally facilitate the inactivation of Ras. However, in 30% of human tumors, point mutations in Ras prevent the GAP-mediated inhibition of this pathway. The most common oncogenic Ras mutation found in tumors is Gly12 to Asp (G12D), which prevents Ras inactivation, possibly by increasing the overall rigidity of the protein.
  • Synonyms

    HRAS; v-Ha-ras Harvey rat sarcoma viral oncogene homolog; HRAS1; GTPase HRas; p21ras; H-Ras-1; p19 H-RasIDX protein; c-has/bas p21 protein; transforming protein p21; Ha-Ras1 proto-oncoprotein; c-ras-Ki-2 activated oncogene; GTP- and GDP-binding peptide B; transformation gene: oncogene HAMSV; Ras family small GTP binding protein H-Ras; CTLO; HAMSV; K-RAS; N-RAS; RASH1; C-H-RAS; H-RASIDX; C-BAS/HAS; C-HA-RAS1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Bacterial
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HRAS-383H Recombinant Human HRAS, GST-tagged E.coli GST
Human HRAS-701H Recombinant Human HRAS (Q61L) Protein E.coli N/A
Human HRAS-228H Recombinant Human HRAS(G12V), His-tagged E.coli His
Human HRAS-229H Recombinant Human HRAS(Mature form), His-tagged E.coli His
Human HRAS-2524H Recombinant Human HRAS protein(Met1-Cys186), His-tagged Insect Cells C-His
Human HRAS-5023H Recombinant Human HRAS Protein, GST-tagged Wheat Germ GST
Human HRAS-2135H Recombinant Human HRAS Protein E.coli
Human HRAS-13934H Recombinant Human HRAS, His-tagged E.coli His
Human HRAS-589H Recombinant Human HRAS, His-tagged E.coli His
Human HRAS-29177TH Recombinant Human HRAS E.coli N/A
Human HRAS-702H Recombinant Human HRAS (G12V) Protein, GST-tagged E.coli GST
Human HRAS-1025H Recombinant Human V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog, GST-tagged E.coli GST
Human HRAS-29173TH Recombinant Human HRAS, His-tagged E.coli His
Human HRAS-28759TH Recombinant Human HRAS E.coli N/A
Human HRAS-556HCL Recombinant Human HRAS cell lysate Insect Cell N/A
Human HRAS-3319H Recombinant Human HRAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HRAS-3848H Recombinant Human HRAS ΔC (S17N) Protein E. coli N/A
Human HRAS-5013H Recombinant Human HRAS Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human HRAS-3650HF Recombinant Full Length Human HRAS Protein, GST-tagged In Vitro Cell Free System GST
Human HRAS-1097H Recombinant Human HRAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human HRAS-1097H-B Recombinant Human HRAS Protein Pre-coupled Magnetic Beads HEK293
Human HRAS-244HFL Recombinant Full Length Human HRAS Protein, C-Flag-tagged Mammalian cells Flag
Human HRAS-1884H Recombinant Human HRAS Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human HRAS-0596H Recombinant Human HRAS Protein (M1-R169), GST tagged E.coli GST
Human HRAS-85H Active Recombinant Human HRAS Protein, His-tagged Bacterial His
Human HRAS-2737H Recombinant Human HRAS Protein (Phe82-Glu176), N-His tagged E.coli N-His
Mouse Hras-1169M Recombinant Mouse Hras Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat HRAS-2909R Recombinant Rat HRAS Protein Mammalian Cell His
Rat HRAS-2564R-B Recombinant Rat HRAS Protein Pre-coupled Magnetic Beads HEK293
Rat HRAS-1284R Recombinant Rat HRAS Protein (2-186 aa), His-tagged E.coli His
Rat HRAS-2564R Recombinant Rat HRAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HRAS-2141R Recombinant Rhesus monkey HRAS Protein, His-tagged Mammalian Cell His
Rhesus Macaque HRAS-1962R Recombinant Rhesus Macaque HRAS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque HRAS-1962R-B Recombinant Rhesus Macaque HRAS Protein Pre-coupled Magnetic Beads HEK293
Chicken HRAS-6844C Recombinant Chicken HRAS Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HRAS Related Articles
  • HRAS Related Research Area

HRAS involved in several pathways and played different roles in them. We selected most pathways HRAS participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with HRAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayRAF1;CACNA1B;AKT1;RASGRF2B;MAP2K4B;FGF13B;IL1R2;CACNA1G;PPM1A
ErbB signaling pathwayGAB1;MAPK8;CAMK2D1;PAK6;STAT5B;MAP2K4;CDKN1BA;PIK3R3B;MAPK8A
Ras signaling pathwayFGF6;RASAL2;GNG5;PDGFC;GNG12;PIK3CG;HTR7;RAB5B;VEGFC
Rap signaling pathwayFPR1;BRAF;ANGPT2;VEGFB;KITLG;RAC2;HGF;PDGFRB;FGFR1
Chemokine signaling pathwayCCL20;GNAI3;XCL1;STAT2;Ccl21c;GNB3;RAP1A;STAT3;PTK2B
FoxO signaling pathwayEGFRA;G6PC3;CCND2A;IGF1RB;RAF1B;TGFB2;FASLG;HRASB;GADD45BA
Sphingolipid signaling pathwayFCER1G;FYN;MAPK11;PLD2;MAPK8;PPP2R5B;MAPK10;PRKCB;MAP2K2
Phospholipase D signaling pathwayAGTR1B;RALB;PIK3R3;SHC3;PDGFRB;PPAP2A;KRAS;GNA12;FYN
EndocytosisEHD3;TFRC;SNX1A;RAB11FIP3;HSPA1A;SMAD2;FOLR2;MVB12BB;CHMP4B
PIK-Akt signaling pathwayPPP2CA;FASLG;GNG13;COL27A1;FGF10;FGF2;Itga10&Itgb1;PPP2R2B;GNG12
Axon guidancePPP3CC;COL9A1A;EFNA2;GFRA2;EFNA1B;CSNK2B;SEMA3D;KCNQ2;ITGB1
VEGF signaling pathwayMAPKAPK2A;PLA2G4C;AKT2;PPP3CCB;PTK2;PPP3CCA;RAC3B;NFATC2;CDC42L2
Focal adhesionMAPK8A;ACTG1;ITGA9;VEGFA;PAK7;PXNA;RAC3B;FYNA;COMP
Tight junctionMAGI1B;PRKCH;AKT2;CLDN1;RHOAD;MPDZ;CLDNB;ASH1L;MYH7
Gap junctionPRKCG;PRKACAB;PLCB3;LPAR1;GNA11A;MAPK7;TUBA8;GNAI2A;MAP2K2B
Signaling pathways regulating pluripotency of stem cellsMAPK11;POU5F1;JARID2;SETDB1;WNT3A;MAPK12;WNT7B;HRAS;APC
Jak-STAT signaling pathwayIL2RGA;HRASA;IFNA10;GM-CSF;AOX2P;PTPN11A;IL23R;TYK2;IL12A
Natural killer cell mediated cytotoxicityIFNA4;KIR2DL3;CD48;IFNG;HLA-B;ULBP2;FCGR3A;ITGB2;GZMB
T cell receptor signaling pathwayRAF1;PIK3R5;PLCG1;NFATC3;CD247;NRAS;CD8B;VAV2;MAP3K14
B cell receptor signaling pathwayDAPP1;RELA;PPP3R2;GSK3B;DOK1;BCL10;PIK3CA;ARPC1B;CTNNB2
Fc epsilon RI signaling pathwayPIK3R3;GAB2;MAP2K2;PLA2G4A;MAP2K1;MAPK11;TNF;SOS1;NRAS
Long-term potentiationGRIN2D;PRKACG;PPP1CB;GRIN1;GRM5;CAMK2G;CALML5;RPS6KA1;PLCB4
Neurotrophin signaling pathwayNGFRAP1;SHC1;RPS6KA3;RAC1;MATK;BDNF;MAPKAPK2;PIK3CG;CAMK4
Cholinergic synapseMAPK3;CAMK4;PLCB2;CHRM3;CHAT;CAMK2A;BCL2;AKT2;KCNJ12
Serotonergic synapseGNB4;HTR1F;ALOX12E;PLCB1;PTGS1;HTR5A;PRKCG;CYP4X1;ARAF
Long-term depressionPPP2R1A;PRKCA;HRAS;GUCY1A3;GNA13;GNAI2;PLCB3;PLA2G4C;IGF1R
Regulation of actin cytoskeletonItgam&Itgb2;FGF18;RRAS;ITGA6;ITGA6B;PIP4K2B;GSNB;RAC1;ITGAL
Insulin signaling pathwayCBLC;PDPK1B;INS;PPARGC1A;FBP1A;SHC2;RHOQ;HK3;HRASA
GnRH signaling pathwayGNA15.1;GNRHR1;PLCB4;MMP14;MMP2;CALM3;CALML5;GNRHR2;CAMK2G
Estrogen signaling pathwayCREB5;GRB2;RAF1;MAPK1;MMP2;CREB3L3;PRKCD;PIK3R3;SHC1
MelanogenesisCALM2A;FZD6;CAMK2A;MAP2K2B;DVL1B;TYRP1;PRKCBB;WNT7B;WNT16
Prolactin signaling pathwaySRC;TNFRSF11A;GSK3B;SOCS7;CSN2;IRF1;STAT1;PRL;HRAS
Thyroid hormone signaling pathwayPIK3CB;MED27;HIF1A;NOTCH1;RXRA;MAP2K2;GSK3B;RXRB;SLC16A2
Oxytocin signaling pathwayGUCY1A3;CACNG7;PPP1CC;ITPR3;MAP2K1;GUCY1B3;CAMKK2;EEF2K;PLA2G4D
AlcoholismHIST1H4M;CALM2;HIST1H4A;CALML5;HIST1H4G;NTRK2;HRAS;GNG5;GRIN2B
Hepatitis CPIK3CA;TYK2;EIF2AK1;PPP2R1B;LDLR;NFKB1;IFNA7;CLDN20;SCARB1
Hepatitis BHSPG2;BIRC5;FAS;MAP2K2;FOS;TLR2;IKBKE;TNF;APAF1
HTLV-I infectionTP53INP1;PDGFRA;MAP3K3;WNT9B;TGFB1;MYBL2;RB1;NFATC2;TSPO
Pathways in cancerVEGFC;RAD51;PTCH2;NOS2;TGFBR2;CCNA1;RHOA;WNT1;CDH1
Viral carcinogenesisATP6V0D2;NFKBIA;VDAC3;GTF2H2;YWHAG;HIST1H4N;BAD;HIST2H4A;PMAIP1
Proteoglycans in cancerCAMK2G;CCND1;SMO;Fasl;PIK3CA;IGF2;SDC4;CD44;THBS1
MicroRNAs in cancerKIF23;RHOA;EZR;PLCG1;ABCB1;PDGFRB;RAF1;GRB2;PTEN
Renal cell carcinomaVEGFA;SOS1;EPAS1;HRAS;ETS1;RAPGEF1;EGLN2;NRAS;HGF
Endometrial cancerCDH1;PIK3R5;PIK3CA;PIK3R1;CASP9;TP53;PIK3R3;FOXO3;MAP2K1
GliomaCALM3;PDGFB;PIK3R5;GRB2;SHC1;MTOR;KRAS;NRAS;PDGFRA
Prostate cancerMAP4K1;NDRG1;MAP2K1;PIK3R2;SMARCC2;MAPK1;NKX3;PDGFRA;CREB3L1
Thyroid cancerCDH1;TFG;LEF1;NRAS;HRAS;PPARG;MAPK3;KRAS;RET
MelanomaPIK3CB;BRAF;FGF19;HGF;FGF16;MAP2K2;PDGFRA;PIK3CD;AKT1
Bladder cancerBRAF;CDH1;ERBB2;UPK3A;MMP1;THBS1;IL-8;MMP1A;CXCL8
Chronic myeloid leukemiaTP53;RELA;AKT1;PIK3CD;TGFBR1;CBL;STAT5A;TGFB2;RUNX1
Acute myeloid leukemiaPML;NFKB1;SOS1;GRB2;CCNA1;KIT;HRAS;PIM1;JUP
Non-small cell lung cancerPIK3R3;TGFA;PRKCA;RARB;CCND1;STK4;RASSF1;ERBB2;TP53
Central carbon metabolism in cancerKRAS;NTRK3;FGFR2;MTOR;PIK3R2;PGAM1;RAF1;SCO2;G6PD
Choline metabolism in cancerPLD1;Pdgfa&Pdgfb;PIP5K1B;TSC2;PLA2G4B;DGKE;MAPK10;PIK3R5;SOS1

HRAS has several biochemical functions, for example, GTP binding, GTPase activity, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HRAS itself. We selected most functions HRAS had, and list some proteins which have the same functions with HRAS. You can find most of the proteins on our site.

Function Related Protein
GTP bindingRAP1B;RAB1BB;RASL10B;CDC42;EEFSEC;TUFM;RAB28;SCG5;RSG1
GTPase activityRAB8A;ATL3;RAB6A;GSPT2;MTG1;SRPR;MXB;RAB42A;RAB23
protein C-terminus bindingVGLL3;PEX1;MKI67;TBL1X;PDZD3;NPAT;TAX1BP3;DYNLL1;MAPRE1
protein bindingNFKB2;TBC1D24;ATP6AP2;CD200R4;GCH1;KLRD1;ZNF695;ANG;TACC3

HRAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HRAS here. Most of them are supplied by our site. Hope this information will be useful for your research of HRAS.

RAF1; SOS1

South, AP; Purdie, KJ; et al. NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:2630-2638(2014).
Fukumoto, S; et al. Anti-fibroblast growth factor 23 antibody therapy. CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION 23:346-351(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there targeted therapies specifically designed for HRAS-related cancers? 08/08/2022

Research is ongoing, but there are emerging targeted therapies designed to address HRAS-related cancers.

Can HRAS mutations be detected through genetic testing? 01/27/2019

Yes, genetic testing can identify HRAS mutations, aiding in the diagnosis and prognosis of certain disorders.

Can HRAS be a potential therapeutic target for non-cancerous diseases? 12/28/2018

Yes, there is growing interest in exploring HRAS as a therapeutic target for non-cancerous diseases, such as cardiovascular disorders.

How does HRAS influence the response to certain cancer treatments? 12/05/2018

HRAS status can impact the response to certain cancer treatments, affecting the efficacy of targeted therapies and chemotherapy.

How is HRAS involved in the regulation of the cell cycle? 03/18/2016

HRAS regulates the cell cycle by influencing the transition between different phases, ensuring proper cell division.

Customer Reviews (3)

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Reviews
08/15/2019

    With their meticulous documentation and support, I am confident that my utilization of the HRAS protein in clinical trials will meet all necessary regulations and guidelines.

    06/26/2019

      Their comprehensive certificates of analysis and safety data sheets serve as testaments to their commitment to ensuring the safety and integrity of their products.

      09/12/2018

        Their ability to accommodate the requirements of large-scale experiments and guarantee a steady supply streamlines my research operations, eliminating any concerns related to prospective shortages.

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